A randomized, prospective study of the effectiveness of preoperative administration of coenzyme Q10 on the prophylaxis of postoperative low cardiac output state was performed in 50 patients with acquired valvular diseases necessitating valve replacement. There were 25 patients in the treatment group and 25 in the control group. Patients in the treatment group received 30 to 60 mg of coenzyme Q10 orally for six days before operation. Preoperative clinical variables, operative procedures, total cardiopulmonary bypass time, and aortic cross-clamping time were similar for the two groups. Postoperatively, mild to severe low cardiac output state developed in 28 of 50 patients (56%) and necessitated the administration of considerable amounts of inotropic agent. The treatment group showed a significantly lower incidence of low cardiac output state during the recovery period than the control group (p less than 0.05). These results suggest that preoperative administration of coenzyme Q10 will increase the tolerance of human hearts to ischemia during aortic cross-clamping.

Adult↗

PubMed1982

Blood coagulation study after open-heart surgery without blood transfusion.

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Adolescent↗

PubMed1982

[Clinical evaluation of pulsatile flow by pulsatile bypass pump for deep hypothermia and circulatory arrest in infants].

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Animals↗

PubMed1977

Ventricular septal defect: selection of patients and timing for surgery.

Eighty-seven patients with isolated ventricular septal defect (VSD) operated on in the first 5 years of life, that had a mean interval of 10 months between diagnostic catheterization and surgery, were studied retrospectively. The size of the VSD was correlated with diagnostic catheterization data and comparative analysis of clinicl findings (ECG and CTR) was made between the time of diagnostic catheterization and just prior to surgery. The study showed that 42 per cent of patients with the ratio of systolic pulmonary artery pressure to systolic systemic artery pressure (Pp/Ps) 0.5 to 0.8 had a marked reduction in size of VSD in a rather short interval of 10 months. In patients with Pp/Ps greater than or equal to 0.8, the incidence of decrease in VSD size was close to nil. The highest incidence of decrease in VSD size was seen in patients with high flow and low resistance. ECG and CTR were very useful diagnostic tools to follow the course of the VSD size. The patients with Pp/Ps 0.5 to 0.8 should be observed for an interval of 10 to 12 months, expecting spontaneous decrease in VSD size. If clinical parameters (ECG, CTR) fail to improve in that interval, then the patients should have surgery. The patients with Pp/Ps greater than or equal to 0.8 should be operated on without delay.

Blood Pressure↗

PubMedDate not supplied

Appearance and disappearance of empty delta sign in superior sagittal sinus thrombosis.

The diagnostic value of the empty delta sign on post-infusion CT films was investigated in five patients with superior sagittal sinus thrombosis subsequently verified angiographically and/or pathologically. The empty delta sign, which has been considered to be unique and reliable in the diagnosis of cerebral venous sinus occlusion, was observed only on CT films taken one to four weeks after onset, and was not seen in the extremes of the acute or the chronic stage of the illness. These observations may explain why this sign has not been apparent in some reports concerning the CT findings of superior sagittal sinus thrombosis. Recanalization within the thrombus may be the reason why this sign was no longer apparent in the chronic stage of the patients with superior sagittal sinus thrombosis.

Adult↗

PubMedDate not supplied

Surgical treatment of respiratory insufficiency due to tracheobronchial compression by aneurysms of the ascending aorta and innominate artery.

Two patients with life-threatening respiratory insufficiency resulting from tracheobronchial compression by expanding aneurysms of the ascending aorta and innominate artery were successfully treated by cardiopulmonary bypass, even in the presence of significant aortic regurgitation. The pertinent surgical procedures are described.

Aged↗