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Biomedical subjects

M Z Blumberg

Publications and source records attributed to M Z Blumberg.

10 recordsLinked to original sources

Terbutaline and ephedrine in asthmatic children.

The effects of terbutaline, ephedrine, and placebo on the cardiovascular and pulmonary systems have been compared in 24 asthmatic children. Ephedrine and terbutaline were both found to be effective bronchodilators, with onset of action within 30 minutes. The bronchodilator effect of ephedrine was maintained for three hours, while terbutaline was active for five hours. Terbutaline caused significantly greater improvement in pulmonary functions than did ephedrine. Both terbutaline and ephedrine were associated with clinically insignificant changes in blood pressure and pulse rate. The only significant side effect observed was hand tremor in children receiving terbutaline and this appeared only early in the course of drug treatment. There was no evidence of tolerance to the bronchodilator effect of ephedrine or terbutaline after eight weeks of therapy.

Adolescent↗

The total eosinophil count in asthmatic children.

The diurnal variation in total eosinophil count (TEC) in asthmatic children not on medications or on thophylline-containing bronchodilators orally every 6 hr is similar to that reported in normal subjects, with a decrease in TEC in the morning and an increase in the evening. Asthmatic children taking prednisone in 8:00 A.M. on alternate days have diurnal variations in TEC on the "day off" prednisone similar to those on normal children. On the "day on" prednisone, administered either on a daily or alternate-day basis, TECs approach zero 4 to 8 hr after prednisone is taken. The TEC then increases in the evening as it does in children not taking prednisone.

Adolescent↗

The total eosinophil count and adrenal function in asthmatic children.

In 36 asthmatic children 8:00 a.m. plasma cortisol levels were compared with changes in their total eosinophil count (TEC) from 8:00 a.m. to 9:30 a.m. All children with low cortisol levels had decreases in TEC of less than 2%, whereas 78% of children with normal cortisol levels had decreases greater than 15%. All children with decreases greater than 15% had normal cortisol levels.

Adolescent↗