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Biomedical subjects

M Z Mocan

Publications and source records attributed to M Z Mocan.

13 recordsLinked to original sources
PubMed2001

Thyroid function tests in pregnant women with and without goiter in the eastern Black Sea region.

Maternal thyroid function was investigated in 29 pregnant women with goiter and 51 pregnant women without goiter in the eastern Black Sea region of Turkey, which is an endemic goiter area. Ten women with goiter and 10 healthy women without goiter were used as controls in the study. In all of the pregnant women, increased concentrations of total and free thyroxine, total and free tri-iodothyronine and thyroxine-binding globulin were found. Serum thyroid-stimulating hormone levels showed a decrease in pregnant women without goiter compared with non-pregnant women without goiter.

Adult↗
PubMed1998

Urinary cAMP activity in chronic renal failure.

Forty-six patients with chronic renal failure and 17 healthy controls were examined to determine their urinary cyclic adenosine monophosphate (UcAMP) levels. In the study group, UcAMP levels were found to average 1542 picomoles; in the controls, 4612 pmoles (P<0.001). UcAMP activity decreased in tandem with the decline of the glomerular filtration rate. Hypertension was not found to have an additional effect on UcAMP levels, and there was no statistical difference in UcAMP levels between the normotensive and hypertensive patients (P>0.05).

Adult↗
PubMed1998

Postpartum hemolytic uremic syndrome with a more severe liver involvement.

A 22-year-old woman presented with postpartum hemolytic uremic syndrome with a more severe hepatic involvement. The patient was dialysed and successfully treated with plasma infusion and intravenous immunoglobulin. Two months following discharge her creatinine clearance was 105 ml/min/1.73 m2, 99mTc DTPA scan and brain CT were normal. Here child is also alive and healthy.

Adult↗
PubMed1997

Pyknodysostosis: hemangioma of the skull as a new finding.

Pyknodysostosis is a rare sclerosing bone dysplasia syndrome with autosomal recessive inheritance. Here, we report a case of pyknodysostosis, with characteristic physical and radiological findings, but also with a hemangioma of the skull, as a non reported finding sofar.

Adult↗
PubMed1995

Effect of essential amino acid supplementation in acute renal failure.

The effect of intravenous (i.v.) essential amino acids (EAA) in the treatment of acute renal failure was evaluated in 50 patients. Thirty patients (Group A) received daily 13.4 g of i.v. EAA solution [Nephramine (Don Baxter, McGraw) 250 ml/d]+dopamine i.v. 2 micrograms/kg/min + 20% hypertonic glucose solution 500 ml/d as compared with twenty patients (Group B) who received dopamine i.v. 2 micrograms/kg/min + 20% hypertonic glucose solution 500 ml/d. In Group A patients showed lower daily increase in blood urea nitrogen (BUN) (p < 0.05), higher serum total protein and albumin levels on the 15th day of the posttherapy period (p < 0.001), lower complication rate (p < 0.005), lower mortality rate (p < 0.005) and a reverse relation between serum total protein concentration, duration of oliguria and age (p < 0.01, r2 = 0.26; p < 0.001, r2 = 0.32). These data suggest that treatment of such patients with i.v. EAA solutions significantly improves survival.

Acute Kidney Injury↗
PubMed1992

Histological and electron microprobe studies of mineralisation in aluminium-related osteomalacia.

AIMS: To determine a possible mechanism to explain the presence of aluminium lines within fully calcified bone in aluminium-related osteomalacia. METHODS: Fifty five bone cases shown by bone biopsy to be aluminium-related osteomalacia were studied. In 38 specimens aluminium lines were identified within calcified bone by means of the Aluminon stain and a characteristic form of patchy mineralisation was seen within thickened osteoid seams. Five representative examples were analysed quantitatively by histomorphometry and electronprobe X-ray microanalysis and compared with five cases of vitamin D deficiency-related osteomalacia which also had patchy mineralisation. RESULTS: The patchy calcification occupied 40 +/- 8% (mean +/- SEM) of the osteoid and consisted of small focal deposits (less than 40 microns diameter), often (52%) around osteoid osteocytes (probably an underestimate of the association), and larger areas that extended to the aluminium lines at the underlying mineralisation front. Small and large mineralisation nuclei were seen ultrastructurally in the patchy calcification. Quantitative electronprobe X-ray microanalysis showed that calcium concentrations and calcium:phosphorus ratios in the mineralisation nuclei and in the superficial layer of the fully calcified bone of the aluminium-related osteomalacia cases were significantly less than values measured at similar sites in the vitamin D deficiency-related osteomalacia cases. Furthermore, aluminium could not be detected by means of this technique at the mineralisation front or along cement lines in these specimens. CONCLUSIONS: Calcification can occur in thickened osteoid seams in osteomalacia. It can begin around osteoid osteocytes as small deposits that enlarge within the osteoid and extend to the underlying mineralisation front or cement line where aluminium lines may become trapped. Complete calcification of osteoid could account for the presence of aluminium lines within fully calcified bone. The Aluminon stain appears to be a more sensitive method for the detection of aluminium in bone than electronprobe X-ray microanalysis.

Adult↗
PubMed1992

Autonomous hyperparathyroidism not associated with increased aluminum absorption.

A single 6-g dose of aluminum hydroxide was given to eight patients on regular hemodialysis before and 3 days after parathyroidectomy (PTX). Serum aluminum levels were measured before and after 5 h after ingestion of aluminum hydroxide to examine indirectly the effects on absorption of aluminum from the gastrointestinal tract of both high and low parathyroid hormone (PTH). Plasma PTH levels fell significantly from 2,724 +/- 1,830 ng/l (mean +/- 1 SD) before PTX to 352 +/- 63 ng/l after PTX. However, no significant change was detected in serum aluminum levels before or after PTX (1.45 +/- 0.96 to 1.92 +/- 0.88 mumol/l before PTX; 2.02 +/- 1.41 to 2.89 +/- 1.19 mol/l after). These findings indicate that in patients with chronic renal failure, high plasma levels of PTH are not associated with significant increases in serum aluminum concentrations after ingestion of a large quantity of aluminum hydroxide. Parathyroid hormone may not enhance intestinal absorption of aluminum in humans.

Adult↗
PubMed1990

Changing incidence of anencephaly in the eastern Black Sea region of Turkey and Chernobyl.

The incidence of neural tube defects (NTD) was 2.12 per 1000 births and that of anencephaly was 1.29 per 1000 births when we reviewed the 40,997 consecutive births between 1981 and 1986 in the major maternity hospital in the eastern Black Sea region of Turkey. There was a significant increase in the incidences of NTD and anencephaly after 1986 to 4.39 and 2.46 per 1000 births respectively (P less than 0.0001; P less than 0.005). Although this might be a coincidence, it may be due to the nuclear contamination of the region following the Chernobyl accident.

Accidents↗