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Biomedical subjects

M Zabek

Publications and source records attributed to M Zabek.

33 records · Page 2Linked to original sources
PubMed1995

Neurofibromatosis type 2. Case report.

A case of a 24-year-old woman with peripheral paresis of the facial nerve, balance disturbance, hearing loss and epileptic seizures for many years is presented. At time of admission to hospital cerebral magnetic resonance imaging (MRI) showed several large tumors situated supra- and infratentorially. Histological examination of the operated tumors revealed bilateral acoustic schwannomas in the cerebellopontine angles and mixed meningioma in the others. The patient was diagnosed as neurofibromatosis type 2 (NF2) according to clinical criteria for neurofibromatoses. Several months after the last operation, she exhibited weakness of all extremities. On spinal MRI an intramedullary tumor in the cervical region and additional focal lesions along central canal were found. Surgical therapy was not performed because of clinical improvement after dexamethasone treatment and location of lesion in cervical medulla. Our case confirms frequently occurring lack of neurocutaneous changes and late appearance of significant neurological symptoms in NF2.

Adult↗
PubMed1992

Cerebral ganglioglioma with long history and unusual prominence of the mesenchymal elements. Case report.

A case of cerebral ganglioglioma, a relatively rare and controversial tumor of the central nervous system, is reported. The histological pattern of the tumor consisted of differentiated neuronal cells and glial elements displaying a various extent of cytologic abnormalities. Beside these two typical components for ganglioglioma, an abundance of collagen fibrils and numerous blood vessels were encountered. The long clinical course manifested by temporal epilepsy preceding clinical diagnosis of brain tumor and peculiar histological appearance seem to be of considerable interest.

Brain Neoplasms↗
PubMed1992

[Transplantation of fetal dopaminergic cells in Parkinson disease].

Four patients with severe form of Parkinson's disease received transplantation of fetal dopaminergic cells into the caput of the caudate nucleus. The operation was done by an original method using a device designed specially for this purpose. In all cases the duration of the disease was 10 to 15 years, and the predominating signs were tremor, bradykinesia, and markedly pronounced side effects of the treatment (on-off syndrome and involuntary movements). One patients died 5 weeks after the operation. Autopsy demonstrated good survival of the transplanted cells with good integration with the brain of the recipient and traces of positive immunocytochemical reaction for tyrosine hydroxylase. In the other patients a significant clinical improvement was noted after the operation, with reduced intensity of parkinsonian symptomatology, shortening of the duration of the off phase, improved motor ability and reduced intensity of the involuntary movements. The longest follow-up was 24 months.

Brain Tissue Transplantation↗
PubMed1992

[Extensive bifocal location of ependymoma of the spinal cord].

Spinal cord ependymomas belong to rare tumours of the central nervous system. Their malignancy is usually low although anaplastic forms are known also to occur. Surgical treatment is the method of choice supplemented often with radiotherapy. An exceptionally rare form of ependymoma with two foci of origin in the spinal cord is reported. The large extent of the tumour caused that laminectomy at 15 levels was necessary. The mechanism of ependymoma development at two levels is discussed.

Adult↗
PubMed1992

[Anatomy of the middle cerebral artery and the angiographic image of its aneurysms].

The study is based on conclusions drawn from the microanatomical analysis of 200 middle cerebral arteries and angiographic findings in 40 aneurysms of the artery. The angiograms were analysed considering the site of the aneurysm with respect to the division of the artery at the limen insulae and presence of early temporal arteries. Correlating these data with the anatomical observations, especially with regard to the site of origin of the perforating arteries it was tried to define more strictly the facts relevant to the operation which can be obtained by angiography.

Brain↗
PubMedDate not supplied

Meningioma with the unique coexistence of secretory and lipomatous components: a case report with immunohistochemical and ultrastructural study.

Meningiomas exhibit a broad spectrum of differentiation potency corresponding to different histological subtypes. The separate secretory or lipomatous transformation of meningothelial cells is uncommonly encountered in meningiomas classified into distinct secretory or lipomatous variants. The coexistence of these two different histological subtypes is extremely rare. We report an exceptional case of secretory meningioma associated with extensive lipomatous component in a 58-year-old woman. CT scan and MRI of the brain showed a well-defined tumor mass in the right temporal lobe with areas of adipose tissue and extensive surrounding brain edema. Microscopically, the tumor was composed of two components: whorls of meningothelial cells with numerous PAS-positive hyaline inclusions (pseudopsammoma bodies) and numerous mature adipocyte-like cells. The presence of neutral fat was confirmed by oil-red-O staining. The hyaline inclusions and tumor cells surrounding them showed strong immunoreactivity for EMA and CEA. Ultrastructural findings confirmed both secretory and lipomatous differentiation of tumor cells. The majority of lipidized neoplastic cells shared the features of meningothelial cells and adipocytes. Our result supports the opinion that lipomatous component ought to be considered as an advanced lipidization of neoplastic meningothelial cells rather than true metaplastic transformation of meningothelial cells into mature fat tissue. The present case of meningioma demonstrates a unique coexistence of secretory and lipomatous meningothelial components, reflecting the multipotency of phenotypic transformation of primary meningothelial cells.

Female↗
PubMedDate not supplied

[Neurotransplantation. III. Intracerebral grafting of fetal substantia nigra in Parkinson's disease].

The paper reports the results of fetal substantia nigra transplantations into the brain of patients suffering from Parkinson's disease, performed in different neurosurgical centers in the world. Commonly accepted Ethical Guidelines for Fetal Tissue Transplantations are presented. The criteria regarding patients selection for therapeutic transplantation are also discussed. The results of studies concerning the problem of optimal fetal age for transplantations are presented. The optimal age seems to cover the period between the 7th gestational week when dopamine synthesis begins and the 11th week when protoplasmic processes start to grow intensively. The damage of these processes during transplantation procedure is thought to make the fetal cells survival difficult. The discussion concerning controversial problem of immunosuppression treatment after the neurotransplantation is also reported. The paper presents the principles of signs and symptoms assessment before and after operation including CAPIT system which emphasises the role of movement ability tests, PET-scanning with [18F]-6-L-fluorodopa and magnetic resonance imaging. The PET-scanning allows to follow up the changes in patient's brain resulting from the graft survival and its dopamine synthesis ability. The methods of donor woman examination to avoid the transmission of infections into the patient's brain are reviewed. The analysis of yet published results of about 100 operated on parkinsonian patients show marked improvement due to human fetal substantia nigra transplantation. The improvement lasts, at least 46 months postoperatively (the longest period of observation). Many of the grafted patients returned to normal self-dependent living activities and some of them resumed even their professional jobs. Most authors present the opinion that the therapeutic effects of fetal substantia nigra transplantations are more valuable and longer lasting than those after adrenal medulla autografts. However it should be borne in mind that both methods are yet only the experimental approach in Parkinson's disease therapy.

Fetal Tissue Transplantation↗
PubMedDate not supplied

[Contribution to the microanatomy of the proximal part of the arteria centralis longa (Heubner's artery)].

The anterior communicating artery complex is one of the most frequent intracranial aneurysm sites. Pterional craniotomy is the usual way to expose this region. While exposing of the aneurysmal dome, the posterior part of the gyrus rectus is frequently resected. In this stage of the procedure and later during clipping of the aneurysm, the surgeon's manipulation is closely related to the proximal part of the Heubner's artery. This vessel feeds important structures in the region of the basal ganglia. The anatomy of the Heubner's artery was described by many authors. However the intraoperative identification of this artery is still not clear. Therefore we performed detailed microanatomical investigation of the proximal part of the Heubner's artery in 40 brain hemispheres. It was found that during resection of the posterior part of the gyrus rectus two arteries are exposed. The recurrent Heubner's artery runs posteriorly to the gyrus rectus. The second artery runs on the medial and inferior surface of gyrus rectus supplying cerebral cortex. This artery frequently originates from the A1/A2 junction or the proximal part of the A2 segment of the anterior cerebral artery. Because of it, this cortical artery is difficult to distinguish from the recurrent Heubner's artery. This artery can branch out from the recurrent Heubner's artery or the frontopolar artery. In conclusion, the greatest probability of the injury to the recurrent Heubner's artery may occur during resection of the posterior part of the gyrus rectus.

Adult↗