PubMed Health⌕ Search

Biomedical subjects

M Zambelli

Publications and source records attributed to M Zambelli.

25 records · Page 2Linked to original sources
PubMed1990

Centred radio-frequency hyperthermia in solid tumours.

After some notions on the mechanisms of action of radio-waves on solid tumours, the treatise illustrates the results achieved in the first 125 cases of malignant tumours treated with this method, its results are definitely encouraging, even in cases apparently with no hope. It also describes briefly the histologic modifications induced by this therapeutic method on neoplastic masses and discusses the criteria of the directions of thermotherapy, alone or combined, which is obviously the fifth weapon against tumours.

Adult↗
PubMed1989

[Free forearm flap in the reconstruction of mucosal defects of the oral cavity and oropharynx after radical removal of a tumor].

In the Department of Surgery, Clinical Hospital Center Rijeka in cooperation with ENT Department and the Department of Maxillofacial Surgery, fifty patients with the mouth and the throat tumor were operated since 1985. The defects were covered with free radial forearm flaps. In seven cases flap did not survived due to thrombosis of the anastomosis. The arterial anastomosis were usually made on the external carotid artery branches. Seven anastomosis were made on the opposite side of the neck because homolateral carotid artery was ligated. In three cases terminolateral anastomosis with common carotid artery was made. In eight patients the bone defect of the lower jaw was reconstructed with vascularized radial bone graft. Irradiation and/or cytostatic therapy was mostly applied two weeks after surgery. The donor site defect has no functional nor aesthetic implications.

Forearm↗
PubMedDate not supplied

The radial forearm free flap: our experience in solving donor site problems.

Special attention is paid to the problems of the donor site (the forearm) in a series of 75 patients who underwent orofacial malignancy excision. An island skin flap from the ulnar aspect of the forearm, used in 15 patients, is reported to be an improvement of the surgical technique. No healing complications were observed, and the aesthetic and functional results were very good.

Bone Transplantation↗
PubMedDate not supplied

Considerations on pulsoplethysmographic changes in fingers due to iontophoresis with methacholine in subjects with Raynaud's phenomenon.

This paper presents a study of plethysmographic changes induced by methacholine (a derivative of acetylcholine) administered via iontophoresis in a population of 41 young women with apparently primary Raynaud's disease. All patients presented with a very clear statistically significant sphygmic increment, obviously connected with the vasodilatation caused by methacholine. Moreover, in nearly half of the 23 cases whose reaction to passive postural variations was successively examined by plethysmography, the district circulatory response was characterised by persistent neurogenous vasoconstriction due to methacholine or by inadequate vasomotor EDRF mediated modulation. The authors believe that their findings serve as further evidence of the pathogenetic mechanisms of Raynaud's disease. This is because they highlight the role played by "balance of vessel motility" which would guarantee district circulatory homeostasis. Concrete proof thus corroborates well known indirect evidence that a pathological vasospasm can be triggered and persist when two fundamental conditions are met: a) intense vasoconstriction initially of neurological origin and successively reinforced by biohumoural synergic stimuli; b) the breakdown of the capacity for EDRF mediated intrinsic vasomotor modulation. It is suggested that the prevalence of one or the other factor would lead to a variety of clinical pictures denoting vascular acrosyndromes of this type. The ability to single out such clinical pictures by adding the iontophoresis test with methacholine to routine screening procedures for the presence of Raynaud's disease, would allow physicians to make more accurate diagnosis and improve therapy.

Adult↗
PubMedDate not supplied

[Occupational exposure to vibration: Raynaud's phenomenon and the vascular response to methacholine iontophoresis].

A homogeneous group of 34 subjects exposed to occupational vibratory stress were studied to determine their vasodilatory response to methacoline. The methacoline was administered by iontophoresis. Methacoline is an acetylcholine derivate with the same pharmacological properties of acetylcholine. The 34 study subjects were divided into 3 groups according to their plethysmographic response to a preliminary cold test: group 1, had a typical Raynaud's response; group 2 had normal response to cold, and group 3 had an "intermediate" response. The subjects in group 1 did not respond to methacoline with vasodilation, suggesting endothelial damage at the arterial and arteriolar level, those in group 2 responded with clear vasodilation, and those in group 3 had an intermediate plethysmographic response to methacoline--modest, slowed vasodilation. Based on the results obtained, the authors believe that the true pathogenetic mechanism is an alteration in the vasomotor stability. This change in circulatory homeostasis occur after a vasoconstrictive stimulus, due to vascular endothelium disfunction, in its turn damaged by vibratory microtrauma. This would be the basis for diminished autonomic vascular regulation, mediated by EDRF at the arterial and arteriolar level. It is also probable that the pathogenesis of Raynaud's syndrome in workers exposed to physical or chemical stress has a similar mechanism.

Aged↗