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Biomedical subjects

M Zannoni

Publications and source records attributed to M Zannoni.

At least 37 records · Page 2Linked to original sources
PubMed1989

Effects of long-term nicardipine treatment on hemodynamics of large arteries in essential hypertension.

The effects of the calcium-entry blocker nicardipine on brachial hemodynamics were studied in 22 patients (18 male, 4 female) with essential hypertension, who were treated with 20 mg tid for 1 year. Compliance, characteristic impedance, vascular resistances, and tangential tension were measured before treatment and after 1, 3, and 12 months of treatment by an automatic recording from a B-mode, high-resolution, real-time scanner and pulsed Doppler velocimetry for the calculation of the flow volume. We observed statistically significant variations in compliance and impedance after 1 month (3.21 +/- 0.59 dyn-1 cm4 10(-7) vs. 1.26 +/- 0.16 dyn-1 cm4 10(-7) and 50.6 +/- 4.7 dyn s cm-510(2) vs. 91.4 +/- 7.3 dyn s cm-5 10(2), respectively; mean +/- SEM; p less than 0.001), while tangential tension was significantly reduced after only 3 months (23.2 +/- 2.2 mmHg vs. 25.4 +/- 2.3 mmHg cm; p less than 0.05). The correlation between variations in mean blood pressure and in the hemodynamic parameters studied remained statistically significant throughout the study. Nicardipine improved the parameters of large-artery hemodynamics that favor a normal systolic pulse.

Adult↗
PubMed1989

Comparative efficacy of ketanserin and pentoxiphylline in treatment of Raynaud's phenomenon.

In a randomized, placebo-controlled, crossover study, 15 ambulatory patients with Raynaud's phenomenon, treated for three weeks with ketanserin 80 mg/day and pentoxiphylline 1,200 mg/day, were evaluated by subjective symptom scores, daily frequency and duration of attacks, and photoplethysmography, at room temperature and after cold test. Reduced subjective symptoms and duration of attacks, together with improved cold test plethysmography, were significant only after ketanserin. All subjective symptom scores also improved after ketanserin but only for cyanosis and paresthesia after pentoxiphylline. Excellent results were obtained in 4 cases after ketanserin and in 1 case with pentoxiphylline. The authors discuss the greater importance of antivasospastic action over antiaggregating and hemorheologic effects in Raynaud's phenomenon therapy, as well as the pathogenetic role of serotonin.

Adult↗
PubMed1989

Defibrotide and peripheral obliterative arterial disease: preliminary data.

In a pilot study, defibrotide was administered to 22 patients with arterial occlusive disease of the lower limbs (mean age 59 years; range 48-71 years), of whom 12 were Fontaine 2nd stage and 10 Fontaine 3rd stage. In the first group, treatment enabled significant improvement in the walking distance (580 +/- 95 vs 220 +/- 65 m; M +/- SD; p less than 0.001), even 15 days after discontinuation of therapy (445 +/- 110 m; p less than 0.05). In 3rd stage patients, treatment caused reasonable reduction of pain, with elimination of resting pain in 4 patients. Both groups underwent no modification of Doppler velocimetry and Winsor index, while photoplethysmography in 8 patients at 2nd- and in 3 patients at 3rd-stage showed improvement at the end of treatment. There were no modifications of hepatic, renal, hemopoietic and hemocoagulative functions. Beta-thromboglobulin showed a statistically significant reduction (62 +/- 10 vs 116 +/- 18 ng/ml; M +/- SEM; p less than 0.001), from 2 weeks after the first dose until 15 days after discontinuation of therapy. Defibrotide proved particularly efficacious in Fontaine 2nd-stage patients, showing its suitability for treating the stages of occlusive atherosclerotic disease at which collateral circulation can still be activated.

Aged↗
PubMed1982

[Changes in the principal biohumoral parameters after jejuno-ileal bypass in rats with experimentally induced obesity (preliminary note)].

End-to-end jejuno-ileal by-pass is one of the most extensively used surgical procedure in the treatment of morbid obesity. The Authors evaluated hematologic indices in experimentally induced obese Sprague-Dowley rats and their modifications after jejuno-ileal by-pass. This surgical procedure induced a significant weight loss and a considerable improvement of glucidic and lipidic metabolic disorders, presents in experimentally obese rats. The Authors conclude that an intestinal by-pass preserving a jejuno-ileal tract with sufficient absorbtion potential, is able to induce adequate weight loss with regression of glucidic and lipidic metabolic disorders, in absence of heavy alterations of the others hematologic indices.

Animals↗
PubMed1981

[Influence of lymphostasis on healing processes of intestinal anastomoses. Experimental research].

The Authors studied the healing of the intestinal anastomoses in rats with mesenteric and celiac lymph-vessels coagulated and cut. The experiment was realized utilizing 104 rats, divided in fours groups: after the induction of the lymphostasis, in the first group an end-to-end ileal anastomosis was made by polyglycolic acid suture, 6/0 in diameter. The control groups consisted of rats with ileal anastomoses, with lymphostasis solely and sham operated. The macroscopic observation and the histological findings were studied 7 and 14 days after the anastomoses' performance. Only in the animals with lymphostasis was observed an anastomosal leakage of 19% at 7th day control. In the same period the histologic sections showed a modified anastomosal healing, related to the significant reduction of the granulomatous tissue formation in presence of the lymphostasis.

Animals↗
PubMed1981

[Preservation of the pectoral nerves in modified radical mastectomy].

Modified radical mastectomy with preservation of one or both pectoral muscles is the surgical treatment of choice in stage I and II breast cancer. A surgical anatomic study has been performed, based on post-mortem and intraoperative findings, to investigate origin and course of lateral and medial pectoral nerves and their relations to pectoral muscles and axillary lymphonodes. The results suggest that Patey-Meier operation can produce, in 80 per cent of cases, atrophy and fibrosis of the costoabdominal portion of the pectoralis major muscle as lateral pectoral nerve is generally dissected. On the contrary, radical mastectomy with both pectoral muscles preservation permit also to preserve the nerves during lymphadenectomy if they are recognized.

Atrophy↗