Biomedical subjects
Publications and source records attributed to M Zlateva.
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The authors carried out experiments on animals (40 white male rats) which were subjected to daily a two-hour action of the common vertical sinusoidal vibrations with a frequency of 20 Hr (I group) and 50 Hr (II group) with acceleration of 22,0 m/sec2 for a period of ten days (I group--A and second group--A) and 30 days (I group--B and II group--B). Histomorphological and histochemical methods were used and the authors found changes in microcirculation and structure of the intestinal wall manifested in the animals of the II group. The obtained results were in support of the clinical data on the disturbances in intestinal function in patients with vibration disease and corresponded to the experimental data on the occurrence of vascular and dystrophic changes in the internal organs under vibration action.
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The chronic action of the preparation vofatox 50 causes changes in the spermatopoeitic epithelium of white rats, which depend on the doses and duration of intoxication. There is an increased vascular permeability and degenerative changes in the spermatogenic epithelium, a reduction of the mitotic process and also index of spermatogenesis at the initial stages. The later changes are manifested by more formed changes in the spermatopoietic cells, appearance of gigantic multicellular forms, lack of sprematozoa in a large number of canaliclues and fibrosis of blood vessels. The changes in the testis are the result of the general toxic action of the preparation.
Histological investigations were carried out upon the state of the gastric and duodena mucosa in 27 young patients with duodenal ulcer, seven out of them being in the state of exaverbation of the ulcer and 20-in remission. While the duodenal mucosa in the majority of the cases (88.9%) was established to be affected, in 85.2 percent of the patients the gastric mucosa remained intact. The chronic duodenitis observe n 24 of the cases have no atrophic character. The changes in the mucous secretion of duodenal mucosa are in direct correlation with the state of exacerbation or remission of the ulcer process. Similar correlation was not established in gastric mucosa.
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Biochemical and histochemical studies are undertaken with the purpose to establish the state of the aortic wall groung substance in white rats, poisoned over a 10-day period with lead acetate (1/100 LD50) and manganese bichloride (1/100 LD50), separately and in combination. It is demonstrated that either of the metals, both separately and in combination, lead to an increase of the quantity of acid, and to a decrease of the quantity of neutral mucopolysaccharides. It is worth noting that upon combined action, a relative augmentation takes place also of hyaluronic acid in all the layers of the aortic wall. The changes observed point to quantitative and qualitative alterations in the intercellular substances of the aortic wall leading, in turn, to disturbances in its permeability.
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