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Biomedical subjects

M Zuber

Publications and source records attributed to M Zuber.

225 records · Page 13Linked to original sources
PubMedDate not supplied

[Proliferative myositis with compression of the sciatic nerve].

A case of proliferative myositis, an unusual inflammatory pseudotumour of skeletal muscle, is reported. This case was particular in that the lesion was located in the popliteal fossa, developed over a long period and above all, was revealed by compression of the sciatic nerve. The diagnosis was confirmed by peripheral biopsy of the mass which showed normal muscular tissue associated with numerous fibroblasts and with characteristic basophilic giant cells. The clinical, histological and pathogenetic features of the disease are discussed with emphasis on the importance of a thorough pathological examination to exclude with certainty a possible sarcoma.

Aged↗
PubMedDate not supplied

[In vitro availability of a topical corticosteroid from various vehicles. Attempt at a correlation with an in vivo study].

The object of the study is to show the availability of a topical corticosteroïd (difluprednate) from pharmaceutical forms: the gel and cream forms in which the substance is solubilised, the greasy and emulsified forms in which the substance is dispersed. The bioavailability of these forms dosed to 0.025% was evaluated by a cutaneous vasoconstriction test. The results show that the cutaneous penetration of difluprednate is more favourable in the gel and cream forms. The "in vitro" availability of commercial dosage forms (0.05% of difluprednate) and the "in vivo" results are compared and commented.

Biological Availability↗
PubMedDate not supplied

[Antinuclear antibodies in rheumatology].

Antinuclear antibodies are autoantibodies which are hallmarks of connective tissue diseases. They are directed against intracellular antigens. As a first step of the diagnostic procedure, screening for antinuclear antibodies is performed on HEp-2 cells as a substrate. Different immunofluorescence patterns such as homogeneous, rim-like or speckled can be seen and the antibody titer is determined. In a second step of the diagnostic procedure the antinuclear antibodies are differentiated into defined species. Systemic lupus erythematosus, Sjögren's syndrome, mixed connective tissue disease, polymyositis and dermatomyositis are characterized by disease-specific antibody profiles, which can be measured by different methods such as ELISA or immunoblotting. For clinical purposes the most important antinuclear antibodies are antibodies against double stranded DNA, Sm, RNP, SS-A, SS-B, centromere proteins and Jo-1. The importance of antinuclear antibodies lies in their disease-specific profiles which are helpful for diagnosis. At present, it is not known if antinuclear antibodies are involved in pathogenesis of connective tissue diseases.

Antibodies, Antinuclear↗
PubMedDate not supplied

[Isolated dissection of the posterior cerebral artery].

Two cases of isolated dissection of the posterior cerebral artery responsible for ischemic stroke are reported. Nine probable or certain additional cases were found in the literature. Most patients were female. The clinical presentation consisted of ischemic symptoms in 6 patients, subarachnoid hemorrhage in 4, and both symptoms in 1. Headache was present in almost all patients. The most prevalent angiographic picture was an eccentric stenosis followed by fusiform dilatation of the P1-P2 segments of the posterior cerebral artery. A double-lumen sign was observed in 3 cases. A favorable outcome was usual in cases with ischemic symptoms. Potential benefits from anticoagulants (in case of ischemic symptoms) or surgery (in case of subarachnoid hemorrhage) are unknown.

Adult↗