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Biomedical subjects

M de Campo

Publications and source records attributed to M de Campo.

6 recordsLinked to original sources

CT invertograms.

Direct sagittal CT can provide an accurate assessment of anorectal anomalies in selected patients. Images are easily obtained and enable direct imaging of the soft tissues of the rectum and anus.

Anal Canal

Glomerulocystic renal disease: ultrasound appearances.

Renal and hepatic sonography were performed in 2 neonates with glomerulocystic renal disease. One neonate had ultrasound findings of normal hypoechoic medullary pyramids, enabling differentiation from infantile polycystic renal disease. Previous case reports have highlighted the similarity of renal ultrasound findings in these two conditions.

Humans

Neonatal posterior fossa haemorrhage: a difficult ultrasound diagnosis.

Four newborn neonates with a history of birth trauma and significant neurological signs were examined with both ultrasound and computed tomography (CT) performed within hours of each other. Ultrasound was inadequate in initial assessment, as it missed or underestimated posterior fossa haemorrhage, particularly where this was extraparenchymal or vermian. CT is the examination of choice in these patients.

Cerebral Hemorrhage

Uses of direct coronal pelvic CT.

A technique for performing direct coronal computed tomography (CT) of the pelvis on conventional CT equipment is described. Eighteen patients have been examined by this technique and its possible applications in the evaluation of patients with anorectal and genitourinary anomalies, pre and postoperatively, are discussed.

Adolescent

Ultrasound of primary hepatic tumours in childhood.

Ultrasound scans of 18 children with primary hepatic tumours were reviewed to assess the accuracy of ultrasound in determining hepatic origin, extent, resectability, and histology. Using basic landmarks, ultrasound correctly predicted extent and resectability in 72% of patients. Accuracy would be increased by more detailed scanning to determine segmental and lobar landmarks. Hepatoblastoma demonstrated a characteristic appearance of a well-defined hyperechoic mass. Other tumour types showed some overlap in ultrasound appearances. Ultrasound examination overestimated the incidence of obliteration of the IVC lumen, and such patients require inferior venacavography to assess the true status of the cava preoperatively.

Bile Duct Neoplasms

A pedigree study of perinatally lethal renal disease.

A family study of perinatally lethal renal disease (PLRD) was undertaken in the State of Victoria, Australia, for the years 1961 to 1980. A total of 221 cases was ascertained through hospital and necropsy records and confirmed by necropsy findings. There were 134 cases of bilateral renal agenesis (BRA), 34 cases of unilateral agenesis with dysplasia of the other kidney (URA/RD), 42 cases of bilateral renal dysplasia (BRD), and 11 cases of renal aplasia. Parents of 131 babies were interviewed and 153 parents from 82 families had a renal ultrasound examination. In the period of best ascertainment (1975 to 1980) the frequency of PLRD was 0.27 per 1000 and of BRA 0.16 per 1000. There were 10 cases of sirenomelia, a frequency of 0.008 per 1000. For all families of PLRD, 15 of 423 (3.6%) sibs and three of 1579 (0.2%) first cousins were affected. One family had three sibs with BRA and four had two sibs with BRA. One pair of sibs and two first cousins had BRA in one and URA/RD in the other affected. One baby had BRD with an affected first cousin. The nature of the renal lesion was not established. When the index case had BRA, 14 in 283 (5.6%) sibs had PLRD. Where the index case had BRA and urogenital defects, but no birth defects in other organs, 12 of 148 sibs (8%) were affected. None of the sibs had BRA when the index case had BRA as part of a multiple malformation complex. In the multiple malformation group, however, five of 40 (12.5%) sibs had similar patterns of malformations. Renal ultrasound abnormalities were no more frequent in parents of two affected babies (one of 18) than in the other parents (nine of 135). Our findings confirm that BRA and URA are genetically related. There are a number of conclusions which are important for genetic counselling. There is a high likelihood of recurrence (8%) in sibs when the index case has BRA and urogenital abnormalities alone. When BRA is part of a multiple malformation complex, the risk of recurrence of multiple malformations is significant (12.5%), but risk recurrence of BRA is low. The finding of renal ultrasound abnormalities in the parents was not informative.

Abnormalities, Multiple