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M de Sousa

Publications and source records attributed to M de Sousa.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Imaging of lymphoid structures with indium-111-labeled lymphocytes.

The ability of indium-111 (111In)-oxine-labeled syngeneic lymphocytes to migrate normally and their suitability for imaging both normal lymphoid structures and those with metastatic disease were assessed. Sixty-two ACI rats were studied, 34 of which received injections in the left foot pad with 1 X 10(6) syngeneic H-4-II-E hepatoma cells nine to 44 days before imaging. Most animals were bearing palpable tumors when imaged. In 53 experiments, 1-6 X 10(8) 111In-oxine-labeled lymphocytes with a labeling concentration of 5-80 microCi/10(8) cells were injected intravenously. Gamma camera images were obtained 22 hours later. After the last image, the animals were killed. The lymph nodes, liver, spleen, lungs, and left femur were dissected, and the recovered radioactivity was determined in a gamma well counter. Lymph nodes could be partially or completely visualized in 70% of the animals (15 tumor-bearing and 16 normal out of 44 technically satisfactory experiments). Large metastatic nodes were seen clearly. Lymphocytes labeled with 111In-oxine exhibited a normal migration from blood to lymph nodes.

Animals↗
PubMedDate not supplied

[Aneurysm of the Valsalva sinus. Echocardiographic diagnosis. Apropos of a case of long post-rupture survival].

The authors present a case of aneurysm of the right sinus of Valsalva with rupture and aorto-cardiac shunt to the exit chamber of right ventricle. Based on clinical information, one can assume that it could be a case which has been with few symptoms for a period of seven years or more. The diagnosis was made possible due to the images obtained by M mode and two dimensional echocardiography, which allowed an unmistakable view of an aneurysmatic dilatation and the site of the rupture which was confirmed later by Doppler echocardiography with colour codification and and anatomical assessment at surgery.

Adult↗
PubMedDate not supplied

Adhesion molecule interaction with extracellular matrix.

The role of extracellular matrix (ECM) proteins in supporting tissue structure and modulating cell moltility or phagocytosis is well established. Recent demonstration of complex in vitro interactions between lymphocytes and ECM components mediated by an array of cell surface adhesion receptors supports the role ECM may play in physiological functioning of the immune system in vivo, e.g. cell activation, migration and positioning in specific tissue microenvironments. Thus, ECM components and their lymphocyte adhesion ligands should be considered as active participants in the host immune responses, including that triggered by transplantation of an MHC-incompatible organ graft.

Animals↗