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M de Vincentiis

Publications and source records attributed to M de Vincentiis.

34 records · Page 2Linked to original sources
PubMed1991

[Thyroid gland and carcinoma of the hypopharyngeal-laryngeal region].

The thyroid gland harbours many diseases which require a surgical treatment; the gland may also be involved by some secondary malignant neoplasms. Such type of involvement by laryngeal and hypopharyngeal cancers is more often due to direct extension rather than metastases. In this paper the Authors report their experience of tumoral involvement of the thyroid gland in 35 patients with laryngeal or hypopharyngeal cancer observed from 1986 to 1990. All patients had an epidermoid carcinoma of the larynx or hypopharynx that required an hemithyroidectomy (always plus isthmectomy) or an isthmectomy associated to laryngectomy. On pathologic examination 5 thyroid specimens revealed tumoral involvement in patients with laryngeal neoplasms: 1 case of solitary metastasis and 4 cases of direct extension. In patients with hypopharyngeal lesions, on the contrary, the gland was, in all cases, undamaged. For this very interesting and uncommon finding the Authors agree with Harrison's proposal suggesting total thyroidectomy is necessary in case of subglottic lesions while in all the other laryngeal and hypopharyngeal lesions the homolateral lobe of the thyroid gland and the isthmus should be removed with the specimen also performing a frozen section examination of the contralateral lobe. In this study tumoral involvement of the thyroid gland appeared to be a very important negative prognostic factor and was higher in the subglottic and anterior commissure lesions.

Aged↗
PubMed1986

Pulmonary resection for metastatic laryngeal carcinoma.

In a 5 year period, 11 patients were referred to our department as candidates for resection of pulmonary metastases from laryngeal carcinoma. At thoracotomy, a second primary tumor of the lung was discovered in three patients (27%). The other eight were considered eligible for thoracotomy and were subsequently proved to have metastases. Two of these patients (Group I) refused surgical treatment and died after 10 and 12 months; histologic diagnosis was obtained at autopsy. Six patients (Group II) underwent curative resection: Two of them have died (26 and 34 months) and four are alive and free of disease 40, 43, 46, and 55 months after thoracotomy. The disease-free interval, stage of primary tumor at laryngectomy, and single versus multiple metastases do not seem to affect survival. We conclude that lung resection increases survival in patients with pulmonary metastases from laryngeal carcinoma.

Aged↗
PubMed1985

X-ray microanalytical studies on cryofixed blood cells of the ascidian Phallusia mammillata. I. Elemental composition of morula cells.

Cryofixed blood morula cells of Phallusia mammillata (Cuvier), which are considered to be vanadium-accumulating cells, were examined by X-ray microanalysis using STEM (scanning transmission electron microscopy) and SEM (scanning electron microscopy). It is thought that cryopreparation preserves the native distribution of diffusible elements such as sodium, chlorine, and potassium, and prevents the displacement of vanadium, all of which may occur during conventional preparation. The results show that morula cell globules contain a large amount of sulphur and chlorine, and some sodium, magnesium, bromium and potassium, but very little or no vanadium.

Animals↗
PubMed1979

Ultrastructural localization of vanadium in the blood cells of Ascidiacea.

X-ray histospectrographic analysis at the scanning and transmission electron microscope (STEM) are made on the blood cells of Phallusia mamillata Cuvier and Ciona intestinalis, to study the 'direct' intracellular sites of accumulation of vanadium. The results show a clear accumulation of vanadium on the membrane and in the granules of vacuoles of amebocytes, signet ring cell, compartment cell and traces of metal in the 'vanadophores' of vanadocytes.

Animals↗
PubMed1977

[Variation of phosphagens in sea urchin eggs before and after fertilization].

Improved methods of separation, identification and determination of phosphagens have been applied to the study of monosubstituted guanidines and phosphagenes in sea urchin eggs, before and after fertilization. We have been able not only to identify in these materials phosphoarginine, but also phosphocreatine and to detect an unknown phosphagen. After fertilization, free arginine and creatine decrease, within respect to unfertilized eggs, whereas phosphocreatine undergoes a large increase; phosphoarginine remains almost constant, and an unknown phosphagen appears. These observations allow to interprete the results of some authors, who, applyng less refined methods, found only an increase in phosphoarginine in the same materials.

Animals↗
PubMedDate not supplied

[Functional recovery in subtotal laryngectomies].

Subtotal laryngectomy, a valid treatment for carefully selected patients, is a safe oncologic procedure which preserves the cricoid-arytenoid unit creating a successful "neo-larynx" with valid phonatory and deglutition functions. At the E.N.T. Clinic of "La Sapienza" University of Rome from Jan. 1984 to Feb. 1992, 85 subjects underwent subtotal laryngectomy, 50 of which then underwent phoniatric examination. The remaining patients were not suitable candidates because of the trachealis cannula (14), or because they were lost at follow up (16). A total of 50 male subjects were examined. Twenty-eight underwent crico-hyoid-pexia, while 22 patients underwent crico-hyoid-epiglotto-pexia. Attention is drawn to the results which appear to be extremely variable with regard to each study group. We obtained better results with crico-hyoid-epiglotto-pexia than with crico-hyoid-pexia and we guaranteed a good social re-insertion in all cases.

Aged↗
PubMedDate not supplied

[Surgical treatment of post-thyroidectomy laryngeal paralysis].

A not infrequent complication of thyroid surgery is laryngeal nerve palsy with transitory or permanent deficiency of cordal motility. A very frequent cause of this condition is total thyroidectomy. Peripheral mono-or bilateral palsy in these cases may either occur, in adduction or abduction, and be complete or not complete. Therefore, different strategies in order to restore respiratory and phonatory functions are required. The Authors describe the main otorhinolaryngologic procedures used for the surgical treatment of laryngeal palsy, particularly for bilateral adducted ones. Their 10-year experience is also reported.

Adolescent↗
PubMedDate not supplied

[Association of primary malignant neoplasms of the larynx and the lung. 12 years of clinical experience].

Laryngeal and pulmonary cancers present a certain agreement in regard to annual incidence. When studied separately these tumors show certain similarities and differences and they are of particular interest when they arise in the same subject. The association of laryngeal and pulmonary neoplasms is one of the most common associations among multiple primitive malignant tumors and represents an important problem in terms of prevention and diagnosis. The present study involves 18 cases of associated tumors observed from January 1, 1977 and December 31, 1988. All the subjects involved were males, average age 62 years, who had been treated for laryngeal cancers, mostly laryngeal epidermoid carcinoma. Pulmonary cancers (simultaneous, synchronous, metachronous) were diagnosed in all these subjects and one patient presented 2 autonomous bronchial lesions which arose in different periods. On the whole, 8 out of 18 patients (44.4%) are still alive and of these 6 (33%) enjoy good health more than 1 year after treatment for the pulmonary tumor. After reporting some considerations regarding the neoplastic association between the larynx and the lungs and about the increased risk of pulmonary neoplasm in those patients treated for supraglottic lesions, the authors hypothesize that these neoplasms are simultaneously present in both organs more frequently than previously thought. The authors assert that laryngeal tumor patients must be considered as a potential carrier of pulmonary cancer. Therefore, both before and after treatment (particularly in the first 6 months after surgery and/or radiotherapy) the patient must be carefully observed.

Adult↗
PubMedDate not supplied

[Early diagnosis of pulmonary tumors in patients treated for laryngeal cancer].

Multiple primary malignant neoplasms occur relatively frequently today and are quite important. If the primary tumor ("index tumor") develops in the upper aero-digestive tract, the incidence of these neoplasms ranges from 10 to 20%, especially in males. The most common second primary site is again in the upper aero-digestive tract and, less frequently, in the lungs or thoracic esophagus. Among head and neck tumors laryngeal cancer is certainly one of the neoplasms most often playing the role of index tumor in association with malignant cephalic and extracephalic tumors. Among the most frequent associations of multiple primary malignant tumors one finds: larynx-lung and larynx-esophagus. As a high incidence of metachronous primary pulmonary cancers were observed during follow-up of patients who had undergone laryngeal surgery, a preventive flexible bronchofiberscope study was performed in 101 patients who had undergone surgery for laryngeal cancer over the ten years period from 1978 to 1987. The patients had a median age of 58.7 years (range 42-81) and were prevalently males (98 males, 3 females). The incidence of second primary neoplasm in the lung was 3%. During this bronchoscopic study the chest x-ray for 2 of the 3 patients with second primary neoplasm in the lung was normal, all 3 had an evident familiar neoplastic predisposition, one had been treated for colon carcinoma prior to laryngectomy. The authors report some personal opinions regarding the larynx-lung neoplastic association and emphasize the application of bronchoscopy in following-up laryngeal cancer patients.

Adult↗
PubMedDate not supplied

[Latero-cervical adenopathies due to occult tumors: clinical experience and considerations on the therapeutic treatment].

The treatment of patients with occult primary tumors presenting cervical metastases is still controversial. Thus the treatment of 10 patients with cervical metastases from unknown primary sites observed from 1978 to 1987 is reviewed. The average age of these patients was 56 years with a male: female ratio of 9:1. Any patients previously treated for cephalic or extracephalic neoplasms were excluded from the study as were those with lymphomas. According to TNM classification (1978) 7 cases (70%) were N1, one (10%) was N2 and two (20%) were N3. Only in one case were the cervical metastases multiple and unilateral, in one case (N2) they were bilateral. Histopathological diagnosis was performed with open biopsy in all cases prior to radical or conservative neck dissection. Five patients (50%) had metastases from epidermoid carcinoma, two (20%) from undifferentiated carcinoma (non nasopharyngeal), one (10%) from a papillary thyroid carcinoma, one (10%) from undifferentiated nasopharyngeal carcinoma and one (10%) from adenocarcinoma. The neck locations of the metastases were as follows: 3 (30%) at the upper cervical nodes (as was the N2 case), 3 (30%) at the mid-jugular nodes, 1 (10%) at the lower cervical nodes, 1 (10%) at the supra-clavicular nodes and 1 (10%) at the jugulo-digastric node. In the only case of multiple and unilateral nodes (10%) a contemporary involvement of the mid-jugular and lower cervical nodes was observed. A complete history was taken and a general physical and E.N.T. examination, X-ray, radioisotope and endoscopic studies were performed for all patients. In all cases treatment was: surgery on N + radiation therapy on the most common sites of unknown primary tumors. In particular, 7 conservative neck dissections (bilateral in one case), 2 radical neck dissections and 1 modified radical neck dissection were performed. The survival rate was 60% at 3 years and 40% at 5 years; it may be due to the radical treatment and to the high number of N1 and epidermoid carcinomas. In conclusion some considerations about the treatment of this pathology were reported.

Adenocarcinoma↗
PubMedDate not supplied

[Environmental and occupational risk factors in keratosis of the larynx].

Laryngeal keratosis may frequently precede the appearance of carcinoma of the larynx which might well indicate that these diseases have a common denominator. A retrospective study of 120 subjects with laryngeal keratosis was examined. The intention of the Authors was to verify whether the principle risk factors involved in the appearance of laryngeal carcinoma were the same as those implicated in laryngeal keratosis formation. Sex age, work activity, cigarette smoke, alcohol consumption and vocal chord abuse were considered. Laryngeal keratosis takes keratosis with dysplasia as well as keratosis without. A link between these two types of keratosis and cancer was sought. In particular, the possibility that a persistent action of the mentioned risk factors could cause laryngeal dysplasia-free keratosis to change into dysplastic lesions and subsequently into cancer was investigated. A case-control study was performed in order to analyze the importance of work activity. Results were statistically significant (P < 0.001). The Cramer V2 calculation demonstrated a clear correlation between the number of cigarettes smoked and the appearance of dysplasia (V2 = 0.117; P < 0.005). Results showed a clearly different behaviour between sexes. The number of males was much higher than females as was the age at which keratosis appeared greater in males. The fact that the average age in which keratosis appeared preceded the appearance of laryngeal cancer by ten years indicates that this interrum is sufficient for keratosis with dysplasia to be transformed into cancer (due to the continued action of the mentioned etiologic factors, mainly referred to cigarette smoke). In our data analysis, no correlation was demonstrated between keratosis without dysplasia and cancer.

Adolescent↗