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Biomedical subjects

M van Blankenstein

Publications and source records attributed to M van Blankenstein.

At least 109 records · Page 6Linked to original sources
PubMed1983

Endogenous bile acid tolerance test for liver function.

Fasting and postprandial (stimulated) serum conjugated bile acids (CBA) were measured by a solid-phase radioimmunoassay in 329 patients undergoing liver biopsy, and the results were analyzed for 231 who fitted into 10 diagnostic categories. In healthy volunteers the mean fasting CBA of 1.8 +/- 0.7 mumol/liter rose to 3.0 +/- 0.8 mumol/liter postprandially. In patients mean fasting and stimulated CBA were only significantly raised in moderate to severe chronic and acute liver disease. Diagnostic sensitivity was poor in mild liver disease. Individuals with normal results were found in 8 of 11 disease categories. The ratio of stimulated to fasting CBA expressed in a stimulation quotient did not rise in more advanced liver disease. These findings are best explained by a constant fractional clearance of bile acids by the liver. We conclude that the serum conjugated bile acid determination as a test of liver cell function is not sensitive enough to identify all cases of biopsy-proven liver disease.

Bile Acids and Salts↗
PubMed1982

Factors determining the occurrence of serum agglutinins to eubacterium and peptostreptococcus species in patients with Crohn's disease and ulcerative colitis.

Recently, the demonstration of serum agglutinins to Eubacterium and Peptostreptococcus strains has been found to be useful as a diagnostic test for Crohn's disease. Therefore, conditions determining the occurrence of these antibodies were studied in patients with Crohn's disease and ulcerative colitis. Localization of Crohn's disease in the colon, the presence of fistulae and serum levels of immunoglobulins were found to be contributory determinants for the occurrence of the agglutinins.

Adolescent↗
PubMed1981

Intrahepatic cholestasis induced by phenylbutazone.

The case history of a woman with intrahepatic cholestasis is described. She had taken phenylbutazone during 1 month for painful swollen knees. A liver biopsy obtained at surgical exploration revealed pericentral cholestasis and infiltration of the portal spaces with lymphocytes and eosinophilic leucocytes, suggesting a drug reaction. Clinical and biochemical parameters returned to normal within 2 months. A provocation test with a single dose of phenylbutazone was performed 6 months after her recovery. On the 2nd day, a marked increase of serum transaminases and alkaline phosphatase was observed. Transaminases became normal within several days, whereas alkaline phosphatase remained elevated during a month. From these data we conclude that phenylbutazone can cause cholestatic jaundice probably as a result of a hypersensitivity reaction.

Cholestasis, Intrahepatic↗
PubMed1978

Abnormal blood vessels of the prepyloric antrum in cirrhosis of the liver as a cause of chronic gastrointestinal bleeding.

Three elderly females presenting with iron deficiency anaemia and faecal loss of blood were found to have a macronodular cirrhosis of the liver and an unusual red spotty appearence of the prepyloric antral mucosa. One patient underwent antral resection and the surgical specimen revealed abnormalities of the (sub)mucosal blood vessels. Anaemia and occult faecal blood loss disappeared after operation. It is suggested that this type of antral vascular abnormality is aetiologically related to hepatic cirrhosis and may represent a gastric equivalent of cutaneous spider angiomata.

Aged↗