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Biomedical subjects

M van Damme

Publications and source records attributed to M van Damme.

6 recordsLinked to original sources
PubMed1981

Toxicological analysis of phenylethylamines by high performance reversed-phase ion-pair partition thin-layer and liquid chromatographies.

A rapid and specific method was developed to identify phenylethylamines in urine. After an organic extraction at appropriate pH, reverse phase ion-pair partition chromatographies were used: a high performance thin-layer test followed by high performance liquid chromatography. The use and benefits of the procedure are described in detail and compared with other methods. In a very short time (10 min) the presence of phenylethylamine is detected on a thin-layer plate. In the case of positive result the product is then specifically identified by high performance liquid chromatography by means of a complete UV spectrum traced directly on the eluated compound. The sensitivity of the method is highly increased because the detection is operated at 215 nm.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

The pressure and flow distribution within a filtering capillary network.

A model is developed to estimate the parameters controlling glomerular function by network analysis. The topological and dimensional parameters are obtained by reconstructing a Wistar rat glomerulus. The model allows the calculation of blood and plasma flow distribution between the glomerular branches, their contribution to filtration and the drop of intracapillary hydrostatic pressure along the network. The program adjusts the blood flow distribution and the red cells partition at divergent nodes, the afferent intracapillary hydrostatic pressure and the hydrodynamic conductance of the glomerular wall in order to satisfy the following conditions. The intracapillary pressures at a convergent node must be the same whatever pathway is followed to reach that node; the mean integrated intracapillary hydrostatic pressure and the single nephron glomerular filtration rate must equal their experimental value. Convergence is obtained applying the Newton-Raphson method.

Animals↗