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Biomedical subjects

M van Holsbeeck

Publications and source records attributed to M van Holsbeeck.

31 records · Page 2Linked to original sources
PubMed1989

Soft tissue involvement, mediastinal pseudotumor, and venous thrombosis in pustulotic arthro-osteitis. A study of eight new cases.

A syndrome of hyperostosis of the thoracic wall, nonspecific signs of inflammatory disease, and palmar and plantar pustulosis is described in eight patients (Table 1). Seven had intersternocostoclavicular ossification, and one had chronic recurrent multifocal osteomyelitis. This complex of findings has been called "pustulotic arthro-osteitis". This report emphasizes the periosseous soft tissue inflammation and the unexplained subclavian and mediastinal vein thrombosis seen in two patients. Inflammatory periosseous and mediastinal lesions were seen on plain films in all eight patients and on computed tomographic (CT) scans in seven. Radiographs of the spine showed a spondyloarthropathy in three patients. This was characterized by ossification of the vertebral ligaments and sclerosis of the vertebral bodies. Awareness of the radiologic features of pustulotic arthro-osteitis is important because the clinical, biochemical and pathologic findings are often nonspecific and misleading.

Adult↗
PubMed1989

Imaging of meniscal cyst of the knee in three cases.

Three cases of solitary meniscal cyst in the knee have recently been diagnosed in our departments using ultrasound and nuclear magnetic resonance (MRI). Two cysts involved the lateral and one the medial meniscus. The appearance of these lesions on ultrasound and MR images is shown. All three cysts had low intensity on T1-weighted images and high intensity on T2-weighted images and clearly communicated with a large horizontal tear in the meniscus. Ultrasonography showed a relatively hypoechoic lesion and, in the two cases of lateral meniscal cyst, focal areas of relatively increased echoes which are probably due to meniscal debris. Ultrasound showed the abnormal meniscus in both of these cases. MRI is the best way of showing the cyst and an accompanying meniscal tear but, where MRI is not available, ultrasound may be an easy and inexpensive way of making a diagnosis whether or not it is used in conjunction with positive contrast arthrography.

Adult↗
PubMed1988

Staging and follow-up of rheumatoid arthritis of the knee. Comparison of sonography, thermography, and clinical assessment.

Twenty patients with longstanding polyarticular rheumatoid arthritis (including knee involvement) were selected for this study. The severity of the knee synovitis was assessed before and during treatment (with intra-articular corticosteroid injections) using clinical scores, sonography, and thermography. In all patients, the inflammation regressed during treatment. During follow-up, the quantity of synovial fluid, as measured sonographically 10 days after the start of therapy, correlated best with the clinical status. Maximal regression of synovial thickening was noted on delayed sonograms performed three months after treatment. Thermographic peak temperature showed good correlation with the clinical status, but the thermographic index was unreliable.

Adrenal Cortex Hormones↗
PubMed1987

Dorsal defect of the patella: concept of its origin and relationship with bipartite and multipartite patella.

In a series of 2286 single radiographic examinations of the knee in 1985, 6 dorsal defects of the patella (DDP) were detected. The diagnosis was made if a round lucent lesion of the dorsal superolateral surface of the patella was found abutting against articular cartilage. In four of our patients, an association with a multipartite patella (MP) was found. Biopsy of one lesion showed dense connective tissue and areas of bone necrosis. In one patient, the pattern of reossification of the lesion could be demonstrated. Our observations provide further evidence that the DDP is a stress-induced anomaly of ossification rather than a post-traumatic subarticular cyst of the patella, a diagnosis sometimes suggested by the clinical context. The initial lesion is probably a traction lesion at the insertion of the vastus lateralis muscle rather than ulceration of articular cartilage. We suggest a possible relationship between dysfunction of the quadriceps mechanism, patellar subluxation, and the genesis of the DDP.

Adolescent↗
PubMed1985

The sonographic aspects of haemobilia. Clinical and experimental study.

The sonographic aspect of the gallbladder in seven cases of haemobilia is analysed. The changes include a diffuse echogenic gallbladder content during the initial stage. Later, irregular shaped inhomogeneous non shadowing masses are seen in the dependent parts of the lumen. This variable aspect was studied in an experimental model by percutaneous injection of blood in the gallbladder of Guinea pigs. The hyperechoic gallbladder content, seen early after injection is a transitory phenomenon which seems related to red cell aggregation before coagulation occurs. During the later stage the intraluminal masses were shown by histology to represent bloodclots. In a patient the observation of such a rapid evolution from diffuse hyper-reflectivity to less reflective masses is strongly suggestive of haemobilia.

Animals↗
PubMedDate not supplied

Ultrasound for the early diagnosis of tibial fracture healing after static interlocked nailing without reaming: histologic correlation using a canine model.

OBJECTIVE: Ultrasound is thought to be clinically useful in evaluating bone formation through its presumed identification of fracture callus. However, documentation of the actual histology of the tissue identified by ultrasound has been lacking. The purpose of this study was to determine the histologic composition of the hyperechoic tissue "seen" by ultrasound. STUDY DESIGN: Unilateral fractures were created in eight canine tibias and then fixed by using locked intramedullary nailing without reaming. The limbs were studied at two, three, four, six, and eight weeks postoperatively with plain radiographs, ultrasound, and ultrasound-directed needle biopsy. RESULTS: The presence of a hyperechoic ultrasound signal was found to have a 100 percent correlation with the presence of hard fracture callus biopsy tissue. In addition, fracture union by ultrasound criteria significantly predated radiographic fracture union (5.6 vs. 7.3 weeks, p = 0.05). CONCLUSIONS: These results support and provide a scientific basis for the clinical use of ultrasound to assess tibial fracture healing following static interlocked nailing without reaming.

Animals↗
PubMedDate not supplied

Ultrasound for the early diagnosis of tibial fracture healing after static interlocked nailing without reaming: clinical results.

OBJECTIVE: Based on the results of a pilot study indicating the potential value of ultrasound (US) as a diagnostic tool for the early assessment of fracture healing and the related need for secondary operative procedures in patients treated by statically locked intramedullary (IM) nailing without reaming, a protocol was established for a larger scale prospective trial. The purpose of this study was to evaluate the outcome of this follow-up trial. DESIGN/METHODS: All skeletally mature patients admitted to the Henry Ford Hospital (Detroit, Michigan) from January 1993 to August 1994 who had sustained an acute fracture of the tibial shaft and who were treated by statically locked IM nailing, without reaming, were candidates for study. Forty-seven patients with fifty fractures that could be evaluated by US were included. The adopted determinants for fracture healing were complete disappearance of the IM nail on US examination performed at six weeks postoperatively, or progressive disappearance of the nail noted between the initial six-week study and a second nine-week US examination, both in conjunction with periosteal callus formation. Radiographs were obtained to monitor maintenance of reduction and to further evaluate fracture healing. RESULTS: Of thirty-eight fractures with a positive US (thirty-two at six weeks, six at nine weeks), thirty-seven healed uneventfully, a positive predictive value of 97 percent. Radiographic fracture healing was not evident until, on average, nineteen weeks after injury. The single false-positive fracture progressed to nonunion. Of the twelve fractures with negative US studies, ten underwent secondary procedures (nine dynamization, one bone graft), with four progressing to nonunion. Two patients refused secondary surgery; screw failure occurred in both. Otherwise, there were no hardware failures in this series. CONCLUSIONS: The results of this study indicate that US may provide important prognostic information concerning fracture healing after unreamed tibial nailing, upon which subsequent treatment can be based.

Adolescent↗