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Biomedical subjects

M van Wijhe

Publications and source records attributed to M van Wijhe.

7 recordsLinked to original sources

[Chronic orofacial pain; atypical facial pain?].

Difficult to diagnose pain in the orofacial area may be a challenge to the dental practitioner. There still is uncertainty about the taxonomy of chronic orofacial pain, and even more so about its etiology. Treatment of chronic orofacial pain may aim at goals which are set in advance, but also at the underlying pain mechanisms. The disentanglement of pain into different pain mechanisms may be facilitated by applying a pharmacodiagnostic test. This test consists of intravenously administering several medications in low doses in orofacial pain patients. The response to the administration of these pharmaca is reported by means of a visual analogue scale (VAS) for pain. The profile, resulting from the consecutive VAS-scores, may be used as a guide for further treatment. Before the start of any treatment, the dentist should judge whether he himself is able to treat the patient or referral to a specialist is required.

Chronic Disease↗

Midazolam versus fentanyl/droperidol and placebo as intramuscular premedicant.

Midazolam, a new short-acting benzodiazepine with promising premedicant effects, was investigated in a double-blind, randomized clinical trial in 203 patients versus fentanyl/droperidol and placebo. Subjective effects, side-effects, amnesia and overall satisfaction were recorded. Midazolam caused the greatest decrease in anxiety level, and while causing more confusion and somnolence than placebo, caused less confusion and somnolence than fentanyl/droperidol. Half the patients who received midazolam reported anterograde amnesia. No serious side-effects were reported. Patient satisfaction was greater in the midazolam group than in the other groups.

Adolescent↗

[2 cases of sympathetic paraganglioma of the urinary bladder].

Two cases of symphathetic paraganglioma of the urinary bladder are reported. Symppathetic- or parasymphatetic origin of intramural paraganlia or paragangliomas can be determined by demonstration of praesynaptic myelinated fibers. This method gives more reliable results than formaldehyd-induction-method carried out on freezed sections or the Gömöri's chromaffin reaction which often appears to be false-negative.

Chromaffin Granules↗