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ME Morris

Publications and source records attributed to ME Morris.

3 recordsLinked to original sources
PubMed1999

Rapid Solubility Determination Using Vapor-Phase Osmometry.

Because of the need for resource-sparing assays of the solubility of new drug candidates, we sought to develop and validate a rapid method for determining the solubility of nonvolatile pharmaceutical solids in water. Vapor-phase osmometry was used to determine the concentration of drugs in saturated solutions prepared by a rapid ultrasound-mediated dissolution protocol. The osmolality of saturated solutions as measured by the vapor-phase osmometer is an excellent predictor of the solubility of pharmaceutical solids in water. Each osmolality measurement requires less than 10 µl of saturated solution and takes less than 2 min to complete. For small-molecule drugs with solubilities greater than 10 g/kg, osmometry may prove to be a rapid and accurate method for determining the water solubilities of drugs.

Journal Article↗
PubMed1998

Lateral pelvic displacement during walking: retest reliability of a new method of measurement.

This study examined the retest reliability of a new method of measuring the amplitude and symmetry of lateral pelvic displacement (LPD) during walking. Previous methods of quantifying LPD did not consider variations in walking direction or enable quantification of side-to-side symmetry of LPD. Therefore, the new method was developed to measure the amplitude and symmetry of LPD relative to the base of support provided by the feet. Three-dimensional motion analysis was used to collect the coordinates of markers placed on the sacrum and heels of 20 unimpaired adults. Subjects performed three 10 m walking trials at their preferred speed. Between trial 1 and 2 the markers were removed and then reattached. Between trial 2 and 3 the markers remained attached. Retest reliability was high for consecutive measurements of amplitude of LPD (ICC (2,1)=0.91), and marker reattachment did not affect the degree of reliability (ICC (2,1)=0.94). The reliability was also high for consecutive measurements of symmetry of LPD (ICC (2,1)=0.80). Marker reattachment did however reduce the reliability of symmetry measures (ICC (2,1)=0.54). This study provides data on the retest reliability of a new method of measuring LPD in unimpaired subjects against which the performance of patients can be compared. Copyright 1998 Elsevier Science B.V. All rights reserved

Journal Article↗