Biomedical subjects
Publications and source records attributed to Małgorzata Baumert.
This study shows present knowledge on the role of nitric oxide (NO)--a reactive gas that functions both as a signaling molecule in endothelial cells and nerve cells and as a killer molecule. The article also presents how we can use NO in treatment.
We investigated leptin concentration in umbilical cord blood of 51 newborns (mean 5.71 +/- 3.28 ng/ml) and in maternal blood (mean 22.11 +/- 10.95 ng/ml). Leptin concentration in 20 preterm infants (mean 4.73 +/- 2.15 ng/ml) was significantly lower (p < 0.05) than in full-term newborns (mean 6.34 +/- 2.08 ng/ml) and tended to increase according to gestational age and birth weight. We suggested leptin concentration had a role in intrauterine development.
We measured plasma concentration of endothelin-1 (ET-1), nitric oxide metabolites (NOx) and von Willebrand factor (vWF) in maternal and umbilical cord blood in 11 spontaneous (SN), 11 elective cesarean section (CC) and 13 preterm deliveries. Plasma concentrations of ET-1 in umbilical cord blood of preterm infants and systemic blood withdrawn 4 days after birth was higher then in respective healthy infants delivered by natural forces or elective cesarean section. Positive correlation were found between ET-1 and NOx (p < 0.05) and between ET-1 and vWF (p < 0.05) in maternal blood with preterm delivery. In umbilical cord of preterm infants a negative correlation between ET-1 and Apgar score was noticed. Higher concentrations of ET-1, NOx and vWF found in umbilical cord blood of preterm infants as compared with respective values assessed in healthy infants delivered per vaginam or by cesarean section respectively seem to be induced by hypoxia.