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Małgorzata Klimek

Publications and source records attributed to Małgorzata Klimek.

6 recordsLinked to original sources
PubMed2005

[Psychomotor development at the age of 5-7 years of very low birth weight infants].

BACKGROUND: Very low birth weight (VLBW) infants are at greater risk for neurodevelopmental delay, cerebral palsy (CP), vision and hearing impairment, and cognitive and emotional problems. The aim of the study was assessment of neurodevelopmental outcomes at the age of 5-7 years among VLBW infants and evaluation of prognostic value of selected perinatal risk factors. MATERIAL AND METHODS: A sample of 73 VLBW infants with mean birtweight 1075g and mean gestational age 28.9 weeks were evaluated. Infants were divided into 3 groups: (A) normal development (n = 35; 48%), (B) mild-to-moderate impairment (IQ 68-83, or mild to moderate hearing loss or visual problems, or mild/moderate CP or ADHD) (n = 25; 36%) and (C) severe impairment (IQ < 68, deafness, blindness or severe CP) (n = 13; 18%) RESULTS: The studied groups differ in respect to: gestational age (mean +/- SEM: 29.7 +/- 2.3 vs 28.1 +/- 2.5 vs 28.5 +/- 2.3 wks; p = 0.03), prevalence of retinopathy (ROP) (17 vs 28 vs 69%; p < 0.01), bronchopulmonary dysplasia (BPD) (31 vs 17 vs 62%; p = 0.03) and periventricular leukomalacia (PVL) (3 vs 0 vs 23%; p < 0.02). Maximum bilirubin concentration was higher in children with severe impairment (mean +/- SEM: 177 +/- 60 vs 193 +/- 45 vs 229 +/- 48 micromol/l; p < 0.05). On multivariate logistic regression analysis, factors associated with developmental impairment were serum bilirubin > or = 200 micromol/ I and ROP. CONCLUSIONS: The significant risk factors of poor neuro-developmental outcomes at the age of 5-7 years among VLBW infants are: gestational age, PVL, ROP, BPD and serum bilirubin concentration > 200 micromol/I.

Child↗
PubMed2004

[Patients with advanced ovarian cancer after negative second-look laparoscopy--follow up study].

OBJECTIVES: Follow-up in 65 patients with stage III-IV ovarian cancer after negative second-look laparotomy. Prognostic factors and causes of failure were also discussed. MATERIAL AND METHODS: 65 patients with ovarian cancer stage III-IV were treated with surgery and at least six courses of chemotherapy (cisplatin, adriamycin, cyclophosphamide) and second-look laparotomy. Results of the treatment are presented in a form of 5-year NED (no evidence of disease) survival. Dependence between analyzed factors and survival was assessment based on proportional hazard Cox model. RESULTS: In 30 patients (46.1%) recurrence during 5 year follow-up was observed. In 28 patients out of them (93.3%) it was loco-regional failure and in 2 patients distant metastases were the sole reason of unsuccessful results of the treatment. Adverse prognostic factors found in statistical analysis were: advanced primary stage, residual infiltrations after first laparotomy exceeding 2 cm and low grade of differentiation. CONCLUSIONS: 1. In about 50% of patient with advanced ovarian cancer loco-regional recurrence was observed, 2. Adverse prognostic factors were: advanced primary stage, residual masses after first laparotomy above 2 cm and low grade of differentiation.

Adult↗
PubMed2002

[Postnatal growth of very low birth weight infants. Anthropometry at two year of age: a longitudinal study].

BACKGROUND: The growth rate is an important indicator of the child's health state. Premature newborns require an especially exact and reliable assessment of their growth which should include, above all, their maturity. AIM: The evaluation of the influence of newborn's maturity on its growth rate during 2 first years of life. MATERIAL AND METHODS: Prospective, longitudinal cohort study. 159 newborns born < or = 32 weeks of gestation discharged from 3rd level NICU were divided into 2 cohorts: A) born between 24-28 weeks (n = 83) and B) born between 29-32 weeks (n = 76). Before discharge and then every month in the 1st year of life and every 3 months in the 2nd year of life weight, length, head circumference and chest circumference were measured. RESULTS: Median length in 6th month was 622 mm in group A and 650 mm in group B (p < 0.05), after 1 year 720 mm vs 745 mm (p < 0.05), and after 2 years 819 mm vs 853 mm (p < 0.05). Median weight was 6010 vs 7160 g (p < 0.05), 8210 vs 9410 g and 9965 vs 11,260 g (p < 0.05), median chest circumference 40 vs 42 cm (p < 0.05), 44 vs 46 cm (p < 0.05) and 46 vs 47.5 cm (p < 0.05) and median head circumference 42 vs 43 cm (p < 0.05), 45 vs 46 cm (p < 0.05) i 47 vs 48 cm (p = 0.06). The results were also presented as growth charts. CONCLUSIONS: The newborns born between 29-32 week of gestation have faster growth rate than newborns born between 24-28 week of gestation. The assessment of development of extremely premature newborns should be based on growth charts prepared separately for a given gestational age.

Anthropometry↗
PubMed2002

[A case of multiple malignancies].

A case of fourfold cancer: of the vulva and larynx diagnosed synchronously and the breast and lung diagnosed metachronously is presented.

Aged↗
PubMedDate not supplied

[Somatic and psychomotor development of preterm infants at the age of 2 years, with and without bronchopulmonary dysplasia].

OBJECTIVE: The assessment of psychomotor and somatic development at the age of 2 years of preterm infants with and without bronchopulmonary dysplasia (BPD). DESIGN: Case -- control study. SETTING: Neonatal Intensive Care Unit, University Hospital. MATERIAL AND METHODS: 62 preterm infants born before 32 weeks of gestation, with mean birth weight equaled to 1112 g were included into 2 groups: group A -- with BPD (n=31), group B (control) -- matched by sex, birth weight, gestational age (n=31). INTERVENTIONS: Evaluation of reaching milestones, neurological examination at 3, 9, 12, 18-24 months, Psyche-Cattel tests at 12 and 24 months, hearing and visions examinations, head, chest circumference, length and weight at 3, 6, 9, 12 and 24 months. MAIN OUTCOME MEASURES: Age of unsupported sitting and walking, intelligence quotient (IQ), cerebral palsy, hearing and sight impairment. RESULTS: Reaching motor milestones were similar in the both groups (unsupported sitting (mean) 10.4 vs. 8.7 months, unsupported walking: 15.1 vs. 13.9 months). Cerebral palsy occurred more (non-significantly) frequently in group A than in group B (7/31 vs. 2/31, p=0.15). Significantly lower IQ was found in group A at the age of 1 year in comparison with group B (x +/- SEM: 79.9 +/- 2.1 vs. 86.1 +/- 1.5, p=0.03) and at the age of 2 years (x +/- SEM: 89.2 +/- 2.7 vs. 96.0 +/- 2.1, p=0.06). Weight, length, head and chest circumferences at the term of delivery were similar in the both groups, but at the age of 9 and 24 months the group A children weighted less than group B (respectively: 7432 vs. 8128 g, 10010 vs. 11116; p<0.05) and at the age of 24 months were significantly shorter (816 vs. 848 mm, p=0.04). CONCLUSIONS: Bronchopulmonary dysplasia significantly influences intellectual and somatic development of preterm newborns.

Bronchopulmonary Dysplasia↗