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Biomedical subjects

Małgorzata Mrugacz

Publications and source records attributed to Małgorzata Mrugacz.

At least 19 recordsLinked to original sources
PubMed2006

[The evaluation of the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis].

PURPOSE: To investigate the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelialcells of patients with cystic fibrosis. MATERIAL AND METHODS: 15 patients with cystic fibrosis and 15 control subjects were included in this study. Impression cytology specimens were collected and analyzed by flow cytometry and analyzed by flow cytometry. RESULTS: A significant increase of ICAM-1 expression by epithelial cells was found in patients with cystic fibrosis compared with normal eyes. CONCLUSIONS: Increase of ICAM-1 expression by epithelial cells in cystic fibrosis patients suggests, that the inflammation appears to have a role in the pathogenesis of the ocular surface changes and may be a marker of the inflammatory status in cystic fibrosis.

Adolescent↗
PubMed2006

[Concentration of interleukine-8 in tears in patients with cystic fibrosis].

PURPOSE: To evaluate IL-8 concentration in tears fluid in cystic fibrosis patients. MATERIAL AND METHODS: Tears samples were collected from 18 CF Patients and 18 normal controls. Cytokine level was determined by ELISA. RESULTS: A significant increase of IL-8 concentration in tears fluid was found in CF patients compared with controls. CONCLUSIONS: Increase IL-8 concentration in tears fluid in CF patients suggests a role of immunologic processes in the pathogenesis of the ocular changes, and may be a marker of the inflammatory status in ocular surface in cystic fibrosis.

Adolescent↗
PubMed2005

[Measurement of retinal thickness using optical coherence tomography in patients with myopia].

PURPOSE: Measurement of retinal thickness using optical coherence tomography in patients with myopia. MATERIAL AND METHODS: 39 patients, 23 girls and 16 boys, aged 14-18 years, were included in the study. Control group consisted of 18 patients. Each patient was subjected to routine ophthalmic investigations, which included the assessment of visual acuity for near and distant objects, autorefractometer, intraocular pressure measurement, biometry, static visual field. The macular retinal thickness was measured using the optical coherence tomograph (OCT). RESULTS: The mean macular retinal thickness in the eyes with low myopia was 162.0 microm, with medium myopia 158.5 micro, while in high myopia 125.0 microm. A statistical correlation was found between the retinal thickness in high myopia patients and in the control group. CONCLUSIONS: Optical coherence tomography can be employed to assess the retinal thickness and thus facilitate the observation of the evolution of alterations in myopia.

Adolescent↗
PubMed2005

[Evaluation of the tears secretion in young patients with cystic fibrosis].

PURPOSE: Evaluation of the secretion of the tears in young CF patients. MATERIAL AND METHODS: We examined group of 18 CF patients and control group of 18 patients. The patients were evaluated systemically and examined for surface changes and Schirmer test. RESULTS: We observed abnormal Schirmer test in 81% of CF patients. The mean value of Schirmer test was 9.6 +/- 5.5 mm in the CF group and 25.0 +/- 3.0 mm in the control group. The difference was statistically significant. CONCLUSIONS: The cystic fibrosis patients have the hyposecretion of tear fluid. Schirmer test may be used in evaluation, diagnosis and treatment of the ocular changes in CF patients.

Adolescent↗
PubMed2005

[Hypertensive retinopathy in child with pheochromocytoma].

AIM: Pheochromocytoma is a tumor secreting catecholamines, it occurs in different age, rarely in children. The disorder coexists with malignant arterial hypertension. We present a case of patient with ophthalmic alterations in the course of pheochromocytoma. MATERIAL AND METHODS: In 12-year old boy operated on pheochromocytoma full ophthalmic examination, fluorescent angiography and ERG were performed. RESULTS: We found decreased visual acuity, hypertensive retinopathy and the scotopic and fotopic ERG alterations. CONCLUSIONS: Hypertensive retinopathy in the course of pheochromocytoma could be the first symptom of the disease, especially in children. The earlier this disorder is diagnosed and operated on, the better is the prognosis for health and regression of retinal findings.

Adrenal Gland Neoplasms↗
PubMed2005

[HLA-DR antigen expression on conjunctival epithelial cells in patients with dry eye].

PURPOSE: The aim of this study was to investigate the expression of HLA-DR antigen on conjunctival epithelial cells from patients with dry eye. MATERIAL AND METHODS: Ophthalmic examination and dry eye diagnostic tests were performed. Impression cytology specimens were collected in thirty patients with dry eye and in thirty people of control group. Conjunctival epithelial cells were processed for flow cytometry, by using monoclonal antibodies to HLA-DR. RESULTS: A significant increase of HLA-DR expression on epithelial cells was found in patients with dry eye compared with normal eyes. We also found positive correlation of increased expression HLA-DR with ocular complaints and diagnostic tests for dry eye such as Schirmer test, FBUT and lissamine green staining. CONCLUSIONS: These results confirm the presence of immunological processes in the pathogenesis of dry eye syndrome. Increased expression of HLA-DR antigen positively correlates with the parameters of dry eye diagnostic tests. HLA-DR measurement might be a useful method for monitoring inflammatory conjunctival changes in this disorder.

Adult↗
PubMed2005

[IFN-gamma in tear fluid in patients with cystic fibrosis].

PURPOSE: To evaluate IFN-gamma concentration in tear fluid in CF patients. MATERIAL AND METHODS: Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA. RESULTS: The concentration of IFN-gamma in tear fluid in CF patients was 10.75+/-2.23 pg/ml, and 4.06+/-0.57 pg/ml in control group. CONCLUSIONS: The results of this study indicate that increased concentration of IFN-gamma in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.

Adolescent↗
PubMed2005

[High myopia as a pathognomonic sign in Stickler's syndrome].

Stickler's syndrome is an autosomal dominant inherited disorder of connective tissue related to incorrect collagen structure. The changes include ocular, hearing, and joint and bone abnormalities. We present a case of 6-years-old patient with Stickler's syndrome, with characteristic features.

Child↗
PubMed2005

Dry eye syndrome and cataract as ocular manifestations of Crohn's disease.

PURPOSE: Crohn's disease is disorder classified under inflammatory bowel disease. Apart from the classic features of the inflamed bowel, patients may develop widespread systemic manifestations, including ocular changes. The authors present a case of ocular complaints in patient with Crohn's disease. MATERIAL AND METHODS: Case report of 11-year-old girl with Crohn's disease. We perform complete ophthalmologic examination and dry eye syndrome tests. RESULTS: A female patient with symptoms of dry eye syndrome and cataract in the both eyes was reported. CONCLUSIONS: Crohn's disease may be associated with ocular findings, such dry eye syndrome and cataract. Evaluation of the eye should be a routine component in the care of patients with Crohn's disease.

Anti-Bacterial Agents↗
PubMed2005

[Neuronal and hormonal regulatory mechanisms of tears production and secretion].

The ocular surface, tear film, lacrimal glands act as a functional unit to preserve the quality of the refractive surface of the eye, and to resist injury and protect the eye against bodily and environmental conditions. Homeostasis of this functional unit involves neuronal and hormonal regulatory mechanisms. The eye appears to be a target organ for sex hormones particulary the androgen, as they modulate the immune system and trophic functions of the lacrimal and Meibomian glands.

Androgens↗
PubMed2005

[Immunological aspects of tear fluid].

The eye is linked to the common mucosal immune system. This system play the part in preservation of the ocular surface. Tear fluid contains pro and anty-inflammatory factors such as lactoferrin, plasmin, immunoglobulins, and a lot of cytokines (interleukins, GM-CSF, TGF alfa and beta). The cornea is immunologicaly preferred, as a result of lack of resident lymphoreticular cells.

Cytokines↗
PubMed2004

[Optical coherence tomography in diagnosis of retinal diseases in children and adolescents].

This report describes the new optical technique of optical coherence tomography (OCT) for imaging eye fundus. OCT is noninvasive, capable of high-resolution of 10 to 17 microns imaging of biological tissue. It has been used, to investigate several ocular diseases in children and adolescents. These include macular disease, glaucoma, optic nerve disorders, and myopia.

Adolescent↗
PubMed2004

[Pulsatile ocular blood flow in patients with juvenile glaucoma].

PURPOSE: To compare ocular blood flow in patients with glaucoma juvenile and in normal subjects. MATERIAL AND METHODS: 20 glaucoma juvenile subjects and 20 persons as a control group aged 13 and 17, were matched for intraocular pressure and pulsatile ocular blood flow using pulsatile ocular blood flow (POBF). RESULTS: A positive correlation was found between ocular blood flow in patients with glaucoma juvenile and normal subjects. CONCLUSIONS: 1) POBF is a new and simple tool for the measurement intraocular pressure and pulsatile ocular blood flow and may be useful for diagnosis of the glaucoma. 2) We found a significant difference between ocular blood flow in glaucoma juvenile patients and normal subjects.

Adolescent↗
PubMed2004

[The effectiveness of latanoprost for the treatment of pediatric glaucoma].

Latanoprost is a prostaglandin F2alpha analog that reduces intraocular pressure by 20-40% in adults with open-angle glaucoma. The efficacy and safety of this drug in children has not been widely reported. In our study we evaluated the effect of latanoprost in 14 children aged 12-18 years (mean 15 years): 10 patients with glaucoma juvenile (I group); 2 patients with secondary glaucoma because of uveitis recidivans and 2 patients with aniridia and albinismus (II group). In the I group the average IOP decrement was 9 mmHg or 36.5% (range 29-44%). In the II group the average IOP decrement was 6.5 mmHg or 23.5% (range 11-33%). In one child with aniridia after one year of treatment IOL rose again to 26 mmHg and antiglaucomatous surgery was necessary. Ocular side effects in children of latanoprost are mild.

Adolescent↗
PubMed2004

[MCA/MR anomaly--case report].

PURPOSE: MCA/MR (Cohen syndrome) is a multiple congenital anomalies retardation syndrome with autosomal recessive inheritance. The clinical criteria are nonspecific. The diagnosis was based on the triad: hypotonia, truncal obesity and prominent central incisors. Added to the clinical spectrum ophthalmologic findings such as antymongoloid eye slant and retinal changes, are very important to diagnosis. MATERIAL AND METHOD: The authors present a case of 11-year-old boy with MCA/MR. RESULTS: In this patient we found decreased visual acuity, myopia and retinal abnormalities. CONCLUSIONS: Cohen syndrome is a congenital anomaly with general and ophthalmological findings.

Abnormalities, Multiple↗
PubMed2004

[Stickler syndrome--case report].

Stickler syndrome is an autosomal-dominant inherited disorder of connective tissue related to incorrect collagen structure. Characteristic signs include ocular, hearing, and joint and bone abnormalities. It is hard to assess morbidity of Polish population because of lack of full syndrome's expression. In this paper we report 6 years old boy, who presented features, first characterized by Stickler in 1965.

Bone Diseases↗