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Małgorzata Tafil-Klawe

Publications and source records attributed to Małgorzata Tafil-Klawe.

8 recordsLinked to original sources
PubMed2004

[What is the origin of cerebral aneurysms?].

Authors reviewed the literature on the ethology of saccular cerebral aneurysms. Nowadays the theories about inborn origin of the aneurysms are refuted. Numerous factors are involved in their formation. Two considered groups of the factors are the following: the hemodynamic ones and the ones related to particular cerebral artery histology. The first group comprises arterial hypertension and arterial blood flow disturbances in the brain. They increase the hemodynamic stress on arterial bifurcations. It has been also proven in the regions that the stagnation of blood flow may take place. It may induce a local arterial wall injury which may be caused either by anoxemic mechanism or by the release mediators from blood cells. The main factor in the second group is the particular make up cerebral artery walls, especially regions around their bifurcations, where a predominance of collagen fibers over elastic ones is found in connection with poorly developed muscular layer. The existing defects may be enhanced by disturbances in the process of connective tissue proteins synthesis which may be influenced by numerous endo- and exogenic factors. Apart from the genetic ones they may include: poisons like heavy metals and toxins present in cigarette smoke, medicines and hormones, especially steroidal ones. Unfortunately, experimental studies documenting the interdependencies between those substances and aneurysms are still scarce. Statistically proven risk factors of the malformations include: cigarette smoking, untreated arterial hypertension, female gender, collagen synthesis disturbances, and any disturbances in cerebral blood flow.

Cerebral Arteries↗
PubMed2003

[Is the brain a postmitotic organ? -- current knowledge on neural stem cells].

All the attempts for regeneration in the central nervous system (in clinical conditions) are still a failure. Hence the bulk of clinicists are convinced that the brain is a postmitotic organ. Are the pessimists right? In the recent few years some knowledge break-throughs have been made. It has been noticed in many places of adult mammals' brains there are cells capable of proliferating, including asymmetric divisions, and differentiating into neurons and glia when suitably stimulated. Such cells, called neural stem cells, are present also in the brains of adult humans, especially in the subventricular zone. It has been recently discovered that also cells derived from bone marrow are capable of differentiating into neurons. The authors reviewed world-wide literature devoted to this topic. They focused mainly on the biology of the newly discovered cells, and especially on their mitotic and differentiating potential. The authors critically assess the discoveries discussed.

Brain↗
PubMed2003

[Neural stem cells: perspectives of clinical application].

The prognosis for many patients with central nervous system (CNS) diseases has recently improved, especially due to enormous development of medical sciences. Nevertheless there are still pathologies very difficult to cure. It is caused mainly by the irreversibility of CNS lesions, that even after ceasing the primary pathological process--lead to deep functional deterioration. Hopefully this will change in the future thanks to the discovery of the stem cell population located in the CNS. These cells have to reproduce cytoarchitecture and CNS function. The range of possible use of the therapy based on neural stem cells (NSC) appears unlimited. The most advanced laboratory trials are focused on neurodegenerative diseases with very promising results The second field of clinical neuroscience that NSC can play a key role in are injuries of the CNS, with special emphasis on spinal cord injuries which are still an unresolved problem of neurotraumatology. Adding to the possible roles of NSC--they may act as transporters of transgenes in case of metabolic or neoplasmatic diseases. The interest of many groups of scientists in biological and clinical use of NSC appears to be justified. Authors present advancement and possible ways of development of therapeutic methods based on NSC.

Humans↗
PubMed2003

[Misdirected nerve regeneration: clinical implications].

Although peripheral nerve regeneration is not a precise renewal of primary connections, it often leads to successful return of their function. Moreover, in some cases, an injured nerve is aimly stitched to another one. A good example of such a procedure is intercostal neurotization of avulsed brachial plexus. Despite the fact that neural centers are not primarily suitable for their new function, they often fulfill it successfully. This respecification of function requires some changes in the central nervous system called "plasticity". Discussed are the potential mechanisms controlling these changes. The role of hypothetic proteins reversely transported from the target organ to the neuron's body, proprioceptive fibers and volitional control is mentioned. The punctual understanding of these mechanisms may appear not only very scientifically wonderful but also useful in clinical practice.

Humans↗
PubMed2003

[Eating disorders among students of the Medical University in Bydgoszcz].

There are many reasons of eating disorders among young people. The goal of our research was to determine factors related with poor nutritional habits in the group of 385 students of various departments of Bydgoszcz Medical Academy. The research was carried on with the help of a questionnaire regarding eating habits (EAT26) and a second questionnaire by Starzyńska, implicating the score of daily menu. The Body Mass Index (BMI) was calculated for all of the probed students. Eating disorder predispositions appeared in the group of 48 persons (12.4% of studied population), among them were 32 women and 1 man. An underweight (BMI < 18.5)--13 persons, overweight (25 < BMI < 29.9)--5 persons and BMI within normal limits--30 persons. More than a half of probed students were terrified by the reflection of being overweighted. Some other had like eating attacks and vomitings after eating (14 persons). A valuation of a probed persons diet indicates many nutritional habit faults.

Adult↗
PubMed2002

Ozone therapy and the activity of selected lysosomal enzymes in blood serum of patients with lower limb ischaemia associated with obliterative atheromatosis.

BACKGROUND: The paper compares the effects of ozone therapy and conventional balneological methods on health condition of patients with obliterative atheromatosis and on serum activity of three lysosomal enzymes. MATERIAL/METHODS: Sixty-four patients with lower limb ischaemia in the course of obliterative atheromatosis (without diabetes) were enrolled in the study. Thirty-two patients were treated with ozone administered by intravenous infusions and 30-minute aerosol oxygen-ozone baths. A comparative group was formed of 32 patients treated with traditional balneology. There was also a control group made up of 30 healthy subjects. Ozone therapy as well as traditional balneology were administered daily for the period of 10 days, excluding Saturdays and Sundays. Blood for biochemical analysis was collected from elbow vein in the following time intervals: 24 hours before ozone therapy or classical balneology, one hour after therapy and on the 10th day of treatment. The activity of cathepsin D, acid phosphatase and arylsulphatase as well as the levels of a-1-antitrypsin (protease inhibitor) were determined in blood serum of patients with obliterative atheromatosis. RESULTS: In patients who received ozone therapy the activity of analysed lysosomal hydrolases returned to the values typical for healthy subjects. Patients' general condition also improved. The use of traditional balneological methods did not result in any significant change either in the activity of lysosomal hydrolases, the level of a-1-antitrypsin or general condition of patients. CONCLUSIONS: Ozone therapy administered by intravenous infusions and aerosol oxygen-ozone baths of lower extremities yields much better therapeutic results in comparison with classical balneology.

Acid Phosphatase↗
PubMedDate not supplied

[Changes of sleep quality and mood disorders under the influence of phototherapy in patients with seasonal affective disorders SAD].

UNLABELLED: Major depression, seasonal pattern (seasonal affective disorder SAD) characterize the winter recurrence depressive episodes with remission of symptoms in spring and summer. Patients with winter depression report hypersomnia, fatigue, loss of energy, carbohydrate craving, appetite and weight gain. AIM: The aim of this study was to assess the effect of phototherapy on the quality of sleep parameters and subjective estimation of mood disorders in patients with seasonal affective disorders. METHOD: The investigated group consisted of 17 patients with SAD (15 female, 2 male) aged 18-64 (mean 38+/-12) years. Phototherapy (bright light therapy) was applied for 14 days, everyday morning--30 minutes, between 6.00 to 10.00--exposition to light of about 10,000 lux intensity. Polysomnogram (sleep EEG) was recorded before and after treatment. RESULTS: After phototherapy patients reported a significant mood improvement (57%) measured by the Seasonal Pattern Assessment Questionnaire. Sleep investigation showed: increased sleep efficiency, decreased sleep latency, decreased slow wave sleep latency and increased of sleep spindles in the first hour of sleep. CONCLUSIONS: Research confirms that phototherapy is an effective method of treatment of choice for patients with SAD. The result indicates that phototherapy markedly improved mood and sleep quality.

Adult↗