PubMed Health⌕ Search

Biomedical subjects

Maciej Dancewicz

Publications and source records attributed to Maciej Dancewicz.

10 recordsLinked to original sources
PubMed2006

[Bone marrow isolated micrometastases of non-small cell lung cancer].

UNLABELLED: The ability to detect occult systemic metastases in patients with operable NSCLC could have a significant impact on the management of the disease. The aim of the study was to detect occult micrometastatic tumor cells in bone marrow in patients with resectable NSCLC. MATERIAL AND METHODS: A total of 35 patients (29 men, 6 women), age between 47 and 78 (mean 61.6) were included in the study. In each of the patients bone marrow aspirates from the ribs were sampled during surgery. Both the tumor and the bone marrow aspirate were examined histologically and immunocytochemically with the cytokeratin: AE1/AE3, CAM 5,2, CK-7, CK-18. The presence of grow factors CD 31 and CD 34 were examined as well. RESULTS: No evidence of micrometastases or tumor cells in bone marrow was found in histological examination. Cytokeratin positive (CAM 5,2 +) cells were detected in 33 cases (94.23%) of the tumors and in 21 cases (60.00%) of bone marrow samples. The statistically significant correlation between the presence of CAM 5,2 in tumors and bone marrow was found (p = 0.049). Cytokeratin positive cells were detected in all the 35 tumors (AE1/AE3), in 20 tumors--57.14% (CK-7) and in 23 tumors--65.71% (CK-18). Cytokeratin positive cells (CK-7) were detected in bone marrow sample in one patient only. CONCLUSIONS: Immunocytochemical examination with the use of cytokeratin CAM 5,2 is of use to detect occult micrometastatic tumor cells in bone marrow in NSCLC patients. However, no correlations were found between the presence of cytokeratin CAM 5,2 in bone marrow or tumor and patients' age, sex and the histological type of NSCLC its degree of malignancy and stage.

Aged↗
PubMed2006

[Morgagni's hernia--still a difficult diagnostic problem].

Morgagni's hernia due to its non-specific symptoms and signs along with difficulties to detect it by x-ray imaging is still a disease difficult to diagnose. Patients suffering from this hernia are often treated unsuccessfully because of false diagnosis of other illnesses of the abdomen or thorax. It is only detailed diagnostics that can lead to a proper diagnosis. The authors present the current status of knowledge of Morgagni's hernia, its most common signs and symptoms and available diagnostic and therapeutic methods.

Diagnosis, Differential↗
PubMed2006

[Bacteriological and mycological analysis of material taken from lower respiratory tract in patients with malignancy].

UNLABELLED: The immunosuppression and incorrect function of the natural protection mechanisms are conducive to lower respiratory tract infections. The patients with malignancy, especially with lung cancer, belong to the group at higher risk to develop an infection due to accumulation of numerous risk factors. OBJECTIVE: The aim of this study was to assess the occurrence of bacteria and fungi in materials taken from lower respiratory tract from the patients treated in Thoracic Surgery and Clinical Department of Thoracic Surgery and Tumours from 2000 to 2004. The frequency of occurrence of alert-pathogens was also analyzed. MATERIAL AND METHODS: The retrospective analysis was carried out among 102 positive samples (sputum--68, bronchial secretion--32 and bronchoalveolar lavage--2). The material was obtained from patients treated due to lung cancer (n=84), pulmonary metastases (n=6), primary neoplasms of the chest wall (n=2), lymphoma of the mediastinum (n=3), mesothelioma (n=1) and other malignancies (n=6). The examinations were conducted in compliance with the current procedures, generally accepted in microbiological laboratories. RESULTS: Seventy examined patients (68.63%) had bronchial colonization with bacteria being the potential etiologic agents of lower respiratory tract infections. The presence of yeast-like fungi was confirmed in 62 patients (60.78%). The most frequent strains isolated were: Enterobacteriaceae (40.86%), followed by Staphylococcus aureus (21.51%), Haemophilus influenzae (16.13%) and Streptococcus pneumoniae (7.53%). The nonfermenting gram-negative rods Pseudomonas spp. and Acinetobacter spp. occurred as follows: 6.45% and 3.23%. Among yeast-like fungi the most common species isolated was Candida albicans (63.77%) which occurred more frequently in sputum than in bronchial secretion (p < 0.0004). The strains of Enterobacteriaceae and nonfermenting gram-negative bacillus producing extended-spectrum beta lactamase (ESBL) were not discovered like MBL (metallo- beta lactamase) positive strains. All of the Staphylococcus aureus strains were sensitive to the methicillin. Haemophilus influenzae did not show ampicillin resistance. We observed two strains Streptococcus pneumoniae which were penicillin intermediate but susceptible to the third-generation cephalosporins. CONCLUSIONS: Identification of the potential etiological agents of lower respiratory tract infections can be useful in the rational management of the antibiotics policy in the patients with maliganacy.

Bronchoalveolar Lavage Fluid↗
PubMed2006

[Magnetic resonance imaging in the diagnosis of retrosternal anterior diaphragmatic hernia in an adult man].

The study presents a case report of a retrosternal anterior diaphragmatic hernia in a 46-year-old man presented with abdominal pain, nausea, dyspnoea and treated previously as for chronic pancreatitis. A strong suspicion of the diaphragmatic hernia was generated after chest radiograph. However, the exact diagnosis of the Morgagni hernia was established by magnetic resonance imaging. The hernia was repaired through thoracic incision. The postoperative course proved uneventful: the patient was discharged from the hospital 10 days after surgical intervention.

Diagnosis, Differential↗
PubMed2005

[Procedure in case of exposure of hospital's workers to HBV, HCV and HIV].

The aim of this study was to show our own experiences in the treatment our hospital's workers after the exposition of potentially infectious material. The register of the occupational exposition was established on 1st January 2001. 43 cases of occupational exposition to potentially infectious material were noted down, since the beginning of the observation to 31st October 2004. The persons who were injured, represented different professional groups: 9 physicians, 19 section nurses, 13 operative nurses and 3 maintenance workers. The exposition was caused by needle pricks during blood collection or injections (34 cases), as a result of a scalpel or other surgical instrument cut (2 cases), a splash of infectious material on the skin and conjunctivae (4 cases) and in the singular cases as a result of a bite by a stimulated patient, a medical waste cut in a rubbish bag or the hospital equipment. It was determined in the immunological examinations that among patients being the source of infection were: 1 person HBsAg(+), 5 persons anti-HCV(+), 37 persons HbsAg (-), 33 persons anti-HCV(-) and 5 persons HBsAg(?) and HCV(?). One medical unvaccinated worker was exposed to the HBsAg(+) blood. The specific treatment was administered by the application of 1 dose of anti-HBs immunoglobulin and realization of a series of protective vaccinations against HBV. 4 persons are being observed due to an exposition to HCV(+) blood. In all cases until now the treatment has been finished without a diagnosis of the occupational infection.

Female↗
PubMed2004

[Long-term results after resection of IIIA-N2 non-small cell lung cancer and complementary mediastinal irradiation].

The authors present a retrospective evaluation of long-term results of treatment of patients with IIIA-N2 non-small cell lung cancer (NSCLC), operated and subjected to complementary irradiation of mediastinum in the years 1987-1990. 60 patients were observed: 10 women and 50 men, aged 37-74 years (mean age 56). In all patients a radical resection of lung parenchyma with the primary tumour and mediastinal lymphadenectomy were performed. The one-year survival was 63% (38 patients), three-year survival--15% (9 patients) and five-year survival 13% (8 patients). It was found that the five year-survival in patients with IIIA-N2 NSCLC, in whom a combined therapy was applied (surgery and irradiation), was low, and the most common cause of death in the first three years of follow-up were distant metastases. Moreover it was observed that the number of mediastinal lymph node groups had a great influence on the time of survival.

Adult↗
PubMed2004

[Unsuccessful treatment of pneumothorax which was associated with hilar tumor].

The authors present a case of unsuccessful treatment of pneumothorax which was associated with hilar tumor. A typical underwater-seal system was installed in a 79-year-old patient, but the lung was still collapsed. Because of prolonged air leak, the patient was operated on. During the surgical procedure several bullae in the lung and the inoperable hilar carcinoma were diagnosed. Despite the absence of air leak, the failure of the lung to re-expand was noted postoperatively. However, recurrent air leak, subcutaneous emphysema and respiratory failure caused the patient's death.

Aged↗
PubMed2004

[Fine-needle aspiration biopsy under CT-guidance--usefulness in diagnosis of malignant lung tumors].

UNLABELLED: Aim of the study was to evaluate the usefulness of fine-needle aspiration biopsy (FNAB) in diagnosis of malignant lung tumors. MATERIAL AND METHODS: The results of 438 CT guided FNAB of lung lesions performed between Sep. 1st 1999 and Feb. 20th 2004 were evaluated. RESULTS: In 295 cases (67.35%) the cytological diagnosis of lung tumours were established by FNAB. The most common type of the tumours were: non-small cell lung cancer: 222 (50.69%) and small cell lung cancer: 49 (11.19%). 104 of these results were histologically verified and two false positive results were detected. In 143 cases (32.65%) however, the results established by FNAB were non-diagnostic. 63 of the lesions were verified and in 36 cases (57.1%) the malignant tumours were proved. The specificity of the method regarding malignant lesions reached 93.10%, and its sensitivity for patients with malignancy was 73.91%. The average diameter of the malignant tumour was 5.4+/-1.3 cm whereas in case of non-diagnostic results the diameter of the tumour was 4.1+/-1.6 cm. However, there was no significant difference between the two groups. The most common complication of FNAB was pneumothorax, which occurred in 22 patients (5.02%) and in 13 cases (2.97%) required drainage of the chest cavity. CONCLUSION: FNAB is a safe diagnostic method with high specificity and moderate sensitivity in detecting of malignant lung lesions.

Adult↗
PubMed2003

[Coin lesion in the lung of patients with known malignancy].

Histological examination was performed on 93 pulmonary nodules resected in 90 patients with known malignancy. The diameters of the coin lesions on CT scan were 3-10 mm in 42 cases and 11-30 mm in 51 cases. The most common sources of the previous malignancy were: large bowel (20), breast (14), uterus (12), kidney (11) and larynx (7). In 84 cases the nodules were radically resected through "wedge" resection and in 9 cases lobectomy was performed. Most frequently, coin lesion was caused by metastases of known malignancy (in 69.9%), pulmonary fibrosis (in 11.8%) and by primary lung cancer (in 7.5%). In general, pulmonary nodules were found malignant in 78.5% and benign in 21.5% of the cases. In the subgroup of coin lesions of diameter between 11 and 30 mm malignancy was noted in 94.1%--significantly more frequently than in subgroup of diameter between 3 and 10 mm (59.5%). No significant correlation was found between histological type of pulmonary nodules (malignant or benign) and the type of primary malignancy as well as the time from the treatment of primary malignancy to the detection of the coin lesion.

Adolescent↗