Biomedical subjects

Magdalena Guzowski

Publications and source records attributed to Magdalena Guzowski.

6 recordsLinked to original sources

PubMed2005

Primary orbital Ewing sarcoma in a middle-aged man.

A 54-year-old man presented with a painful left proptosis and a soft tissue mass at the inferolateral aspect of the left orbit with bone involvement. There was no clinical or investigational evidence of systemic disease. Both light microscopy and immunohistochemistry were required for the diagnosis of Ewing sarcoma. After failure of chemotherapy alone, management included extensive surgical excision and postoperative adjuvant radiotherapy and chemotherapy. Despite intervention, the patient died of widespread metastatic disease 17 months after initial presentation. Although rare, Ewing sarcoma should be included in the differential diagnosis of uniform round cell orbital tumors in adults.

Biopsy↗

PubMed2003

Asymmetric refraction in an older population: the Blue Mountains Eye Study.

PURPOSE: To describe prevalence and associations of asymmetric refraction in an older population. METHODS: All participants in the Blue Mountains Eye Study had comprehensive eye examinations, including refraction. Spherical equivalent (SEq = sum sphere +.5 cylinder), in diopters, defined refractive error. Refractive asymmetry was assessed in phakic participants; anisometropia was defined as > or =1.0 diopters SEq difference between eyes. RESULTS: Anisometropia was present in 14.7% of participants. Mean refractive asymmetry (in diopters) in persons aged <60 years was 0.43; 60 to 69 years, 0.51; 70 to 79 years, 0.72; and 80+ years, 0.88. Prevalence and severity of anisometropia increased with age (P <.001), increasing ametropia or astigmatism. Associations included older age, cataract, and increasing ametropia. Myopic participants >-3.0 diopters had the highest anisometropia prevalence. CONCLUSIONS: Refractive asymmetry was associated with age, increasing ametropia, and cataract.

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PubMed2003

Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study.

PURPOSE: To describe the 5-year cumulative incidence and change in epiretinal membranes in a defined older Australian population. DESIGN: Population-based cohort study. PARTICIPANTS: Three thousand six hundred fifty-four persons 49 years of age or older, living in the Blue Mountains area, west of Sydney, Australia, participated in the baseline survey during 1992 to 1994. The cohort was reexamined after 5 years in 1997 to 1999. Excluding persons (543) who died since the baseline, 75% of survivors (n = 2335) attended the follow-up examination. METHODS: All participants underwent a detailed eye examination, including stereo retinal photography. Epiretinal membranes were diagnosed from grading of baseline and 5-year retinal photographs. MAIN OUTCOME MEASURES: Epiretinal membranes were classified as either preretinal macular fibrosis (PMF), with retinal folds, or as a less severe form, termed cellophane macular reflex (CMR), without retinal folds. The incidence of epiretinal membranes was determined if either lesion was found in eyes with no preexisting epiretinal membrane at baseline. Progression was defined if the area of involvement increased by more than 25%, regression if it decreased by more than 25%, and stable if it changed by less than 25%. RESULTS: Epiretinal membranes developed in the first eye of 108 of 2030 participants who had no sign of this condition in either eye at baseline, 5.3%, 95% confidence interval (CI) 4.4 to 6.4. Five-year cumulative incidence rates for PMF and CMR were 1.5% and 3.8%, respectively. Of those participants with epiretinal membranes in one eye at baseline, 18 of 133 (13.5%) developed this sign in their second eye after 5 years. New epiretinal membranes (mostly CMR) occurred in 15 of 165 subjects (9.1%; CI, 5.2-14.6) who had undergone cataract surgery since the Blue Mountains Eye Study I. This rate was significantly higher than in the nonsurgical group, 92 of 1861 (4.9%; CI, 4.0-6.0) of whom developed epiretinal membranes. Progression from CMR to PMF was observed in 17 of 183 eyes (9.3%). Existing epiretinal membranes progressed, regressed, or remained stable in 28.6%, 25.7%, and 38.8% of eyes, respectively. CONCLUSIONS: This study has documented the 5-year cumulative incidence and the natural history of epiretinal membranes in an older population.

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PubMed2003

Five-year refractive changes in an older population: the Blue Mountains Eye Study.

PURPOSE: To examine 5-year changes in refractive error and astigmatism in an older population. DESIGN: Population-based cohort study. PARTICIPANTS: The Blue Mountains Eye Study examined 3654 residents aged 49 years or older from 1992 to 1994. After excluding 543 persons who died since baseline, 2335 (75.1%) attended 5-year examinations from 1997 to 1999. METHODS: Both examinations included a detailed eye assessment, with subjective refraction performed according to a modified Early Treatment of Diabetic Retinopathy Study protocol. MAIN OUTCOME MEASURES: Spherical equivalent (sum of sphere + cylinder) was used as the measure of refractive error. Only phakic eyes with best-corrected visual acuity >20/40 were included (n = 3701). RESULTS: Similar changes in refractive error were observed for the two eyes. Symmetric changes were found in 72% of participants when the difference between eyes was within 0.5 diopters (D) and in 91% when the difference was within 1.0 D. The 5-year change in spherical power was in a hyperopic direction for younger age groups and in a myopic direction for older subjects, P < 0.0001. The gender-adjusted mean change in refractive error in right eyes of persons aged 49 to 54, 55 to 64, 65 to 74, and 75 years or older at baseline was +0.41 D, +0.30 D, +0.05 D, and -0.22D, respectively. Refractive change was strongly related to baseline nuclear cataract severity; grades 4 to 5 were associated with a myopic shift (-0.33 D, P < 0.0001). Education level and age of onset of myopia, but not gender or diabetes, also predicted refractive change. The mean age-adjusted change in refraction was +0.14 D for hyperopic eyes, +0.32 D for emmetropic eyes, and +0.15 D for myopic eyes. The mean change in cylinder power over the 5-year period was small, irrespective of baseline refraction. The axis of astigmatism remained stable in most cases (64%), whereas 12% changed to "against the rule" and 11% to "with the rule." CONCLUSIONS: This report has documented refractive error changes in an older population and confirmed reported trends of a hyperopic shift before age 65 years and a myopic shift thereafter associated with the development of nuclear cataract.

Age Distribution↗

PubMed2002

Acute haptic-induced pigmentary glaucoma with an AcrySof intraocular lens.

A 49-year-old man had uneventful endocapsular phacoemulsification with in-the-bag implantation of an AcrySof SA60AT single-piece intraocular lens (IOL) (Alcon) in the right eye. Twenty-seven days postoperatively, he presented with ocular pain, intraocular pressure of 48 mm Hg, 360 degrees of hyperpigmentation of the trabecular meshwork, and iris pigment epithelial atrophy in the region of the upper temporal haptic, which had dislocated into the sulcus. The patient made an excellent recovery following IOL removal and exchange. Scanning electron microscopy of the explanted IOL demonstrated that the haptic had a rough lateral surface and anterolateral edge. We do not think this IOL should be implanted in the sulcus placement of the heptics. In this article, we report the case of a patient with an AcrySof SA60ATIOL (Alcon) who developed acute pigmentary glaucoma when the inferior haptic slipped out of the bag and came into contact with the pigmented iris and ciliary body.

Acrylic Resins↗

PubMed2002

Refractive changes following cataract surgery: the Blue Mountains Eye Study.

This study aimed to assess refractive changes following cataract surgery in subjects attending the Blue Mountains Eye Study baseline examinations in 1992-1994 (3654 residents aged 49+ years),with 2335 (75.1%) survivors re-examined after 5 years. Participants underwent a standardized subjective refraction. History of cataract surgery was confirmed at examination and lens photograph grading. During follow up, 151 persons had cataract surgery (60 bilateral, 91 unilateral). After exclusions, data from 198 eyes(93 right, 105 left) were analysed. The proportions of eyes achieving postoperative spherical equivalent refraction (SER) -0.25 to +0.25 D, -0.50 to +0.50 D, -0.75 to +0.75 D and -1.00 to +1.00 D,were 32%, 44%, 60% and 74%,respectively. The magnitude and direction of refractive changes following cataract surgery were related to the preoperative refraction. Myopic eyes had a hyperopic shift (mean +2.76 D),hyperopic eyes a myopic shift (mean -1.77 D) and emmetropic eyes recorded little change (mean -0.13 D). Astigmatism (> or = 1.00 D cylinder) increased slightly postoperatively, from 47% to 56%, mostly 'against the rule' but with less oblique astigmatism. These findings indicate satisfactory refractive outcomes following current cataract surgery in a random older population.

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