Cytotherapy as a novel treatment for retinopathy of prematurity - a hypothesis.
Explore the source record for details and available documents.
Cord Blood Stem Cell Transplantation↗
Biomedical subjects
Majid Farvardin
Publications and source records attributed to Majid Farvardin.
LASIK after retinal detachment surgery.
PURPOSE: To compare, in the same individuals, the safety and efficacy of laser in situ keratomileusis (LASIK) in eyes with and without previous retinal detachment surgery. METHODS: In a prospective clinical trial, seven myopic patients who had previously undergone scleral buckling surgery in one eye underwent conventional LASIK surgery in both eyes. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refraction, Orbscan topography and pachymetry were recorded before and 1, 3, 6 and 12 months after surgery. The eyes were divided into two groups: group 1 consisted of eyes that had undergone previous surgery for retinal detachment, and group 2 consisted of the fellow eyes of the same patients, which had not undergone any previous ocular surgery. Student's t-test for match-paired data was used to evaluate the significance of differences. RESULTS: LASIK was performed successfully in all patients. The UCVA improved in all eyes in both groups. The mean change in the spherical equivalent between 1 and 12 months after LASIK surgery was 1.7 +/- 1.1 and 0.6 +/- 0.5 diopter in groups 1 and 2, respectively (p = 0.019). CONCLUSION: LASIK may be considered for treatment of myopia in eyes that have had previous surgery for retinal detachment. However, the risk of regression may be higher in such eyes than in eyes with no previous scleral buckling surgery.
Adult↗
Anterior transposition of the inferior oblique muscle for treatment of superior oblique palsy.
PURPOSE: Weakening of the inferior oblique muscle is the procedure of primary importance in patients with superior oblique palsy, Knapp's Classes I and III. In this study, the effectiveness of anterior transposition of the inferior oblique muscle in treatment of these patients was evaluated. METHODS: Sixteen patients with superior oblique palsy, Knapp's Classes I and III, underwent anterior transposition of the inferior oblique muscle. The tip of the disinserted muscle was sutured to the sclera, parallel, and adjacent to the lateral border of the inferior rectus muscle insertion. The prism and alternate cover test measurements were made in all cardinal positions of gaze before and 6 months after surgery. RESULTS: The mean reduction of hyperdeviation was 15 prism diopters (PD) in the primary position, 23.4 PD in adduction, 26.65 PD in elevation and adduction, and 18.63 PD in depression and adduction. There was no hypotropia in the primary position. Mild limitation of upgaze has occurred in 3 of these patients, and mild fullness of the lower lid was developed by 25%. Postoperative hyperdeviation in the primary position was 5 PD or less in 15 out of 16 patients. CONCLUSIONS: The anterior transposition of the inferior oblique muscle is very effective in eliminating hyperdeviation in patients with superior oblique palsy, Knapp's Classes I and III. Up to 25 PD reduction of hyperdeviation in the primary position can be achieved. If this type of anterior transposition is used, primary position hypotropia or marked limitation of upgaze possibly will not occur.
Adolescent↗
Combined resection and anterior transposition of the inferior oblique muscle for the treatment of moderate to large dissociated vertical deviation associated with inferior oblique muscle overaction.
PURPOSE: To evaluate the efficacy of combined resection and anterior transposition of the inferior oblique muscle for the treatment of eyes with a moderate to large amount of dissociated vertical deviation (DVD; 10 or more PD) associated with overaction of the inferior oblique muscle. PATIENTS AND METHODS: Surgery was performed on 15 eyes of 9 patients with moderate to large DVD associated with overaction of the inferior oblique muscle. The inferior oblique muscle was disinserted from the sclera and 4 mm of its distal end was resected. It was transposed to a position 1 mm anterior to the lateral border of the inferior rectus muscle insertion. The prism under cover test was used to measure the DVD. Overaction of the inferior oblique muscle was graded on a 4-point scale of 1+ to 4+. The surgical results were evaluated at 1 month and 1 year after surgery. RESULTS: Preoperatively, the mean DVD measured 16.6 PD. It had decreased to 1.3 PD 1 month after the operation and to 2.6 PD 1 year after the operation. Before the operation, 5 eyes had 4+ and 10 eyes had 3+ inferior oblique muscle overaction. One year after the operation, only 3 eyes had 1+ inferior oblique muscle overaction. None of the patients developed diplopia or hypotropia in the primary position. Mild limitation of elevation has been noticed in 20% of the eyes. CONCLUSION: Combined resection and anterior transposition of the inferior oblique muscle is an effective treatment for moderate to large DVD associated with overaction of the inferior oblique muscle.
Adolescent↗