Biomedical subjects

Manabu Sasahara

Publications and source records attributed to Manabu Sasahara.

5 recordsLinked to original sources

PubMed2006

Pigment epithelial detachment in polypoidal choroidal vasculopathy.

PURPOSE: To study the morphological features of serosanguineous pigment epithelial detachments (PEDs) with accompanying polypoidal lesions in eyes with polypoidal choroidal vasculopathy (PCV). DESIGN: Retrospective observational case series. METHODS: For this observational case study, we retrospectively reviewed 93 consecutive eyes of 85 patients with PCV. The lesions in eyes with PCV were examined with indocyanine green angiography (IA) and optical coherence tomography (OCT). RESULTS: Of 93 eyes with PCV, 51 eyes (55%) had serous or hemorrhagic PEDs. Of these 51 eyes, a notch in the PED was found in 27 eyes (53%) by angiography, most of which showed polypoidal lesions by IA that corresponded in location to the notch observed by angiography. Polypoidal lesions were detected outside the PED in one eye (2%), at the margin of the PED in 33 eyes (65%), and inside the PED in 12 eyes (24%). OCT revealed that PED had a notch observed tomographically in 29 eyes (57%), most of which corresponded in location to polypoidal lesions seen by IA. In eight eyes, polypoidal lesions, which were adherent to the inner surface of the serous PED, appeared to be detached from the Bruch membrane and the choroid. CONCLUSIONS: Polypoidal lesions are located at the margin of PED and make a notch in the accompanying PED that is visible by angiography and tomographically. When the polypoidal lesions have increased exudate, the fluid from the lesions infiltrates under the polypoidal lesions themselves, which results in the lesions detaching from the Bruch membrane and appearing to be located inside the PED.

Aged↗

PubMed2006

Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability.

PURPOSE: To describe the incidence and clinical characteristics of polypoidal choroidal vasculopathy (PCV) associated with choroidal vascular hyperpermeability. DESIGN: Retrospective observational case series. METHODS: We reviewed the medical records of 122 consecutive eyes with PCV and 106 consecutive eyes with exudative age-related macular degeneration (AMD). Fluorescein angiography and indocyanine green (ICG) angiography were performed using a confocal scanning laser system. In the midphase of ICG angiography, we evaluated choroidal vascular hyperpermeability, which is recognized as one of the characteristic findings in central serous chorioretinopathy (CSC). Choroidal vascular hyperpermeability appeared as multifocal patchy areas of hyperfluorescence with blurred margins within the choroid that increased in intensity with time after injection of the dye. RESULTS: Of 122 eyes with PCV, 12 (9.8%) eyes of 10 patients exhibited multifocal choroidal hyperfluorescence in the midphase of ICG angiography, whereas two (1.9%) of 106 eyes with exudative AMD showed a similar appearance (P = .013). Of the 12 eyes in 10 patients with PCV that demonstrated multifocal choroidal hyperfluorescence, we also noted that the early phase of ICG angiography showed choroidal filling delay in seven eyes (58%) and venous dilation in 12 eyes (100%). Four of these 12 eyes (33%) had a medical history of CSC, and nine (90%) of the 10 patients revealed multifocal choroidal hyperfluorescence bilaterally. CONCLUSIONS: Multifocal choroidal hyperfluorescence seen by ICG angiography occurs more frequently in eyes with PCV than in those with AMD. Choroidal vascular hyperpermeability, reportedly a characteristic finding in CSC, might be one of the risk factors of PCV.

Aged↗

PubMed2006

[Visual prognosis of branch retinal vein occlusion with macular edema].

PURPOSE: To evaluate visual outcome and prognostic factors of branch retinal vein occlusion (BRVO) combined with macular edema, when no aggressive treatment is performed. PATIENTS AND METHODS: We retrospectively analyzed 80 eyes of 80 patients of BRVO associated with macular edema. The average age was 65.7 years and the average follow-up period was 32.1 months. Oral or instillation drug therapy was conducted in 42 eyes and peripheral scatter argon laser photocoagulation for the capillary non-perfusion area was carried out in 61 eyes (photocoagulation for macula was excluded). RESULTS: Baseline visual acuity(BVA) and final visual acuity(FVA) had a positive correlation (r= 0.60, p< 0.001). 69% of eyes with BVA of 0.1 or less remained at FVA 0.1 or worse, while 78% of eyes with BVA of 0.8 or better maintained FVA of 0.8 or better. Visual acuity improved in 26%, remained unchanged in 54%, and deteriorated in 20% during follow-up periods. In the eyes with visual loss the deterioration occurred in the early periode from onset, but in the eyes with visual improvement the visual acuity tended to improve steadily. CONCLUSIONS: Even if macular edema occurs, some of the BRVO eyes can attain good visual acuity. However, we recommend aggressive treatment when the best-corrected acuity is poor or when the visual acuity worsens gradually, because there is a strong possibility that the visual prognosis will be poor.

Adult↗

PubMed2005

Endoscope-assisted transscleral suture fixation to reduce the incidence of intraocular lens dislocation.

PURPOSE: To examine the surgical complications of transscleral sulcus suture of posterior chamber intraocular lenses (IOLs) and to compare the rates of surgical complications between patients in the nonendoscope-assisted and endoscope-assisted groups. SETTING: Kyoto University Hospital, Kyoto, Japan. METHODS: This retrospective nonrandomized study comprised 121 eyes of 115 patients who had transscleral sulcus suture fixation of an IOL by the ab externo method. Typical 3-port vitrectomy was performed in 26 eyes in which the needle entry site and the haptic location were controlled using an endoscope. RESULTS: During follow-up of at least 3 months, surgical complications in the nonendoscope-assisted group (95 eyes) included IOL dislocation in 22 eyes (23%), high astigmatism in 12 eyes (13%), transient ocular hypertension in 10 eyes (11%), vitreous hemorrhage in 5 eyes (5.3%), retinal detachment in 4 eyes (4.2%), and cystoid macular edema in 2 eyes (2.0%). In the endoscope-assisted group (26 eyes), the same complications were markedly decreased: there were no cases of IOL dislocation, high astigmatism, vitreous hemorrhage, retinal detachment, or cystoid macular edema; transient ocular hypertension occurred in 1 eye (3.8%). There was a statistically significant difference in the incidence of IOL dislocation between the 2 groups (P<.01). CONCLUSION: Using an endoscope for transscleral sulcus suturing of an IOL can be an effective technique to reduce surgical complications, especially postoperative IOL dislocation.

Adult↗

PubMed2003

Optical coherence tomographic observations before and after macular hole formation secondary to laser injury.

PURPOSE: To describe the ophthalmoscopic and optical coherence tomographically determined retinovitreous interface before and after the development of a macular hole secondary to an accidental laser injury. DESIGN: Observational case report. METHODS: Ophthalmoscopic and optical coherence tomography (OCT) findings in a 53-year-old man were evaluated before and after the macular hole formation secondary to a laser injury. Visual function was followed for 9 months after surgery. RESULTS: A 53-year-old man sustained injury to his right eye by a Ti: Sapphire laser. On the following day, his corrected visual acuity was 0.3, and a small pigment epithelial atrophy was present in the right foveal area. No macular hole was detected by OCT and the retinovitreal interface was normal. Fifty-three days later, a full-thickness macular hole appeared, and no posterior vitreous detachment was detected by OCT. The hole was closed by surgery with final best-corrected visual acuity of 0.7. CONCLUSIONS: Macular holes can develop without visible traction on the retina and can occur long after retinal injury.

Eye Injuries↗