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Biomedical subjects

Manfred Wolfersdorf

Publications and source records attributed to Manfred Wolfersdorf.

At least 19 recordsLinked to original sources
PubMed2006

Determination of glucuronidated 5-hydroxytryptophol (GTOL), a marker of recent alcohol intake, by ELISA technique.

OBJECTIVES: To compare markers of alcohol consumption. DESIGN AND METHODS: Measurement of urinary ethyl glucuronide, 5-hydroxytryptophol, 5-hydroxytryptophol glucuronide, 5-hydroxyindole acetic acid in 10 patients during alcohol withdrawal. RESULTS: 5-Hydroxytryptophol glucuronide was measured by ELISA with good analytical precision, its diagnostic specificity and sensitivity was better than that of 5-hydroxytryptophol and its correlation was closer to ethyl glucuronide than to 5-hydroxytryptophol. CONCLUSION: Determination of 5-hydroxytryptophol glucuronide by ELISA offers promising results in detection of previous alcohol consumption.

Adult↗
PubMed2005

[Increasing prevalence of amphetamine--and methamphetamine-induced psychosis].

OBJECTIVE: With changed consumer behaviour in the drug scene the psychiatric complications with the derivates of amphetamine increase. In some regions methamphetamin is particularly common. Flashbacks, which can be triggered by psychosocial stress, as well as the age of the usually young patients lead to the differential diagnosis of schizophrenia. METHODS: During the observation period 1998 - 2000 the diagnostic distributions and the psychosocial base data of all patients admitted to the BKH Bayreuth with the clinical picture of a paranoid psychosis, were examined regarding an increase of drug-induced psychosis. RESULTS: Both the number of the treated patients with chronic dependence on methamphetamine as well as acute admissions of patients with drug-induced psychosis increased. Differences to patients diagnosed a schizophrenia could be shown. CONCLUSION: With the further increasing abuse of stimulants like methamphetamine the number of patients with induced psychosis will escalate. Specific settings for treatment will be required to address the addiction as well as the psychosis.

Amphetamine↗
PubMed2005

Suicidality, bipolar disorders, and pharmacotherapy.

Although the existence of mood disorders was identified centuries ago, the present state of knowledge is unsatisfactory. This special issue of Archives of Suicide Research (ASR), the official journal of the International Academy for Suicide Research, presents the state of the science and collects new empirical data. Different aspects of suicidality in bipolar and bipolar spectrum disorders are outlined and the prophylactic aspects of pharmacotherapy are noted, especially the anti-suicide effect of lithium. A call for further study is, however, necessary.

Antimanic Agents↗
PubMed2005

Bipolar affective disorders and suicide during psychiatric in-patient treatment.

On the basis of the known literature and our own results on patients' suicide, reflections are made with regard to the group of suicide cases with bipolar affective illnesses that commit suicide during inpatient psychiatric treatment. In our own studies, we diagnosed mania in as many as 8% of all suicide cases. Risk factors for suicidal behavior in bipolar affective disorder are discussed, especially in terms of psychopathology, and the social consequences of the disease are discussed.

Bipolar Disorder↗
PubMed2005

Adherence to guidelines for treatment of depression in in-patients.

BACKGROUND: Adherence to treatment guidelines enhances treatment outcome. However, in clinical practice many patients with depression do not receive appropriate treatment. AIMS: To evaluate the treatment of depression in in-patients of German psychiatric hospitals with respect to treatment outcome and adherence to guidelines. METHOD: We recruited 1202 in-patients with depression from ten different hospitals. Quality data concerning treatment were collected at admission, during the treatment course and at discharge. RESULTS: The level of depression was significantly decreased and most patients were satisfied with treatment. Many aspects of the treatment routine adhered to guideline recommendations. Adherence to guidelines could be improved with respect to adjustment of antidepressant dosage, reduction of benzodiazepine prescription, enhanced use of electroconvulsive therapy and wider use of interpersonal therapy. CONCLUSIONS: The study reveals a high standard of psychiatric treatment of in-patients with depression. Nevertheless there is still room for improvement. Differences between hospitals in adherence to guidelines indicates the need for individual application of quality management tools.

Adult↗
PubMed2004

[Quality of care in internal medicine in German psychiatric hospitals].

OBJECTIVE: Study on selected aspects of structural quality of care in internal medicine in German psychiatric hospitals. METHOD: Investigation by questionnaire completed by medical directors of German psychiatric hospitals (response quote 48.8 %). RESULTS: Descriptive data from 81 hospitals with 25 920 inpatient beds are presented relating to various indicators of structural quality of care in internal medicine (e. g. availability of internal medicine consultations, diagnostic equipment, as ECG, clinical chemistry laboratory, ultrasound). CONCLUSIONS: We found evidence of a satisfactory infrastructure relating to internal medicine in a majority of hospitals. However, there exist also indications of significant deficits pertaining to certain aspects of medical care in the institutions investigated. With regard to the importance of medical comorbidity in clinical psychiatry the availability of adequate resources in internal medicine is a relevant indicator of quality of care in psychiatric hospitals.

Comorbidity↗
PubMed2004

[Psychotherapy units in Bavarian state mental hospitals].

OBJECTIVE AND METHOD: In this paper we report about the situation of psychotherapeutic inpatient treatment in Bavarian state mental hospitals, based on data coming from surveys in those hospitals. RESULTS AND CONCLUSION: 22 State mental hospitals in Bavaria have 1217 beds for acute psychotherapy, proofed on the basis of quality criteria. More than 50 per cent of all psychotherapy beds are located in those hospitals.

Germany↗
PubMed2004

[Long-term psychosocial outcome of young adult inpatients after a first manifestation of "neurotic" symptoms].

OBJECTIVE: It is often assumed that there is a predictive relationship between the onset of psychiatric disorder in young adulthood and the severity of their course. Because the significance is rather contradictive and poorly backed by empirical data, we have investigated this issue by a catamnestic approach. METHOD: From 96 inpatients aged between 18 to 25 years with a first manifestation of a "psychogenetic" disorder 54 % were studied 8.6 +/- 1.5 year later. RESULT: In general there was a positive development as well psychopathological as social, although complete normalisation was not reached. CONCLUSIONS: This result is almost identical with catamnestic findings with comparative studies on older patients . Our findings do not support the concept of negative predictive value of first manifestation of psychogenetic disorder in early adulthood.

Adolescent↗
PubMed2004

[The development of utilisation of psychoneurotic in-patients in hospitals for psychiatry and psychotherapy of the so-called "new" Federal States of Germany].

OBJECTIVE: Up to now psychotherapeutic treatment naturally is part of treatment strategies of mental hospitals and departments of psychiatry at general hospitals. Actually there is a controversial debate in this issue. The aim of this study was to evaluate the development of the utilization of these hospitals by patients with "psychogenic disorders" in the new federal states of eastern Germany. METHOD: We studied the changes in the utilization in hospitals of psychiatry and psychotherapy in Thuringia 1993 up to 1999 by patients with ICD-9-diagnoses 300 - 1 and 306 - 9 and compared these data with these of other clinics in East und West Germany. RESULT: The utilization of psychotherapy patients increased in all hospitals. The increase in Thuringia was highest, in the other eastern German it was higher as in western clinics. Reasons of admissions for in-patient psychotherapeutic treatment were suicide ideations and attempts, aggression against others and prepsychotic agitation. CONCLUSIONS: These results can be seen as a sign of a similar necessity of this care in the eastern as in western population under similar psychosocial conditions.

Acute Disease↗
PubMed2004

[Unit for psychotherapy at the clinic for psychiatry and psychotherapy Bayreuth].

OBJECTIVE AND METHOD: Inpatients of "psychotherapeutic treatment units" at State Mental Hospitals in Bavaria are different from those treated in so-called psychosomatic clinics for rehabilitation, looking at additional criteria like psychiatric and somatic comorbidity or suicidal behaviour. RESULTS AND CONCLUSION: Treatment concepts and results are respectable and comparable to so-called psychosomatic clinic. In this paper we describe the "Psychotherapy Unit" at the Clinic for Psychiatry and Psychotherapy Bayreuth. Depressive episode is the most diagnosis, with 1 to 4 comorbid psychiatric diagnosis in 82 % of all patients and 28 % with somatic comorbidity.

Adult↗
PubMed2004

[Death by illegal drugs in Bavaria 1990 up to 2002].

OBJECTIVE AND METHOD: In our paper we report about drug mortality in Bavaria in the years 1990 up to 2002, using statistical trend tests (Spearman rho, Kendall tau). RESULTS: We observed an increase of deaths by illegal drugs in Bavaria as whole, on the other hand also decreases in different parts of the country.

Cause of Death↗
PubMed2003

[In-patient suicide -- a comparison of psychiatric in-patient suicides versus a control group of inpatients from the same treatment era without suicide].

In our study we compare n = 64 in-patient suicides with a group of non-suicide in-patients which received psychiatric treatment during the same period. The matched patient was the next admitted patient. We found a significantly higher portion of schizophrenic and depressed patients in the suicide group, whereas suicides showed more depressive symptoms, more suicidal ideations before the suicide and more subjective suffering. Suicides received more psychopharmaca.

Adolescent↗
PubMed2003

[Casuistry of a Long Duration Depressive Adjustment Disorder]

Stressing live events can lead to serious deficits of emotional and social function and decrease in vitality. Depressive mood, anxiety and a considerable reduction in the mastering of daily live activities are symptoms of these disorders. Social medical and economical consequences can be reduced by early diagnosis of left performance and psychotherapeutic interventions. The example of a 41 year old man with adjustment disorder after an embolic brain injury shows how diagnosis of performance, and special psychotherapeutic treatment allowed the reintegration on the labour market.

Journal Article↗