Biomedical subjects

Manuel Rosety

Publications and source records attributed to Manuel Rosety.

3 recordsLinked to original sources

PubMed2006

[Influence of regular exercise on erythrocyte catalase activity in adolescents with Down syndrome].

BACKGROUND AND OBJECTIVE: Individuals with Down syndrome have been generally described as having high levels of oxidative stress. In order to improve their redox metabolism, the present study was undertaken to ascertain the influence of regular exercise in erythrocyte catalase activity in this population. SUBJECTS AND METHOD: 31 male adolescents with Down syndrome--mean age (standard deviation): 16.1 (1.1) years--performed a 12-week training program with 3 days/week, consisting of warm up (15 min), followed by a main part (20-35 min) at a work intensity of 60-75% of peak heart rate (HRmax = 194.5 - [0.56 age]) and by a cool-down period (10 min). 7 adolescents with trisomy 21 age, sex and body mass index-matched were used as controls. Beutler's method was used to determine catalase activity in the supernatant of erythrocyte hemolysates. RESULTS: When compared to baseline values, catalase activity was not increased significantly--1,607.0 (231) U/gHb vs 1,663.2 (280) U/gHb; (p = 0.151)- after a 12-week training program. No significant differences were found in controls. CONCLUSIONS: Regular exercise did not increase significantly catalase activity. Further studies are required in order to highlight potential benefits of regular exercise in redox metabolism of Down syndrome individuals.

Adolescent↗

PubMed2006

Influence of 12-week exercise training on fat mass percentage in adolescents with Down syndrome.

BACKGROUND: Current findings suggest that more attention needs to be given to the increase in body mass achieved by disabled populations, especially by individuals with mental retardation, to minimize long-term negative health consequences. Accordingly, it would be of interest to design adequate strategies based on physical activities that may be easily performed to ensure adherence as a healthy lifestyle choice for these populations. MATERIAL/METHODS: To attain this goal, 22 male adolescents with Down's syndrome (mean age: 16.2 +/- 1.0 years) underwent a 12-week physical exercise intervention consisting of three sessions of one hour per week in both water and on land for 12 weeks. Fat mass percentage was calculated from anthropometric measurements according to the Durnin-Womersley equation. A paired t test was performed to evaluate possible differences in antropometrical characteristics between before and after the physical exercise intervention. RESULTS: According to the body mass index, it was observed that 31.8% of the studied individuals presented overweight and 27.3% of them were obese before starting our experiment. The mean value of the percentage of fat mass was reduced significantly, from 31.8 +/- 3.7% to 26 +/- 2.3%, at the end of the study (p = 0.021). CONCLUSIONS: We may conclude that the adolescents with Down's syndrome were able to reduce their fat mass percentage significantly when performing a 12-week training program, which could have important impact on the comorbidity associated with obesity and on the quality of life of this population.

Adolescent↗

PubMed2005

[A 12-week physical activity program increases glucose-6-phosphate-dehydrogenase activity in Down syndrome adolescents].

In recent years it has been claimed that trisomic cells are more sensitive to oxidative stress since there is an imbalance in the hydrogen peroxide metabolism. We designed the present study to assess the activity level of antioxidant enzyme glucose-6-phosphate-dehydrogenase (G6PDH) of erythrocytes in 31 male adolescents with Down syndrome (mean age 16.3 +/- 1.1) after performing a 12 week aerobic training program. First of all, a significant increase of 14.9% in the catalytic activity of G6PDH was observed in male adolescents with Down syndrome when compared with age, sex and body mass-matched controls without trisomy. After 12-wk program its activity increased significantly compared to baseline value in Down syndrome individuals. Our data are consistent with previous evidence of the existence of higher oxidative stress in adolescents with Down syndrome when compared to the general population. We may also conclude that G6PDH activity was significantly increased after a 12 week exercise program.

Adolescent↗