Biomedical subjects

Manuel Vallecillo-Capilla

Publications and source records attributed to Manuel Vallecillo-Capilla.

4 recordsLinked to original sources

PubMed2003

Phagocytosis and allogeneic T cell stimulation by cultured human osteoblast-like cells.

BACKGROUND/AIMS: The antigen phenotype of human osteoblast-like cells suggests that they are related to other cellular populations and may also have immunologic functions in common. METHODS: Flow cytometry and transmission electron microscopy were used to show the phagocytotic activity of osteoblast-like cells in culture. The allogeneic stimulation of T cells by human osteoblast-like cells was determined by the measurement of T cell proliferation. RESULTS: We demonstrated in vitro that human osteoblast-like cells isolated from normal bone specimens obtained during mandibular osteotomy can phagocytose particles of different nature and size and can stimulate allogeneic T cells. Phagocytosis of microorganisms (E.coli, Klebsiella or C. albicans) was observed, although at a very low rate of activity in comparison with the phagocytosis of latex particles. CONCLUSION: Our results suggest that human osteoblast-like cells may perform immunologic functions and act as antigen presentation cells.

Antigen-Presenting Cells↗

PubMedDate not supplied

Juvenile ossifying fibroma: a case study.

We present the case of an 8-year-old patient with a juvenile ossifying fibroma in the right mandibular angle and a radicular cyst in the left mandibular angle, which produced a major swelling at the level of the mandibular angles and prevented the correct eruption of the lower first molars. After the clinical and radiological (panoramic X-ray and dental scan of the mandible), the corresponding surgical treatment (cystectomy and remodelling) and histopathological study were carried out. Although juvenile ossifying fibroma is an uncommon clinical entity, its aggressive local behaviour and high recurrence rate mean that it is important to make an early diagnosis, apply the appropriate treatment and, especially, follow the patient up over the long term.

Child↗

PubMedDate not supplied

Post graduate training in oral surgery in Spain.

The objective of this investigative study is to provide information on the type of public postgraduate training in oral surgery currently being taught in Spain. A descriptive study is made relating to the theoretical and practical syllabuses of the different Masters, through questionnaires answered by students who had previously completed the postgraduate course. Later, a possible relationship between age, sex and previous training in dentistry or stomatology was explored. The results show a poorer preparation in subjects related to the planning and carrying out of treatment of salivary gland pathologies, transposition of the inferior alveolar nerve, treatment of oral tumors, and the treatment planning for osteitis and osteomyelitis. There is a difference between the sexes in a number of answers, where females give higher scores. The stomatologist scores higher in treatment planning for complicated extractions and in the carrying out of dental transplants. It seems that the older the student, the less prepared they are to carry out a treatment plan which includes a biopsy, and the better prepared they are to treat dental emergencies, dentoalveolar trauma, osteitis and osteomyelitis. We can conclude principally that the students give a generally positive evaluation of the oral surgical training, both theoretical and practical, except in the more complex topic areas which appear to relate to the maxillofacial surgeons.

Adult↗

PubMedDate not supplied

A pilot study in the development of indices for predicting the clinical outcome of oral bone grafts.

PURPOSE: Bone grafting to repair osseous defects is widely used in dentistry, but little information on how to predict the clinical survival of grafted bone is currently available. As an initial step toward the establishment of formal criteria for predicting the clinical outcome of oral bone grafts, this pilot study sought to determine the relevance of adverse clinical and radiographic parameters as predictor variables for graft survival. MATERIALS AND METHODS: Eighty patients presenting with a variety of clinical conditions were treated with 83 oral bone grafts. Alloplastic, allogenic, and/or autogenous materials were used with or without barrier membranes. During follow-up appointments at 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years after grafting, a series of clinical and radiographic parameters were used to evaluate the degree of graft integration. The data were then analyzed to determine the prediction accuracy of each variable in relation to the results of the graft. RESULTS: The findings of this clinical study suggest that the variables of (1) graft type, (2) inflammation, (3) infection, (4) fistula, (5) graft exposure, (6) pain, and (7) radiolucency were good indices for predicting graft survival, especially with cumulative data. DISCUSSION: The quality of the prognostic indices appeared to be good and should be further investigated for future applications. CONCLUSIONS: The cumulative index, with a sensitivity of 88.9% and a specificity of 93.8%, was the best predictor of clinical outcome. The 1-month and 3-month indices were similar.

Adolescent↗