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María Jones-Caballero

Publications and source records attributed to María Jones-Caballero.

5 recordsLinked to original sources
PubMed2005

[Consensus document on phototherapy: PUVA therapy and narrow-band UVB therapy].

It is essential to develop a consensus document on phototherapy in order to adapt this procedure to the specific characteristics, needs and reality of our milieu. Using a review of existing literature on the subject and the experience of its own members as a reference, the Spanish Photobiology Group (GEF) of the Spanish Academy of Dermatology and Venereology (AEDV) has developed some therapeutic guidelines for the most widely used modes of phototherapy: PUVA therapy and narrow-band UVB (NBUVB) therapy. These guidelines deal with generalities about the equipment, calibration and regulation in phototherapy booths, and the concept and indications for these forms of treatment are reviewed. Recommendations are also proposed regarding patient selection, therapeutic procedures, associated pharmacological agents of interest and the prevention and management of adverse effects. The consensus document is designed as a flexible and practical instrument intended for use in daily clinical practice, aimed at optimizing the possibilities of phototherapy while reducing risks for patients and therapists.

Humans↗
PubMed2002

[The Spanish version of Skindex-29. An instrument for measuring quality of life in patients with cutaneous diseases].

BACKGROUND: Quality-of-life studies aim to measure objectively how patient life is affected by disease. Generation of a novel instrument is more expensive and time-consuming than adapting a test already existing in another language. Skindex-29 is a widely validated American instrument to measure quality of life in patients with cutaneous disease. A study of the psychometric properties of the Spanish version of Skindex-29 is presented. PATIENTS AND METHOD: The test was administered to adults in an outpatient dermatological clinic. Age, sex and disease were registered for each patient. Three groups were studied: healthy people, patients with inflammatory skin disease and patients with isolated or tumoral lesions. Construct validity, internal consistency, reproducibility at 72 hours, responsiveness and feasibility were evaluated. RESULTS: Responses of 318 patients were analyzed; 65% were women, with a mean age of 36 years. Validity construction was demonstrated, with significant differences between healthy people and patients as well as between both groups of patients. Reliability was also demonstrated, with Cronbach's coefficient alpha values above 0.84 and intraclass correlation values above 0.7. The test showed responsiveness to clinical change. The percentage of non-response was low, and floor and ceiling effects were adequate. CONCLUSION: The Spanish version of Skindex-29 constitutes an instrument with validity, reliability, and sensitivity to change to measure the effects of cutaneous conditions on quality of life of Spanish patients.

Adult↗
PubMed2002

Sclerodermatous graft-vs-host disease: clinical and pathological study of 17 patients.

OBJECTIVE: To collect and review all cases of sclerodermatous chronic graft-vs-host disease from January 1, 1982, through December 31, 2000. SETTING: University hospital in Madrid, Spain. PATIENTS: During the study period, 493 allogenic bone marrow transplantations were performed. Sclerotic lesions developed in 17 patients. RESULTS: Sclerotic lesions appeared after a mean of 529 days. Previously, 10 (59%) of 17 patients showed a leopard-skin eruption. Sclerosis was generalized in 12 patients and localized in 5. Nine patients presented with rippling of the skin and 8 with lichen sclerosus lesions. We found no anti-Scl-70 or anti-centromere antibodies. Results of histological analysis showed pandermal or deep-dermal sclerosis, slight vacuolar degeneration of the basal cell layer, and follicular damage with follicular plugs. In 6 (50%) of the 12 patients with evaluable biopsy specimens, septal panniculitis was found. Squamous syringometaplasia and mucin deposits were also detected. Treatment with high doses of prednisone and azathioprine helped in 8 of 9 patients. In 12 patients, sclerosis disappeared after 487 days. CONCLUSIONS: Leopard-skin eruption, follicular involvement, ripply skin, and lichen sclerosus lesions have been described poorly or not at all in sclerodermatous graft-vs-host disease. The presence of lichen sclerosus, morphea, septal fibrosis, and fasciitis suggests that the sclerosis can start at and affect any level of the skin. Treatment with prednisone and azathioprine seems to halt the process. Most patients have a good prognosis with treatment. Although most lesions disappear, small areas of fibrosis may remain that do not produce any physical or functional impairment.

Adolescent↗