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Biomedical subjects

Marc H Gorelick

Publications and source records attributed to Marc H Gorelick.

29 records · Page 2Linked to original sources
PubMed2004

Performance of a novel clinical score, the Pediatric Asthma Severity Score (PASS), in the evaluation of acute asthma.

OBJECTIVES: To evaluate the reliability, validity, and responsiveness of a new clinical asthma score, the Pediatric Asthma Severity Score (PASS), in children aged 1 through 18 years in an acute clinical setting. METHODS: This was a prospective cohort study of children treated for acute asthma at two urban pediatric emergency departments (EDs). A total of 852 patients were enrolled at one site and 369 at the second site. Clinical findings were assessed at the start of the ED visit, after one hour of treatment, and at the time of disposition. Peak expiratory flow rate (PEFR) (for patients aged 6 years and older) and pulse oximetry were also measured. RESULTS: Composite scores including three, four, or five clinical findings were evaluated, and the three-item score (wheezing, prolonged expiration, and work of breathing) was selected as the PASS. Interobserver reliability for the PASS was good to excellent (kappa = 0.72 to 0.83). There was a significant correlation between PASS and PEFR (r = 0.27 to 0.37) and pulse oximetry (r = 0.29 to 0.41) at various time points. The PASS was able to discriminate between those patients who did and did not require hospitalization, with area under the receiver operating characteristic curve of 0.82. Finally, the PASS was shown to be responsive, with a 48% relative increase in score from start to end of treatment and an overall effect size of 0.62, indicating a moderate to large effect. CONCLUSIONS: This clinical score, the PASS, based on three clinical findings, is a reliable and valid measure of asthma severity in children and shows both discriminative and responsive properties. The PASS may be a useful tool to assess acute asthma severity for clinical and research purposes.

Adolescent↗
PubMed2004

Association between infant continuity of care and pediatric emergency department utilization.

OBJECTIVE: The objective of this study was to examine the association between continuity of care (COC) and emergency department (ED) utilization during infancy, when the bonds between a provider and a family are first forming and health care utilization is at it highest levels. METHODS: A retrospective birth cohort was conducted of children who were born between December 1, 1999, and April 30, 2000; health care use during the first 25 months of life was analyzed. A COC score was calculated from well-child visits in the first 7 months of life. Subsequent ED utilization, for both a 12-month and an 18-month period, was evaluated through 2 measures: 1) ED reliance (the fraction of all visits that occurred in the ED) and 2) number of ED visits. Spearman rank correlation coefficients (r(s)) between COC and ED utilization were calculated. Partial rank correlations were calculated controlling for Medicaid status, income, gender, and the total number of health care visits. RESULTS: A total of 181 children were included in the study; 96 (53%) were male, and 48 (27%) were covered by Medicaid. COC scores ranged from 0 to 1, with a median of 1. COC scores were negatively correlated with both ED reliance (r(s) = -.214) and number of ED visits (r(s) = -.215) with 12 months of follow-up. The negative correlation was even stronger at 18 months of follow-up (ED reliance: r(s) = -.247; number of ED visits: r(s) = -.242), and this relationship remained significant with partial rank correlations. CONCLUSIONS: Improved COC in infancy is associated with a decrease in subsequent ED utilization. Interventions aimed at increasing the continuity of early well-child visits may decrease ED utilization.

Cohort Studies↗
PubMed2003

Construct validity and responsiveness of the Child Health Questionnaire in children with acute asthma.

OBJECTIVE: To examine the validity and responsiveness of the Child Health Questionnaire (CHQ-PF28) in the context of acute exacerbation of asthma in children. DESIGN AND METHODS: This was a prospective cohort study of children age 5 years and older treated for acute asthma at two urban pediatric emergency departments (EDs). At 14 days after the visit, all patients were contacted by telephone and the CHQ-PF28 (modified to have a 2-week recall period) was administered. Poor 14-day outcome was defined as one or more of the following: child or parent missed at least 5 days of school/day care/work; child still having asthma symptoms above baseline at 14 days; or unscheduled care within 7 days after the ED visit. RESULTS: A total of 732 subjects (median age, 9 years) were enrolled; 622 (85%) had successful follow-up at day 14. At the 14-day follow-up, 254 (43%) were classified as having a poor outcome. The mean physical subscale score of the CHQ-PF28 was 48.2 among those with a good outcome, vs 35.9 among the poor outcome group (difference = 12.3; 95% confidence interval, 10.2 to 14.3). For the psychosocial subscale the average difference between groups was 6.9 (95% confidence interval, 5.1 to 8.7). Among the 146 patients at one site who also had a CHQ score obtained at the initial visit, there was a significant improvement in mean physical subscale score among those with good, but not poor, outcome. However, the relative responsiveness was moderate, with an effect size of only 0.37. CONCLUSIONS: Both the physical and psychosocial subscales of the CHQ-PF28 administered 14 days after an ED visit for acute exacerbation of asthma are correlated with poor short-term functional outcome, but scores are only moderately responsive to acute changes in functional status.

Acute Disease↗
PubMed2003

Effect of ethnicity and race on the use of pain medications in children with long bone fractures in the emergency department.

STUDY OBJECTIVES: We characterize the use of analgesics among children of different race and ethnicity who had isolated long bone fractures that were treated in emergency departments (EDs) across the United States. METHODS: According to ED survey data from the National Hospital Ambulatory Medical Care Survey for 1992 through 1998, patients younger than 19 years and visiting EDs with isolated long bone fractures were identified by International Classification of Diseases, Ninth Revision codes. Analgesic-prescribing rates were examined for children of different racial and ethnic groups. Multivariate logistic regression was used to determine the independent effect of race and ethnicity on analgesic use and on opioid use while other potential confounders were controlled. RESULTS: One thousand thirty records representing approximately 3.9 million children were identified. Seven hundred ninety-two records were of non-Hispanic white patients, 111 were of black patients, and 127 were of Hispanic white patients. No significant difference was noted among the different racial and ethnic groups for receipt of analgesic medications or of opioid analgesic medications. Children with long bone fractures who visited the ED in the South (adjusted odds ratio [OR] 1.91; 95% confidence interval [CI] 1.19 to 3.09) and the West (adjusted OR 1.78; 95% CI 1.07 to 2.96) received opioid analgesic medications more often than children in the Northeast. Children in the South also received any analgesics more often (adjusted OR 1.61; 95% CI 1.01 to 2.56). CONCLUSION: No difference in analgesic prescription or opioid analgesic prescription was found between black and Hispanic children compared with non-Hispanic white children with long bone fractures in EDs. There are, however, previously unreported regional differences in analgesic administration.

Adolescent↗
PubMed2003

Interrater agreement in the clinical evaluation of acute pediatric asthma.

Prior studies of observer agreement of the clinical exam of children with asthma have focused on small numbers of specially trained observers, often in the setting of clinical trials. Our objective was to evaluate interobserver reliability in the physical exam of acute pediatric wheezing and asthma among a large group of diverse examiners, in a setting of routine clinical practice, and without prior special training. The setting was a large urban children's hospital. Observers were attending pediatric emergency physicians and fellows; hospital respiratory therapists; and emergency department (ED) nurses. Patients were children receiving nebulized medications for wheezing in the ED or inpatient asthma unit. Pairs of observers simultaneously but independently rated work of breathing, wheeze, decreased air entry, prolonged expiration, breathlessness, respiratory rate, mental status, and global (or overall) severity using a structured exam template. A total score for each exam was also evaluated. A total of 230 pairs of observations were performed; mean patient age was 5.3 years. For all pairs, the weighted kappa statistics for the exam components ranged from 0.61 to 0.74 (moderate or substantial agreement). The global severity category and total score had weighted kappas of 0.80 and 0.82, respectively (excellent agreement). Agreement was generally somewhat lower for unlike (different profession) observer pairs than for like observer pairs, but remained acceptable. Agreement in two age groups (< or = 3 years old and > or = 4) was at least moderate for all exam components analyzed. Spearman rank correlations between individual exam components and the global assessments of patient severity were all greater than 0.5, indicating at least moderate to good correlations. We found substantial interobserver agreement among a broad range of examiners in the components of the clinical examination of acute wheezing in both younger and older children. This is contrary to the commonly held observation that the poor interobserver reliability of physical exam findings in asthma may limit their usefulness as asthma outcome measures. Support for use of a structured respiratory exam format or template in asthma guidelines was also shown.

Acute Disease↗
PubMed2003

Pediatric emergency department directors' benchmarking survey: fiscal year 2001.

OBJECTIVES: To answer basic questions, using precise definitions, regarding emergency department (ED) utilization, wait times, services, and attending physician staffing of representative pediatric EDs (PEDs). METHODS: Ten questions with precise definitions were developed and sent to members of the Ambulatory Pediatric Association's PED Directors' Special Interest Group in November of 2001, with two repeated requests 3 and 6 months later. RESULTS: Twenty-one PEDs from 14 states, the District of Columbia, and Canada responded (41%). The average PED has 48,000 patient visits per year (range, 25,000-97,000). Two thirds have urgent care or fast track areas to see nonurgent patients, while only 29% have 23-hour treatment units. The average admission rate is 13.2% (range, 6.8-20.8%). The average rate of patients who leave without being seen is 1.6%. The average patient waits 1 hour to see a physician and spends a total of 3 hours in the PED. The majority of attending staffing is by pediatric emergency medicine (PEM) Board-certified/eligible physicians (73%), although a few PEDs are staffed only by PEM specialists. Attending staffing is 2.8 patients per attending per hour, or 0.36 hours per patient, with more staffing for PEDs with higher admission rates or acuity. The average entry-level base salary for PED physicians in 2000 was 117,250 dollars (range, 98,000 dollars-145,000 dollars). CONCLUSIONS: Benchmarking of PEM staffing and performance indicators by PEM directors yields important administrative data. PEDs have higher census and admission rates compared with information from all EDs, while their attending staffing, wait times, and rate of patients who leave without being seen are comparable to those of general EDs.

Benchmarking↗
PubMed2003

Validation of a decision rule identifying febrile young girls at high risk for urinary tract infection.

OBJECTIVE: To validate a previously published clinical decision rule to predict risk of urinary tract infection in febrile young girls. METHODS: We performed a retrospective case-control study at a children's hospital emergency department in a different city than that in which the original derivation study took place. Girls younger than 2 years in whom urinalysis and urine culture were performed for evaluation of fever were eligible. Cases consisted of all patients with a positive urine culture result, defined as 50,000 or more colony-forming units per milliliter of a urinary tract pathogen (n = 98). A random sample of patients with a negative urine culture result (n = 114) was also selected as controls. The clinical prediction rule included five risk factors: age younger than 12 months, white race, temperature of 39.0 degrees C or higher, absence of any other potential source of fever, and fever for 2 days or more. The sensitivity and false-positive rate of this rule were calculated at different cutoff values. RESULTS: The overall discriminative ability of the rule, as indicated by the area under the receiver-operator characteristic curve (AUC), was similar in this validation sample (AUC = 0.72) to that in the original study (AUC = 0.76). However, in the validation sample, the presence of three or more risk factors (rather than two or more as in the original study) appeared to be the optimum cutoff to define a positive rule, which results in an indication for obtaining further diagnostic testing (sensitivity, 88% [95% CI, 79-94%]; false-positive rate, 70% [95% CI, 61-79%]). CONCLUSION: A simple clinical decision rule previously developed to predict urinary tract infection based on five risk factors performs similarly in a different patient population.

Area Under Curve↗
PubMed2002

Comparability of acute asthma severity assessments by parents and respiratory therapists.

OBJECTIVE: To compare the assessments of parents and respiratory therapists (RTs) of acute asthma severity in children discharged after emergency department (ED) treatment. DESIGN: Prospective cohort study. SETTING: Home care visit within 24 hours of discharge from an urban children's hospital ED. PARTICIPANTS: Children aged 2 to 17 years discharged to home after treatment in the ED (at least 1 inhaled bronchodilator treatment administered) were randomly selected to have a home care visit. MAIN OUTCOME MEASURES: Registered RTs went to the child's home and asked the parent questions about his or her perception of the child's symptoms. The RT performed a clinical assessment including pulse oximetry. RESULTS: Ninety children were selected for home care, and 51 patients (57%) successfully completed the home care visit; 48 (53%) underwent a complete assessment by both raters. There were no differences in demographic features or ED clinical variables between those successfully contacted and those not reached. Of those evaluated, 43 parents (84%) reported their child's asthma was improved, and the rest reported no change. Parents underestimated the degree of wheezing or work of breathing relative to the RT in 3 of 48 patients (6%), but only 1 of these was considered substantial (>1 point discrepancy). Findings were overestimated in 14 (29%) of 48 cases, but only 5 (10%) were substantial. CONCLUSIONS: Parents and RTs provide comparable assessments of acute asthma severity in children within 24 hours of discharge from the ED. Clinically important discrepancies are uncommon, and underestimation of severity by parents is rare.

Adolescent↗