Marcel Hoogenraad | PubMed Health

PubMed2003

Advances in multivariate analysis in pharmaceutical process development.

In the last five years, reports of the application of multivariate methods in pharmaceutical process research and development have burgeoned. Examples range from the widespread adoption of statistical experimental design for screening and process optimization to the implementation of workflows that integrate multivariate characterization, experimental design and the development of quantitative structure-property relationships. Having learned from the application of these techniques in drug discovery and armed with modern high-throughput experimentation platforms, practitioners are discovering the power of experimental design and multivariate methods for shortening process development timelines.

Drug Evaluation, Preclinical↗

PubMed2002

Tris[2-(2-oxazolin-2-yl)phenolato]iron(III).

The title compound, tris[2-(4,5-dihydrooxazol-2-yl-kappa N)phenolato-kappa O]iron(III), [Fe(C(9)H(8)NO(2))(3)], is disordered over a non-crystallographic twofold rotation axis perpendicular to the crystallographic threefold rotation axis. The disorder can be a pure rotational disorder of an iron complex in the facial configuration, or the consequence of a mixture of facial and meridional configurations. In the latter case, at least 25% of the iron complexes must adopt the facial configuration in order to obtain the disorder ratio observed in the crystal.

Journal Article↗