Biomedical subjects

Marcelo Nascimento Burattini

Publications and source records attributed to Marcelo Nascimento Burattini.

7 recordsLinked to original sources

PubMed2005

Yellow fever vaccination: how much is enough?

In recent years, a growing number of serious adverse events (including deaths) associated with the yellow fever (YF) vaccine has been reported. If YF vaccination were incorporated in routine programs, administered to children, the risk of deaths from this vaccine would be minimized provided that mortality of children vaccinated below 1 year were negligible. However, in affected areas the vaccine is administered to all age groups. This poses a dilemma to public health authorities - what proportion of a population subject to low risk of YF outbreaks should be vaccinated in order to minimize the total number of serious adverse events (including deaths) due both to natural infection and vaccination? In other words, how much vaccination is safe? Our results suggest that, depending on the age-specific rates of developing vaccine-induced serious adverse events and the risk of yellow fever outbreaks, the optimum proportion to vaccinate may be lower than the proportion that would prevent an epidemics or even be zero. We also show that the vaccine should not be applied to individuals older than 60 years of age because the risk of serious adverse events (including deaths) is higher for that age class. Our work is instrumental to the discussion on the optimum strategy to vaccinate affected populations against yellow fever. Therefore, the aim of this work is to estimate the optimum proportion to vaccinate against YF taking into account the risks of serious adverse events associated with both the vaccine and natural infection.

Adolescent↗

PubMed2005

Seroprevalence of hepatitis B virus and hepatitis C virus in Monte Negro in the Brazilian western Amazon region.

PURPOSE: This study was carried out in Monte Negro (state of Rondônia), a village in the Brazilian western Amazon region, where a University of São Paulo Medical School program for medical student training in rural assistance took place. It aimed to determine the prevalence of hepatitis B virus and hepatitis C virus, to investigate risk factors for infection, and to evaluate the State immunization program against hepatitis B virus in the region. METHODS: The study is a cross-sectional seroprevalence survey, comprising 267 volunteers who answered a comprehensive questionnaire and had blood samples collected, which were analyzed in São Paulo for the presence of antibodies against hepatitis B virus (Hbs Ag, anti-Hbs, and anti-Hbc) and hepatitis C virus using commercial kits. Data were stored in a specific data bank, and the association between seropositivity and potential risk factors was analyzed by means of uni-, bi-, and multi-variate analysis, considering +/- 5%. RESULTS: The seroprevalence of hepatitis B virus was 61.79% and of hepatitis C virus was 0.38%. Statistical analysis on the data bank showed that the prevalence of hepatitis B virus rose significantly with age, especially after adolescence. Infection was higher in those coming from outside the state of Rondônia. Exposure to vaccination against hepatitis B virus was higher in younger individuals and in those who were born in Rondônia. CONCLUSION: Monte Negro is a highly endemic region for hepatitis B virus but not for hepatitis C virus. Our results also provide indirect evidence indicating a significant improvement in the immunization program in Rondônia in recent years.

Adolescent↗

PubMed2004

Anopheles albitarsis s.l. (Diptera: Culicidae) survivorship and density in a rice irrigation area of the state of São Paulo, Brazil.

Collections of Anopheles albitarsis Arribalzaga s.l. were conducted from May 1996 to June 2000 to estimate the human biting rate, and mark-release-recapture experiments were carried out to estimate the daily survival probability. The density of An. albitarsis females showed a marked seasonal variation, with peaks as high as 629 individuals per human per night in the wet season. The low daily survival probability of 0.61 is an important factor limiting the vectorial capacity of An. albitarsis s.l. in southeastern Brazil.

Animals↗

PubMed2003

Dengue and the risk of urban yellow fever reintroduction in São Paulo State, Brazil.

OBJECTIVE: To propose a mathematical method for the estimation of the Basic Reproduction Number, R0, of urban yellow fever in a dengue-infested area. METHODS: The method is based on the assumption that, as the same vector (Aedes aegypti) causes both infections, all the quantities related to the mosquito, estimated from the initial phase of dengue epidemic, could be applied to yellow fever dynamics. It is demonstrated that R0 for yellow fever is, on average, 43% lower than that for dengue. This difference is due to the longer dengue viremia and its shorter extrinsic incubation period. RESULTS: In this study the analysis was expanded to the epidemiological situation of dengue in S o Paulo in the year 2001. The total number of dengue cases increased from 3,582 in 2000 to 51,348 in 2001. It was then calculated R0 for yellow fever for every city which have shown R0 of dengue greater than 1. It was also estimated the total number of unprotected people living in highly risky areas for urban yellow fever. CONCLUSIONS: Currently there is a great number of non-vaccinated people living in Aedes aegypti infested area in the state of São Paulo.

Aedes↗

PubMed2003

Fuzzy epidemics.

The purpose of this paper is to provide a review of the current state of fuzzy logic theory in epidemiology, which is a recent area of research. We present four applications of fuzzy logic theory in epidemic problems, using linguistic fuzzy models, possibility measure, probability of fuzzy events and fuzzy decision making techniques. The results demonstrate that the applications of fuzzy sets in epidemiology is a very promising area of research. The final discussion sets the future stage of fuzzy sets application in epidemiology.

Acquired Immunodeficiency Syndrome↗

PubMed2002

Threshold conditions for infection persistence in complex host-vectors interactions.

As classically defined by Macdonald in the early 1950s, for the case of diseases with one vector and one host, the Basic Reproduction Number, R0, is defined as the number of secondary infections caused by a single infective of the same type (vector or host) during its infectiousness period in an entirely susceptible population. In the case of a disease which has one vector and one host, it is easy to show that R0 coincides with the threshold for the establishment of an endemic state: if R0 > 1 (< 1), the disease can invade (cannot invade) the host population. In this paper we examine various epidemic situations in which there are more than one vector and/or host. We show that in those more complex systems it is not possible to deduce a single R0 but rather a threshold for infection persistence which is a composite of several quantities closely related to the classical expression of R0. Another definition of R0 given by Diekmann, Heesterbeek and Metz, and denoted in this paper R0NGO is discussed and applied as an alternative to calculate the thresholds for infection establishment.

Animals↗

PubMed2002

Laboratory and field observations on duration of gonotrophic cycle of Anopheles albitarsis s.l. (Diptera: Culicidae) in southeastern Brazil.

Mark-release-recapture experiments were conducted to determine the duration of the gonotrophic cycle of Anopheles albitarsis s.l. in Ribeira Valley, State of Sao Paulo, Brazil. Separate experiments with females collected from the field were followed under laboratory conditions. A mean of 2.4 d was characteristic for the gonotrophic cycle for wild-caught females, whereas 4.4 d was characteristic for females in the laboratory conditions.

Animals↗