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Biomedical subjects

Marcia Ramos-e-Silva

Publications and source records attributed to Marcia Ramos-e-Silva.

At least 19 recordsLinked to original sources
PubMed2007

Clinical and immunohistochemical assessment of the effect of cyclosporin in keratinocytes and dermal dendrocytes in psoriasis.

BACKGROUND: Cyclosporine is a potent immunosupressor, which induces cytokeratin expression pattern changes and dermal dendrocytes number increase. OBJECTIVES: To evaluate its clinical effect in psoriasis, on keratinocytic proliferation and differentiation, and on dermal dendrocytes proliferation. METHODS: Thirty patients with psoriasis were treated and evaluated for 8 weeks. Clinical improvement was evaluated by Psoriasis Area and Severity Index (PASI). Biopsies were performed initially and after 8 weeks. Immunohistochemistry [CK markers 10, 14, and 16, and factor XIIIa+ (FXIIIa+)] was performed. RESULTS: Mean PASI before treatment was 26.32 and 3.71 after. Mean initial and final PASI difference was 22.61 (p < 0.001). Two patients had serum creatinine and six uric acid increase. Before and after treatment, mean numbers per field of dermal dendrocytes were 7.07 and 3.68, respectively. Mean difference was 3.39, with p < 0.001. CK10 immunohistochemical pattern demonstrated recovery of normal expression pattern in 26 patients, while CK14 pattern demonstrated improvement in 21 patients. CONCLUSIONS: Cyclosporine was effective and safe for psoriasis in low doses, with significant decrease of PASI and dermal dendrocytes number after 8 weeks of therapy. CK10 and 14 pattern changed and, less prominently, CK16 expression. These modifications occur later than the PASI and dermal dendrocytes variation.

Adult↗
PubMed2006

Most common oral alterations in the elderly--a review.

The population of Brazil is experiencing a fast and progressive aging process. Oral mucosa, which has a function as a barrier, is compromised by the aging process, allowing the action of predisposing agents. The older the population, the greater is the prevalence of lesions in oral mucosa. The causes may be neoplastic, infectious, bone pathologies, oral manifestations of systemic diseases, nutritional deficiencies, dental prostheses, medicaments, and bullous diseases, among others. Examination of the oral cavity should be carried out as an annual routine, and as a preventive measure for the entire elderly population, in order to reduce the morbidity and mortality from these diseases.

Age Factors↗
PubMed2005

Eosinophilic fasciitis (Shulman syndrome).

We present a case of eosinophilic fasciitis, or Shulman syndrome, in a 35-year-old man and discuss its clinical and histopathologic aspects, as well as its relationship to scleroderma. Although controversial, the tendency is to set Shulman syndrome apart from all other sclerodermiform states.

Adult↗
PubMed2005

Physiologic alterations of oral mucosa due to aging: a review.

The Brazilian population, despite Brazil being considered a "country of young people", is undergoing an aging process entailed by a decline in the fertility and mortality rates. In the year 2000, seniors accounted for about 5.85% of the Brazilian, and population projections for 2025 estimate that the group will reach 14% by that time. Oral mucosa has a function of providing a barrier and promoting immune and inflammatory responses, thus protecting the body. During the aging process, those functions deteriorate, allowing the action of predisposing agents. There is thus the need of better knowledge of the conditions of oral health in the Brazilian population, allowing for adoption of preventive measures. Oral cavity examination should be routinely performed in the elderly on a yearly basis, as a preventive measure which would reduce the morbidity and mortality in this population.

Aging↗
PubMed2005

Expression of keratins 14, 10 and 16 in marginal keratoderma of the palms.

Marginal keratoderma of the palms (MKP), also known as degenerative collagenous plaques of the hands, is an infrequent disease affecting individuals with photoaged skin and submitted to mechanical trauma of the hands. The aim of the study was to study the expression of keratin 14 (K14) in the basal layer and keratins 10 (K10) and 16 (K16) in the suprabasal layer, and to establish the effect of growth factors and receptors of the epidermal growth factor in the genesis of hyperkeratosis observed in MKP. The study included 14 patients with MKP. Expression of keratins 10, 14 and 16 was visualized by immunohistochemical staining using monoclonal antibodies by standard immunoperoxidase method. As control three normal skin samples were used. Absence or weak expression of keratins 14 and 10, and strong expression of keratin 16 was recorded in MKP patients. It was concluded that MKP patients present weak expression of keratins 14 (basal membrane) and 10 (suprabasal layer) but strong expression of keratin 16, emphasizing the importance of stimulation of epidermal growth factor receptors by ultraviolet radiation and traumatism.

Aged↗
PubMed2004

Cutis verticis gyrata secondary to a cerebriform intradermal nevus.

We report the case of a 30-year-old black man with a large mass consisting of longitudinal parallel ridges and furrows on the left parietal region. A small, single, hyperpigmented macule was present at birth and gradually grew and extended over the years. Cutis verticis gyrata was suspected, and an investigation was performed to discharge the possibility of pachydermoperiostosis. However, results of biopsies obtained from 3 different lesional areas showed the same histopathologic features--deep-seated hair follicles and clusters of nevus cells concentrated in the dermis. Cerebriform intradermal nevus is a rare cause of cutis verticis gyrata. Early diagnosis is extremely important to prevent the development of malignant melanoma.

Adult↗
PubMed2004

Bowenoid papulosis in a patient with AIDS treated with imiquimod: case report.

A 53-year-old male patient with acquired immunodeficiency syndrome (AIDS) was treated with topical immunomodulator imiquimod for bowenoid papular. Clinically the lesions presented as condilomatous and papulous changes with color varying from skin color to grayish. The lesions were located in the glans and in the dorsum of the penis. Clinical diagnosis was confirmed by histopathological examination, and the polymerase chain reaction (PCR) demonstrated the presence of human papilloma virus (HPV) 16. It was decided to apply a topical treatment with imiquimod 5% cream three times a week for 16 weeks. Almost complete regression was obtained; the residual lesions were treated with a combined chemical cauterization by using 50% trichloroacetic acid followed by 25% podophylin. Although it is not a definitive treatment, the use of topical immunomodulator is one more therapeutic option in the selected HPV cases.

Acquired Immunodeficiency Syndrome↗
PubMed2003

Stomatodynia or burning mouth syndrome.

We reviewed the literature on stomatodynia particularly to identify the factors associated with this annoying manifestation in order to better understand it and treat it. No consensus was found in the literature regarding etiological factors, associated morbidity, treatment, and definition of the burning mouth syndrome. This review aims at defining the disease, its characteristics, criteria for the diagnosis, and treatment.

Burning Mouth Syndrome↗
PubMed2002

Cardio-facio-cutaneous syndrome: a case report.

Cardio-facio-cutaneous syndrome is a genetic disorder with a characteristic facies, abnormal skin and hair, mental retardation and congenital heart disease. It may be confused with Noonan's syndrome, which has a familial pattern and does not present hyperkeratotic skin lesions and abnormal hair, and there are few cases reported in the literature. We describe the first case of typical cardio-facio-cutaneous syndrome observed in Brazil.

Abnormalities, Multiple↗
PubMed2002

Lesion of a lower lip scar--an initial presentation of sarcoidosis.

The development of sarcoidosis at the site of previous scar is unusual and may be the first sign of systemic disease. Sarcoidosis on a lower lip scar persisting for 13 years, which pointed to examination for internal manifestations, is presented along with a review of the subject

Adult↗
PubMedDate not supplied

Life-threatening eruptions due to infectious agents.

Some infectious diseases may cause rapidly fatal eruptions that need to be diagnosed and treated in an early phase for patient survival. The main life-threatening eruptions of infectious etiology include Rocky Mountain spotted fever, meningococcemia, toxic shock syndrome, streptococcal toxic shock syndrome, and staphylococcal scalded skin syndrome.

Bacteremia↗