PubMed Health⌕ Search

Biomedical subjects

Marcin Cwynar

Publications and source records attributed to Marcin Cwynar.

4 recordsLinked to original sources
PubMed2003

[Laser doppler flowmetry--repeatability of the method].

The aim of the study was to evaluate the repeatability of flow microcirculation measurements by laser doppler flowmetry (Periflix, firm Perimed, Sweden). Measurements of right forearm skin perfusion were performed twice in 3-4 day intervals in 40 healthy subject aged 39.5 +/- 18.3. Two independent investigators analysed the results. Pearson correlation and analysis ac. Bland and Altman (Lancet 1986, 1, 307-310) were performed during comparing results obtained in the same studied persons and by the investigators. There was a high correlation between the compared results performed on the same subjects within a few days interval, especially between the results for post-occlusive congestion reaction in basic temperature (r = 0.64-0.72) and the results for congestion reaction at a temperature of 44 degrees C (r = 0.5-0.56). High correlation values (r = 0.8-0.95) were also observed when comparing both investigators' evaluations. Repeatability evaluation using Bland and Altman analysis was poorer, especially for values observed in resting conditions and for some values observed after stimulation with both investigators (2.5-10% of results were out of interval: mean +/- 2SD). The results show good repeatability of microcirculation flow measurements, especially under stimulation.

Adult↗
PubMed2002

[Mechanisms of large artery remodeling].

Degenerative changes of elastin, increase of collagen fibres, proliferation of muscle cells and impairment in endothelium function occurs in the vessel wall with ageing, in hypertensive and others diseases. Early changes are potentially reversible. Atherosclerosis is a late stage of pathologies occurring in the arterial wall in response to various factors. The present paper describes current knowledge on mechanisms of arterial wall remodelling. The authors define basic indices of arterial compliance and describe several physiological and pathological factors which occur play the main role in process of arterial wall remodelling. A chapter is devoted to the effects of increased arterial stiffness on heart pathology and clinical implications of measuring these parameters.

Age Factors↗
PubMed2002

[Pulse wave analysis: from the basic sciences to clinical applications].

Assessment of the pulse character is one of the earliest recorded medical skills, but objective recordings of pulse waveform emerged only in the nineteenth century. This technique fell into disuse with the advent of the sphygmomanometer, but interest has recently been rekindled with the introduction of computer technology and high fidelity applanation tonometry. Sphygmocardiography is a non-invasive and accurate technology which utilizes tonometric analysis of the radial or carotid artery pulse wave and measurement of peripheral arterial blood pressure to derive a central arterial pulse wave, central arterial blood pressure and related indices. In clinical studies pulse wave analysis is a highly reproducible method and easy to apply. This measure provides important information about arterial stiffness and heart-vascular interactions. This technique may provides better cardiovascular risk assessment associated with increased arterial stiffness and allow treatment to be targeted to those most in need.

Blood Pressure↗