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Biomedical subjects

Marcio Nucci

Publications and source records attributed to Marcio Nucci.

21 records · Page 2Linked to original sources
PubMed2002

Should vascular catheters be removed from all patients with candidemia? An evidence-based review.

The removal of all central venous catheters (CVCs) from all patients with candidemia is considered to be standard care. However, this practice is not always possible, and it is associated with significant cost and potential complications. To evaluate the effect of CVC removal on the outcome of patients with candidemia, a literature review was conducted that selected studies that evaluated CVC removal as a prognostic factor (of mortality) in candidemia, performed a multivariate analysis with odds ratios and 95% confidence intervals, and included a validated severity of illness score. Of 203 studies of candidemia, only 4 fulfilled these criteria. One study showed a benefit from CVC removal in a subset of 21 neutropenic patients; another study showed no benefit; and the remaining 2 studies showed a marginal benefit from this strategy. Although it is possible that removal of CVCs may reduce the rate of complications due to candidemia, including death, the findings of this literature review do not substantiate this consensus recommendation.

Candidiasis↗
PubMedDate not supplied

Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease.

This report describes the results of a multicenter study designed to determine the efficacy and toxicity of a novel combination (ABVP) in patients with newly diagnosed Hodgkin's disease. The ABVP protocol is a modification of ABVD in which prednisone is substituted for DTIC. In order to attempt an increase in drug intensity, doxorubicin, bleomycin and vinblastine were administered on days 1 and 8 of each cycle, and a new cycle began on day 22. Patients who developed phlebitis were allowed to receive the drugs every two weeks. Patients with bulky mediastinal disease received involved field radiation therapy after chemotherapy. Fifty-one patients were treated. Complete remission was achieved in 40 patients (78%). Actuarial failure-free survival in 55 months was 59%, and overall survival was 81%. The overall survival for the 32 patients treated with the intensified regimen was higher than that for those who switched to the bi-weekly schedule (89% vs. 68%, p=0.03). ABVP appears to be equivalent to ABVD. The higher overall survival rate in patients treated every 21 days suggests that this intensified schedule might be more effective. The placement of a Port catheter is recommended, due to the high incidence of phlebitis.

Adolescent↗