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Biomedical subjects

Margaret E Hellard

Publications and source records attributed to Margaret E Hellard.

16 recordsLinked to original sources
PubMed2006

The evidence for a change in antenatal HIV screening policy in Australia.

Australia is one of the few developed countries without routine antenatal HIV screening, despite having the resources to undertake such a screening program and the availability of antiretroviral therapy. National policy recommends that only women with identified risk factors should be offered testing; however, the Royal Australian and New Zealand College of Obstetricians and Gynaecologists recommends that all pregnant women be offered HIV testing as part of their antenatal care. Knowledge of a woman's HIV status during pregnancy allows interventions to improve her health and reduce the risk of transmission of HIV to her child. A universal antenatal HIV screening program meets many of the Wilson and Jungner criteria for population-based screening programs. This should be considered in the current review of Australia's HIV testing policy.

Australia↗
PubMed2006

Impact of an education campaign on management in pregnancy of women infected with a blood-borne virus.

OBJECTIVE: To assess obstetricians' antenatal screening practice for blood-borne viruses (HIV, hepatitis B and C viruses [HBV and HCV]) and knowledge about management during labour and risk of transmission via breastfeeding for infected women after an educational intervention, Australia. DESIGN: Cohort study, with surveys before and after an educational intervention. SETTING AND PARTICIPANTS: Survey 1 was mailed in 2002-2003 to all 767 Fellows registered with the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG), and Survey 2 was mailed in 2004 to the 743 of these Fellows who were still practising. INTERVENTION: Multifaceted intervention with mail-out of survey results and a summary of recommended management, publication of two review articles in the RANZCOG journal, and an oral presentation at the RANZCOG annual scientific meeting. MAIN OUTCOME MEASURES: Self-reported frequency of antenatal screening for blood-borne viruses, change in practice based on a woman's infection status, and advice given about risk of virus transmission via breastfeeding in Survey 2, compared with Survey 1. RESULTS: Survey 2 (response rate, 68%) found increases from the previous survey in the proportion of respondents reporting they always offered antenatal screening for HIV, from 51% to 59%, and for HCV, from 60% to 69% (P = 0.001 for both). For women with HIV infection, the proportion of respondents always recommending elective caesarean section increased from 37% to 49% (P = 0.001) and always avoiding rupture of membranes increased from 33% to 49% (P < 0.001). The proportion who reported advising (incorrectly) that breastfeeding is associated with increased risk of transmission to the infant decreased from 34% to 25% for HBV (P = 0.01) and from 47% to 39% for HCV (P = 0.03). CONCLUSION: The frequency of antenatal testing for HIV and HCV is increasing in Australia. Knowledge about interventions to reduce mother-to-child transmission of HIV and knowledge of the risk of HBV and HCV transmission via breastfeeding improved after a relatively simple educational intervention.

Australia↗
PubMed2006

The prevalence and risk behaviours associated with the transmission of blood-borne viruses among ethnic-Vietnamese injecting drug users.

OBJECTIVE: To measure the prevalence and determinants of blood-borne virus (BBV) transmission in ethnic Vietnamese injecting drug users (IDUs). METHODS: The study was conducted in Melbourne, Australia, in 2003. It was a cross-sectional design with participants recruited from street-based illicit drug markets predominately using a snowball technique. One hundred and twenty-seven participants completed a questionnaire that asked about illicit drug use and participants' blood samples were tested for HIV, HCV and HBV. RESULTS: One hundred and three (81.1%) ethnic Vietnamese IDU study participants were HCV positive and three (2.4%) were HIV positive. More than 60% had evidence of being infected with HBV (either in the past, acute infection or chronic infection). Almost 60% had injected daily over the past 12 months. Fifty-nine participants had recently travelled to Vietnam; 24 (41%) had injected drugs in Vietnam; and three (12.5%) reported sharing injecting equipment in Vietnam. CONCLUSION: The prevalence of BBVs was higher in this study's IDU population compared with IDUs in Australia generally, despite the fact that the injecting risk behaviours were similar to IDUs more generally. IMPLICATIONS: Culturally sensitive drug treatment and education programs need to be developed in Australia for both ethnic Vietnamese IDUs and their families to reduce this group's risk of contracting a BBV.

Adolescent↗
PubMed2006

A profile of HIV testing in Victoria, 1984 to 2004.

HIV testing is an important public health strategy and collection of HIV testing data is a component of overall HIV surveillance activities. This paper describes changes in HIV testing patterns in relation to HIV diagnoses in Victoria between 1984 and 2004. HIV testing and diagnosis data were extracted from surveillance databases maintained at the Burnet Institute. The annual number of HIV tests performed in Victoria increased from 2,879 in 1984, to 193,927 in 2004. Between 1991 and 2004, the male HIV testing rate per 100,000 population increased from 2,754 to 3,710 and the female rate from 2,395 to 4,453. The proportion of HIV tests conducted by private laboratories increased from less than 1 per cent in 1991 to 75 per cent in 2004. The number of HIV diagnoses increased from 140 in 1999 to 233 in 2002 and then fell to 217 in 2004. The HIV diagnosis rate per 100,000 tests increased from 98.9 in 1999 to 137.7 in 2000 then decreased to 111.9 in 2004. The overall rate of HIV diagnosis per 100,000 tests was 291.6 for males and 25.9 for females. Increased testing among males is a good outcome considering the majority of HIV diagnoses in Victoria are among men who have sex with men (MSM). Increased testing among females probably relates to increased antenatal screening. The inability to collect sexual orientation and reason for test data limited interpretations. To provide a better understanding of the impact of testing on the HIV epidemiology, especially among MSM, linked HIV sentinel surveillance has been implemented in Victoria.

Adult↗
PubMed2005

The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute.

OBJECTIVES: To determine the overall rate of loss of workplace teaspoons and whether attrition and displacement are correlated with the relative value of the teaspoons or type of tearoom. DESIGN: Longitudinal cohort study. SETTING: Research institute employing about 140 people. SUBJECTS: 70 discreetly numbered teaspoons placed in tearooms around the institute and observed weekly over five months. MAIN OUTCOME MEASURES: Incidence of teaspoon loss per 100 teaspoon years and teaspoon half life. RESULTS: 56 (80%) of the 70 teaspoons disappeared during the study. The half life of the teaspoons was 81 days. The half life of teaspoons in communal tearooms (42 days) was significantly shorter than for those in rooms associated with particular research groups (77 days). The rate of loss was not influenced by the teaspoons' value. The incidence of teaspoon loss over the period of observation was 360.62 per 100 teaspoon years. At this rate, an estimated 250 teaspoons would need to be purchased annually to maintain a practical institute-wide population of 70 teaspoons. CONCLUSIONS: The loss of workplace teaspoons was rapid, showing that their availability, and hence office culture in general, is constantly threatened.

Academies and Institutes↗
PubMed2005

Improving HIV surveillance in Victoria: the role of the "detuned" enzyme immunoassay.

Between 1999 and 2000, new diagnoses of HIV in Victoria (Australia) rose by 41%, from 140 to 197. In this time period, sera from new HIV diagnoses were tested using the Organon Teknika "detuned" enzyme immunoassay (EIA). We compared the results of the detuned EIA with incident infections defined by surveillance (on the basis of a previous negative or indeterminate HIV test and/or a seroconversion illness within the 12 months preceding HIV diagnosis). Of 317 specimens, 97 (31%) incident infections and 114 (36%) recent infections were detected using surveillance and detuned EIA, respectively. The detuned assay misclassified 11 cases with AIDS and 2 cases with CD4 counts < or = 200 micro3 (probable long-standing infections) as recent infections and was unable to identify 31 (32%) of 97 cases previously classified as incident cases by surveillance. The assay detected an extra 35 recent infections that were previously classified as nonincident by surveillance. By combining the detuned assay and surveillance, 132 (42%) incident infections were identified from 317 specimens, 36% more than surveillance alone. We recommend that a detuned assay or similar test become part of the routine strategy to identify incident infections in Victoria. Incident infections provide important information for targeting prevention strategies and the opportunity to interrupt ongoing viral transmission.

Adolescent↗
PubMed2005

No correlation between clinical symptoms and Blastocystis hominis in immunocompetent individuals.

UNLABELLED: Abstract Background and Aim: Previous reports regarding the clinical significance and pathogenicity of Blastocystis hominis have been contradictory. The aim of this study was to examine the association between Blastocystis and gastrointestinal symptoms in immunocompetent individuals. METHODS: We monitored over 2800 healthy people for a period of 15 months, and took stool specimens during both asymptomatic periods and during periods of gastrointestinal symptoms. RESULTS: After exclusion of individuals who had simultaneous identification of other fecal pathogens, we compared the proportions of asymptomatic versus symptomatic individuals positive for Blastocystis and found no significant difference (P = 0.5). Symptom status did not correlate with parasite abundance. We found that some individuals were likely to have Blastocystis detected during both asymptomatic and symptomatic periods, possibly suggesting carriage of the organism. CONCLUSION: In conclusion, we found no correlation between clinical symptoms and the presence or absence of Blastocystis among this healthy cohort.

Adolescent↗
PubMed2005

Pathogens causing community gastroenteritis in Australia.

BACKGROUND AND AIM: Many individuals with gastrointestinal symptoms do not seek medical attention and so there is little known about the pathogens involved in most cases of community gastroenteritis. We aimed to identify the pathogens responsible for community gastroenteritis and to examine the associated symptoms. METHODS: In a prospective study of 2811 subjects over 15 months, fecal pathogens were examined following highly credible gastroenteritis (HCG) events. The population consisted of family units of at least two children (< or =15 years-old) and two adults each. Fecal samples were tested for a range of bacterial, viral and protozoal pathogens. Gastroenteric episode duration and symptoms such as vomiting, nausea and diarrhea were measured. RESULTS: One or more pathogens were identified in 198 of a total 791 specimens collected. Pathogens detected most often were Norovirus virus (10.7%), pathogenic E. coli (6.7%), Campylobacter spp. (3.0%) and Giardia sp. (2.5%). Children were more prone than adults to all the pathogens tested, except E. coli. Children infected with Campylobacter were 8.3 times more likely (95% CI: 2.7-25.4) to have a longer duration of diarrhea than children with Norovirus (P < 0.001). Similarly, children infected with E. coli had increased persistence of diarrhea compared to Norovirus (OR = 3.5; 95% CI: 1.3-9.5; P = 0.02). Infection with Norovirus in children meant greater persistence of vomiting symptoms than infection with Campylobacter (P = 0.005), E. coli (P = 0.03), or if no pathogen was identified (P = 0.004). Adults usually vomited for fewer days than children while duration of diarrhea was similar to children. CONCLUSIONS: Many of the pathogens responsible for cases of gastroenteritis in the Australian community are likely to go undetected by current surveillance systems and routine clinical practice.

Adolescent↗
PubMed2004

An audit of obstetricians' management of women potentially infected with blood-borne viruses.

OBJECTIVE: To assess obstetricians' current antenatal screening practices for blood-borne viruses (hepatitis B, hepatitis C and HIV) and how they manage pregnant women infected with a blood-borne virus. DESIGN AND PARTICIPANTS: National cross-sectional survey conducted between September 2002 and January 2003. All obstetricians (n = 767) registered with the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) were mailed a questionnaire assessing their antenatal screening practices and knowledge of management of women potentially infected with a blood-borne virus. OUTCOME MEASURES: Concordance of clinical practice with RANZCOG recommendations and current evidence-based guidelines. RESULTS: 523 obstetricians (68% response rate) completed the questionnaire. Fifty-one per cent of respondents said they would always offer HIV screening and 60% would always offer HCV screening. For HIV-infected women, 36% of obstetricians would always recommend elective caesarean section and 33% would always avoid rupture of membranes. Despite a lack of evidence, 34% of obstetricians advise patients that the risk of HBV transmission is increased with breastfeeding, and 47% give the same advice about HCV transmission. CONCLUSION: There is some discordance between the RANZCOG antenatal screening recommendations for HCV and HIV and current practice. Knowledge about the management of HIV-infected women could be improved, and more obstetricians need to be aware that current evidence suggests there is no increased risk of transmission of HBV or HCV with breastfeeding.

Australia↗
PubMed2004

HIV and pregnancy in Australia.

It is estimated there are over 19 million women worldwide living with HIV infection. In Australia the total number of notified cases of HIV in women has been gradually increasing (the estimated number of women newly diagnosed with HIV infection was 78 in 2000 and 94 in 2001). Management of women in pregnancy and strategies to reduce perinatal transmission is critical, but differ significantly according to resource availability. The current review examines the best available scientific evidence and current guidelines for optimal management of HIV-infected women contemplating pregnancy in Australia.

Anti-HIV Agents↗
PubMed2004

Escherichia coli and community-acquired gastroenteritis, Melbourne, Australia.

As part of a study to determine the effects of water filtration on the incidence of community-acquired gastroenteritis in Melbourne, Australia, we examined fecal samples from patients with gastroenteritis and asymptomatic persons for diarrheagenic strains of Escherichia coli. Atypical strains of enteropathogenic E. coli (EPEC) were the most frequently identified pathogens of all bacterial, viral, and parasitic agents in patients with gastroenteritis. Moreover, atypical EPEC were more common in patients with gastroenteritis (89 [12.8%] of 696) than in asymptomatic persons (11 [2.3%] of 489, p < 0.0001). Twenty-two random isolates of atypical EPEC that were characterized further showed marked heterogeneity in terms of serotype, genetic subtype, and carriage of virulence-associated determinants. Apart from the surface protein, intimin, no virulence determinant or phenotype was uniformly present in atypical EPEC strains. This study shows that atypical EPEC are an important cause of gastroenteritis in Melbourne.

Bacterial Adhesion↗
PubMed2004

Food safety in family homes in Melbourne, Australia.

Poor food handling practices in the home are a likely cause of gastroenteritis. This study examined how often reported practices in Australian homes met public health food safety recommendations. During 1998 in Melbourne, Australia, food handling and food storage questionnaires were completed by an adult member in 524 and 515 families, respectively. Each family consisted of at least two adults and two children. Respondents were surveyed regarding washing of hands, cutting boards, and fresh produce; use of kitchen cloths; egg storage; where cooked foods were cooled; the duration before refrigeration of cooked foods; where food types were positioned in the refrigerator; and the method of thawing chicken. Nearly every household reported handling food in a way that could cause food to become contaminated. Overall, 99.0% of respondents reported some form of mishandling, which encompassed 70.3% who handled food preparation surfaces poorly, 46.6% who did not wash their hands appropriately or in a timely manner, 41.7% who mishandled raw foods, and 70.1% who mishandled cooked foods. Food was inappropriately located in the refrigerator by 81.2%, and chicken was thawed using unsafe means by 76.3% of respondents. People preparing food in the home need to be reminded of the increased risk of disease that can arise from poor food handling practices.

Adolescent↗
PubMed2003

Incidence and characteristics of endemic Norwalk-like virus-associated gastroenteritis.

Endemic gastroenteritis associated with the Norwalk-like viruses (NLVs) is little understood. This study tested for NLV in gastroenteritis cases in 257 households in Melbourne, Australia, for the period September 1997 to February 1999 by a reverse transcription hemi-nested polymerase chain reaction. Positive samples were studied by nucleotide sequencing and phylogenetic analysis. NLV was detected in 73 (11.4%) of 638 faecal specimens tested. Twelve (1.9%) were NLV genogroup 1 (G1) and 61 (9.6%) NLV genogroup 2 (G2). Gastroenteritis symptoms associated with NLV G2/no other pathogens were significantly more severe than where no NLV was detected. NLV G1 and NLV G2 were detected in adults and children, males and females. NLV G2 incidence showed a marked seasonal periodicity with significant peaks in the Australian late spring/early summer periods. NLV G1 seasonality was significantly different from that of NLV G2. Seven major NLV clusters were identified by phylogenetic analysis.

Adolescent↗
PubMed2003

Cost of community gastroenteritis.

BACKGROUND AND AIM: Gastroenteritis is a common illness that causes considerable morbidity in developed countries. Endemic gastroenteritis that is not associated with outbreaks causes the greatest number of cases, but information is limited about the burden of this disease, and the resources required to manage its impact on society. In the present study, we estimated the rate of endemic gastroenteritis, the number of visits to the local doctor, use of medication, and the cost of gastroenteritis in Australia. METHODS: Data from a community-based study of gastroenteritis, a general practice surveillance network, the Australian Bureau of Statistics and the Health Insurance Commission were used to measure endemic gastroenteritis and other study outcomes. The results were then extrapolated to the Australian Community. RESULTS: There were an estimated 0.8 cases of gastroenteritis per person per year in Australia. This equated to 15,173,430 cases of gastroenteritis in Australia annually. The age-standardized estimate of the total number of visits to the general practitioner (GP) for gastroenteritis was 1024,214 at a cost of 26,722,691 Australian dollars. The average cost of prescribed medication per visit was 6.83 Australia dollars; the estimated total cost of prescribed medication was 6995,381 Australian dollars. The estimated cost of over-the-counter medication was 14,587,477 Australia dollars. It was estimated that people working full or part-time had 0.13 days-off per person per year because of gastroenteritis, at a cost of 137,924,170 Australian dollars. The estimated total cost of endemic gastroenteritis in Australia was 342,855,616 Australian dollars of which 75,908,274 Australian dollars was direct medical costs and 266,947,342 Australian dollars was time costs and the costs for time off work to care for a sick family member. CONCLUSIONS: Endemic gastroenteritis is an important illness in both developed and developing countries. Although in developed countries, the majority of individual cases are mild to moderate in their severity; the overall costs are significant. The results highlight the need for ongoing research to identify the main causes of endemic gastroenteritis.

Adolescent↗
PubMed2003

A community-based study of respiratory episodes in Melbourne, Australia.

OBJECTIVE: To provide recent data regarding the epidemiology of community-based respiratory infections in Australia. METHODS: A longitudinal study between 1997-99 involving collection of a health diary from 600 families in Melbourne. RESULTS: More than 80% of study participants reported at least one respiratory episode over 15 months. An average of 2.2 respiratory episodes per person per year was reported, with a mean episode duration of 6.3 days. On average, subjects were symptomatic for 4.2% of the study days. Compared with other age groups, children aged less than two years were most likely to have at least one respiratory episode, a greater number of episodes per person and the longest episode duration (6.8 days). Approximately, one in three (28.7%) respiratory episodes were associated with a doctor's visit, and one in four (23%) necessitated time off school or work. Exposure to other people with respiratory symptoms was commonly reported. CONCLUSIONS: Respiratory infections are common, cause a significant amount of morbidity, and are major contributors to the total community health burden. IMPLICATIONS: The direct and indirect costs of respiratory infections to the community are substantial.

Adolescent↗