Biomedical subjects

Maria Gabriella Costa

Publications and source records attributed to Maria Gabriella Costa.

3 recordsLinked to original sources

PubMed2003

Preload indexes in thoracic anesthesia.

PURPOSE OF THE REVIEW: An adequate cardiac preload is essential in the treatment of critically ill patients. During anesthesia for thoracic surgery, volume and vasoactive therapy to optimize cardiac output, oxygen delivery (tissue perfusion) and to avoid pulmonary edema is a central therapeutic aspect. Cardiac preload has been estimated with different techniques in clinical practice, even though studies performed on thoracic anesthesia are lacking. RECENT FINDINGS: We analyze the conventional pulmonary artery catheter, transesophageal echocardiography and the transpulmonary indicator dilution technique as preload monitoring devices with their indications and limits in thoracic anesthesia. SUMMARY: The pulmonary artery catheter is confirmed as a fundamental device particularly in patients with pulmonary hypertension. For transesophageal echocardiography monitoring, the dependency on operator experience, the low repeatability and the high costs limit its interpretation and diffusion in clinical practice. During lung transplantation, Swan Ganz catheter monitoring is recommended. The optimization of fluid balance and vasoactive drug administration based on volumetric monitoring makes the transpulmonary indicator dilution technique a new option as an effective monitoring system during anesthesia for thoracic surgery when intravascular volume management is a primary objective.

Journal Article↗

PubMed2002

Severe reperfusion lung injury after double lung transplantation.

AIM: To demonstrate the effects of combined inhaled nitric oxide and surfactant replacement as treatment for acute respiratory distress syndrome. This treatment has not previously been documented for reperfusion injury after double lung transplantation. METHOD: A 24-year-old female with cystic fibrosis underwent double lung transplantation. During implantation of the second lung a marked increase in pulmonary artery pressure associated with systemic hypotension, hypoxemia and low cardiac output were observed. Notwithstanding the patient received support from cardiovascular drugs and pulmonary vasodilators cardiopulmonary by-pass was necessary. In the intensive care unit the patient received the same drug support, inhaled nitric oxide and two bronchoscopic applications of bovine surfactant. RESULTS: A rapid improvement in PaO2/FiO2 within 2-3 hours of administration of surfactant was seen. The patient is well at follow-up 1 year post-transplant. CONCLUSION: There is a potential role for a combined therapy with inhaled nitric oxide and surfactant replacement in reperfusion injury after lung transplantation.

Administration, Inhalation↗

PubMedDate not supplied

Cardiac output monitoring: aortic transpulmonary thermodilution and pulse contour analysis agree with standard thermodilution methods in patients undergoing lung transplantation.

PURPOSE: The PiCCO System is a relatively new device allowing intermittent cardiac output monitoring by aortic transpulmonary thermodilution technique (Aorta intermittent) and continuous cardiac output monitoring by pulse contour analysis (Aorta continuous). The objective of this study was to assess the level of agreement of Aorta intermittent and Aorta continuous with intermittent (PA intermittent) and continuous cardiac output (PA continuous) measured through a special pulmonary artery catheter (Vigilance System SvO(2)/CCO Monitor) in patients undergoing single- or double-lung transplantation. METHODS: Measurements were obtained in 58 patients: at four time points in patients undergoing single-lung transplantation and at six time points in those undergoing double-lung transplantation. Bland and Altman and correlation analyses were used for statistical evaluation. RESULTS: We found close agreement between the techniques. Mean bias between Aorta intermittent and PA intermittent and between Aorta continuous and PA continuous was 0.18 L x min(-1) (2SD of differences between methods = 1.59 L x min(-1)) and -0.07 L x min(-1) (2SD of differences between methods = 1.46 L x min(-1)) respectively. Mean bias between PA continuous and PA intermittent and Aorta continuous and PA intermittent was 0.15 L x min(-1) (2SD of differences between methods = 1.39 L x min(-1)) and 0.08 L x min(-1) (2SD of differences between methods = 1.43 L x min(-1)). CONCLUSION: Measurements with the aortic transpulmonary thermodilution technique give continuous and intermittent values that agree with the pulmonary thermodilution method which is still the current clinical standard.

Aorta↗