Biomedical subjects

Maria Larsson

Publications and source records attributed to Maria Larsson.

17 recordsLinked to original sources

PubMed2006

A supportive nursing care clinic: conceptions of patients with head and neck cancer.

Patients with head and neck cancer have complex long-lasting physical and psychosocial needs due to illness and treatment, and studies have shown deficiencies concerning support in these respects. The purpose of this study was to describe how head and neck cancer patients with eating problems conceived the significance of a supportive nursing care clinic before, during and after completion of radiotherapy. Thematic interviews were carried out in an open dialogue with 12 patients treated with radiotherapy for head and neck cancer. The phenomenologischer method was used in the analyses. The findings showed that the nurse clinic could meet head and neck cancer patients' needs of safety and security, which was especially important before and after completion of treatment when no other regular contacts in the health care system existed. The significance of the nurse clinic varied depending on where in the trajectory the patients were, what needs and problems they experienced, and how severe these were experienced by the individual patient. The supportive nursing care clinic could meet these patients' needs of knowledge, care and support both concerning practical measures related to the disease and its treatment, and emotional needs. This way of organising the care can contribute to these patients' health and wellbeing.

Aged↗

PubMed2006

Identification of unpleasant odors is independent of age.

The purpose of this study was to investigate (a) the relationship between identification proficiency for specific odors and chronological age and (b) to determine whether the relationships were related to perceived quality (i.e., judgments of familiarity, intensity, and hedonics) of the odor item. Data from 472 subjects (227 men, 245 women) ranging in age from 18 to 79 years were assessed in a cued identification test comprising 16 odors. The results indicated a reliable age effect in overall odor identification performance. Further analyses indicated that the observed age-related deficit was odorant-specific, with some odors being equally well identified across age cohorts and others showing sensitivity to the process of aging. Additional examination regarding the observed age-differential effects across the different odor types indicated that these may be understood according to the pleasantness/upleasantness associated with the odor. Specifically, odors perceived as unpleasant showed age invariance whereas odors rated as pleasant exhibited age sensitivity.

Adolescent↗

PubMed2006

Cognitive and social functioning in recovery from depression: results from a population-based three-year follow-up.

BACKGROUND: This study prospectively examined cognitive and social functioning in recovery from depression using participants sampled from the general population. METHOD: Seventy-six depressed persons fulfilling (n=41) and not fulfilling (n=35) the criteria for DSM-IV depression at a three-year follow-up were compared with respect to episodic memory performance and social functioning at baseline (T1), at follow-up (T2) and change across time. RESULTS: The groups did not differ in episodic memory performance either at T1, T2 or in residual change. However, the groups differed in social functioning at T2 and in residual change indicating improved social functioning in the recovered group. LIMITATION: The absence of a healthy control group at follow-up. CONCLUSION: Despite the symptomatic improvement and improved social functioning, cognitive functioning does not follow this general recovery trend, at least not in the three-year interval examined.

Adult↗

PubMed2006

What people believe about memory.

Two representative samples of adult Norwegians (n=2000) were asked a set of general and specific questions regarding their beliefs and opinions about human memory. The results indicate that on many questions, such as time of the earliest memories, inhibiting effects of collaboration, and memory for dramatic versus ordinary events, the views of the general public concurred with current research findings, and people in general had realistic views about their own memory performance. On other questions, such as the reliability of olfactory as compared with visual and auditory memory, the memory of small children in comparison with that of adults, the likelihood of repression of adult traumatic memories, and on more general questions such as the possibility of training memory and the capacity limitations of long-term memory, a large proportion of the participants expressed views that are less supported by scientific evidence. Implications of these findings are briefly discussed.

Adult↗

PubMed2006

Olfactory functions in asymptomatic carriers of the Huntington disease mutation.

Huntington's disease (HD) is a neurodegenerative disorder initially affecting the basal ganglia and especially the head of the caudate nucleus. Neuropsychological research has indicated that olfactory dysfunction may appear early in HD, prior to the onset of significant motor or cognitive dysfunction. The aim of this study was to examine whether asymptomatic carriers of the Huntington disease mutation also exhibit olfactory dysfunction. To address this issue we presented an extensive olfactory test battery comprising tasks assessing olfactory sensitivity, intensity discrimination, quality discrimination, episodic odor memory, and odor identification, to a group of gene carriers and nonmutation carriers of the disease. The results showed that gene carriers were selectively impaired in discriminating odor quality, although performance did not differ from noncarriers across the other tasks. The role played by striatum and then in particular the caudate nucleus for olfactory processing in general, and for odor quality discrimination in particular, is discussed.

Adult↗

PubMed2006

Kinesiophobia among patients with musculoskeletal pain in primary healthcare.

OBJECTIVES: To describe the occurrence of kinesiophobia and to investigate the association between kinesiphobia and pain variables, physical exercise measures and psychological characteristics in patients with musculoskeletal pain. DESIGN: A prospective descriptive study involving 2 selected physiotherapy departments within a primary healthcare setting in the south-west of Sweden. PATIENTS: Included were 140 of 369 (38%) consecutive patients (aged between 18 and 65 years) with musculoskeletal pain. METHODS: Questionnaires including background data, pain variables, physical exercise measures and psychological characteristics were sent to the patients prior to their appointment with the physiotherapist. A simple and a multiple logistic regression model were performed to identify associations among the variables where kinesiophobia was defined as the dependent variable. RESULTS: A high degree of kinesiophobia and psychological distress were observed in approximately 50% of the responders. According to the simple logistic regression analysis the factors that seemed to be associated with kinesiophobia were interference, disability, pain severity, pain intensity, life control, affective distress, depressed mood and solicitous response. The multiple logistic regression analysis showed no significant associations. CONCLUSION: Kinesiophobia is a commonly seen factor among patients with musculoskeletal pain, which ought to be taken into consideration when designing and performing rehabilitation programmes.

Adolescent↗

PubMed2006

Smell your way back to childhood: autobiographical odor memory.

This study addressed age distributions and experiential qualities of autobiographical memories evoked by different sensory cues. Ninety-three older adults were presented with one of three cue types (word, picture, or odor) and were asked to relate any autobiographical event for the given cue. The main aims were to explore whether (1) the age distribution of olfactory-evoked memories differs from memories cued by words and pictures and (2) the experiential qualities of the evoked memories vary over the different cues. The results showed that autobiographical memories triggered by olfactory information were older than memories associated with verbal and visual information. Specifically, most odor-cued memories were located to the first decade of life (<10 years), whereas memories associated with verbal and visual cues peaked in early adulthood (11-20 years). Also, odor-evoked memories were associated with stronger feelings of being brought back in time and had been thought of less often than memories evoked by verbal and visual information. This pattern of findings suggests that odor-evoked memories may be different from other memory experiences.

Age Factors↗

PubMed2005

Sex differentiated responses to intranasal trigeminal stimuli.

The aim of the study was to address sex-related hemispheric differences in trigeminal event-related potentials while controlling for the subjects' olfactory sensitivity. Event-related potentials to lateralized stimulation using the trigeminal stimulant CO(2) were recorded in 28 healthy young subjects (16 women). There was no sex-related difference in olfactory sensitivity. Results indicated a sex-differentiated response to trigeminally induced pain. Women were found to have generally higher amplitudes and shorter latencies of the late positive component than men. Moreover, men and women exhibited different hemispheric activations in that women expressed shorter latencies over the left hemisphere than men. The pronounced sex-related difference of the late positive component suggests a cognitive/emotional impact on the processing of intranasal pain as indicated by others.

Adult↗

PubMed2005

Neuropsychological functions in anxiety disorders in population-based samples: evidence of episodic memory dysfunction.

Most of the available evidence on neuropsychological functioning in anxiety disorders is based on clinical samples, investigating persons affected by obsessive-compulsive disorder. Knowledge is sparse regarding cognitive functions in other types of anxiety disorders. The aim of this study was to examine whether persons diagnosed with an anxiety disorder show neuropsychological impairments relative to healthy controls in tasks tapping episodic memory, verbal fluency, psychomotor speed, and executive functioning. Population-based samples comprising individuals affected by panic disorder with and without agoraphobia or agoraphobia (n=33), social phobia (n=32), generalised anxiety disorder (n=7), obsessive-compulsive disorder (n=16), and specific phobia (n=24) were compared with healthy controls (n=175) in test performance. Overall, the total anxiety disorder group exhibited significant impairments in episodic memory and executive functioning. Separate analyses on the respective anxiety subgroup indicated that panic disorder with and without agoraphobia, and obsessive-compulsive disorder were related to impairments in both episodic memory and executive functioning. In addition, social phobia was associated with episodic memory dysfunction. Verbal fluency and psychomotor speed were not affected by anxiety. Specific phobia and generalised anxiety disorder did not affect neuropsychological functioning.

Adult↗

PubMed2005

A history of diabetes is associated with an adverse outcome among patients admitted to hospital alive after an out-of-hospital cardiac arrest.

BACKGROUND: Factors of importance for the outcome among patients who are admitted to hospital alive after an out-of-hospital cardiac arrest are not well described in the literature. The importance of a history of diabetes for the outcome among these patients has not been reported in detail previously. This survey aims to describe the outcome among patients who were admitted to hospital after an out-of-hospital cardiac arrest in relation to whether they had a history of diabetes. METHODS: All patients who were admitted to hospital alive after an out-of-hospital cardiac arrest in the two city hospitals in the Municipality of Göteborg between 1980 and 2002 were included in the survey. RESULTS: In all, 1377 patients fulfilled the inclusion criteria and 187 (14%) of them had a history of diabetes. Patients with diabetes differed from those without diabetes by having a previous history of myocardial infarction, angina pectoris, hypertension and heart failure more frequently. Furthermore, they were older, with a mean age of 70 years versus 66 years for patients without diabetes. Among patients with diabetes, 25% were discharged alive, as compared with 37% of patients without diabetes (p=0.002). When adjusting for differences at baseline, the adjusted odds ratio for diabetic patients being discharged alive (versus no diabetes) was 0.57 (95% confidence interval, 0.39-0.80). CONCLUSION: Among patients admitted to hospital after an out-of-hospital cardiac arrest, 14% had a history of diabetes. These patients had a lower survival rate compared with those without diabetes, even after correcting for dissimilarities at baseline. It remains to be determined whether an early metabolic intervention in these patients will improve survival.

Age Distribution↗

PubMed2004

Recollective experience in odor recognition: influences of adult age and familiarity.

We examined recollective experience in odor memory as a function of age, intention to learn, and familiarity. Young and older adults studied a set of familiar and unfamiliar odors with incidental or intentional encoding instructions. At recognition, participants indicated whether their response was based on explicit recollection (remembering), a feeling of familiarity (knowing), or guessing. The results indicated no age-related differences in the distribution of experiential responses for unfamiliar odors. By contrast, for familiar odors the young demonstrated more explicit recollection than the older adults, who produced more "know" and "guess" responses. Intention to learn was unrelated to recollective experience. In addition, the observed age differences in "remember" responses for familiar odors were eliminated when odor naming was statistically controlled. This suggests that age-related deficits in activating specific odor knowledge (i.e., odor names) play an important role for age differences in recollective experience of olfactory information.

Adolescent↗

PubMed2004

Demographic and cognitive predictors of cued odor identification: evidence from a population-based study.

This study investigated demographic and cognitive correlates of cued odor identification in a population-based sample from the Betula project: 1906 healthy adults varying in age from 45 to 90 years were assessed in a number of tasks tapping various cognitive domains, including cognitive speed, semantic memory and executive functioning. The results revealed a gradual and linear deterioration in cued odor identification across the adult life span. Overall, females identified more odors than men, although men and women performed at the same level in the oldest age cohort (85-90 years). Hierarchical regression analyses revealed that age, sex, education, cognitive speed and vocabulary were reliable correlates of performance in the odor identification task. In addition, age-related deficits in the included demographic and cognitive variables could not fully account for the observed age-related impairment in identification, suggesting that additional factors are underlying the observed deterioration. Likely candidates here are sensory abilities such as olfactory detection and discrimination.

Adult↗

PubMed2003

Depth of olfactory sulcus and olfactory function.

The aim of this study was to identify whether the depth of the olfactory sulcus relates to olfactory function in healthy subjects. Forty-four healthy, male volunteers (age range 22-45 years, mean age 28.3 years) were included in this study. Olfactory function was measured for phenyl ethyl alcohol odor thresholds, odor discrimination, and odor identification. Magnetic resonance imaging of the olfactory sulcus was performed immediately following olfactometry. Based on previous investigations the depth of the olfactory sulcus was measured in the plane of the posterior tangent through the eyeballs. Olfactory function correlated significantly with left-sided depth of the olfactory sulcus (r(44)=0.33, P=0.03); no such correlation was seen for the right side. In addition, olfactory sulcus depth was found to be significantly deeper on the right compared to the left side (t=5.61, P<0.001). The present results suggest that there is small, but significant relation between morphological brain structures and measures of olfactory function. Further, lateralization of olfactory sulcus depth may correlate to functional lateralization in the olfactory system. Thus, it may be carefully speculated that sensory input in the olfactory system results in cortical growth in the area of the olfactory sulcus, at least at some developmental stage.

Adult↗

PubMed2003

Sex differences in recollective experience for olfactory and verbal information.

We examined recollective experience as a function of sex for olfactory and verbal information. In the first study, men and women studied a set of highly familiar odors with incidental or intentional encoding instructions. In the second study, participants were presented with a number of sentences. At recognition, participants indicated whether their positive response was based on conscious recollection (remembering), a feeling of familiarity (knowing), or guessing. The results indicated that recollection was higher among women than men, and that familiarity-based recognition was equally large across sex for both types of information.The finding that the sex-related experiential difference disappeared when controlling for verbal proficiency suggests that sex-related differences in activating verbal information play an important role for sex differences in recollective experience.

Adult↗

PubMed2003

Lived experiences of eating problems for patients with head and neck cancer during radiotherapy.

Only a small proportion of cancer patients undergo radical radiotherapy to the head and neck, but their needs are particularly complex. Although extensive research describes the side-effects of radiotherapy to the head and neck, few studies focus on patients' subjective experiences of eating problems and the impact these have on the patients' daily life. In this study a phenomenological approach was used, as the purpose was to acquire deeper understanding of head and neck cancer patients' lived experiences of eating problems, their consequences in daily life and patients' strategies of coping with these problems. Eight patients from two radiation therapy departments in mid-Sweden were interviewed in an open dialogue. Data analysis was based on Colaizzi's method. Eating problems experienced were captured in two interrelated main themes: "Ability to chew and swallow" and "Will and desire to eat". The eating problems were found to cause a number of severe consequences in daily life. These are incorporated into one main theme: "The way of life is disturbed". Ways to cope with this disturbance were captured in one main theme: "Trying to see the end - To survive". This study identifies the need to view eating problems as a complex phenomenon in a specific context including the individual patient's life situation. The findings create the opportunity to develop nursing interventions based on patients' own needs. To facilitate this, a specialist nurse should be responsible for reviewing patients regularly throughout radiation therapy. Intervention studies are needed to provide optimal clinical guidelines.

Adaptation, Physiological↗

PubMed2002

Differential sex effects in olfactory functioning: the role of verbal processing.

We investigated sex difference across a number of olfactory tasks. Thirty-six men and 35 women ranging in age from 19 to 36 years were assessed in 6 different tasks: absolute sensitivity for n-butanol, intensity discrimination, quality discrimination, episodic recognition memory for familiar and unfamiliar odors, and odor identification. No sex differences were observed in the tasks tapping primarily sensory acuity (i.e., odor sensitivity, intensity discrimination, and quality discrimination) or in episodic memory for unfamiliar odors. By contrast, women outperformed men in the tasks involving verbal processing (i.e., memory for familiar odors and odor identification). Interestingly, controlling for odor naming ability resulted in that the observed sex difference in episodic odor memory for familiar odors disappeared. This outcome suggests that women's superiority in episodic odor memory is largely mediated by their higher proficiency in odor identification.

Adult↗

PubMedDate not supplied

Eating problems and weight loss for patients with head and neck cancer: a chart review from diagnosis until one year after treatment.

This descriptive study aimed to examine the occurrence and treatment of eating problems, and their causes and consequences during the trajectory of care for patients with head and neck cancer treated with radiotherapy. The method used was a review of patient records, conducted by means of an audit instrument developed for the study. The instrument audits demographic data and documented eating problems, their causes and consequences, and undertaken interventions in medical and nursing records from diagnosis until 1 year after completion of treatment. Data were collected prior to treatment, each week during radiotherapy and at the follow-up visits to the physician 1, 6, and 12 months after completion of treatment. The results show that eating problems were common before treatment started, and at the end of radiotherapy every patient suffered from eating problems. One year after treatment the majority still had eating problems. Weight loss occurred early during radiotherapy and became aggravated after treatment, but was not treated to an adequate extent. Implications of this study are that nutritional interventions must be initiated before the treatment starts and they need to be ongoing after completion of treatment.

Adult↗