PubMed Health⌕ Search

Biomedical subjects

Maria Papageorge

Publications and source records attributed to Maria Papageorge.

4 recordsLinked to original sources
PubMed2005

Mandibular distraction osteogenesis: a rabbit model using a novel experimental design.

PURPOSE: Distraction osteogenesis (DO) is a surgical procedure that targets bone regeneration and elongation, currently used in the treatment of many craniofacial deformities. The quest for optimization of DO clinical parameters has led to the development of a variety of animal models. Our study aims to establish a rabbit animal model of mandibular DO, in which the control osteotomy and distraction device are placed on the opposite hemimandible from the one being distracted, within the same animal host. Furthermore, we propose to histologically characterize the different stages or distraction and consolidation in the same animal model. MATERIALS AND METHODS: Twenty-five rabbits underwent mandibular osteotomies and bilateral placement of distraction devices. After a latency of 3 days, the distraction device was activated on one side of each animal at a rate of 0.5 mm/12 hours for 7 days, while the other side remained inactive (control). This was followed by a consolidation period of 14 days. Five animals per time-point were killed on days 3, 7, 10, 17, and 24. RESULTS: Gross tissue analysis showed a 7-mm callus formation at the distracted side and a well-healed osteotomy in the non-distracted side. Clinically, a unilateral Class III malocclusion occurred in the distracted side. Histology at each time-point shows new bone formation and orientation of the bony spicules along the axis of the mechanical strain. CONCLUSIONS: We have established and characterized an animal model of mandibular DO that outlines valid biologic controls and provides thorough monitoring of the DO process.

Animals↗
PubMed2002

Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen.

Ibuprofen is a safe and effective analgesic, but some formulations have a slow onset of action. Ibuprofen arginate is a rapidly absorbed salt designed to promote more rapid onset of analgesia. A clinical trial was conducted in 226 patients with postoperative dental pain to assess the analgesic efficacy and speed of onset of the arginine salt of ibuprofen compared with one of the commercially available forms of ibuprofen. Patients were administered a single dose of either ibuprofen arginate (200 mg or 400 mg), ibuprofen (200 mg or 400 mg), or placebo in this double-blind, randomized trial. To determine the onset of action of the study medication patients were required to note time to "any" pain relief and then time to "meaningful" pain relief, using the two-stopwatch method. Pain intensity and relief were assessed using traditional categorical scales over a 6-h period. Meaningful pain relief was achieved in 42 min and 24 min for ibuprofen arginate 200 mg and 400 mg, respectively, compared with 50 min and 48 min for ibuprofen 200 mg and 400 mg, respectively ( P<0.05). The results for the measurements of analgesic effectiveness [sum of pain intensity difference, total pain relief (TOTPAR), peak pain relief and overall evaluation of treatment] all showed that both doses of ibuprofen arginate and both doses of ibuprofen were significantly better than placebo and both 200-mg and 400-mg ibuprofen arginate doses were significantly better than ibuprofen 200 mg for peak pain relief. Mean plasma ibuprofen concentrations at 30 min and 60 min, respectively, were: ibuprofen arginine 200 mg, 13.9 micro g/ml and 15.7 micro g/ml; ibuprofen arginine 400 mg, 29.5 micro g/ml and 29.3 micro g/ml; ibuprofen 200 mg 2.5 micro g/ml and 5 micro g/ml; ibuprofen 400 mg, 2.3 micro g/ml and 7.4 micro g/ml. ( P<0.05). Adverse event profiles were similar across treatment groups. These results overall suggest that ibuprofen arginate when taken at doses equivalent to commercially available ibuprofen formulations produces analgesia that is faster in onset.

Adult↗