Biomedical subjects

Marianna Vlychou

Publications and source records attributed to Marianna Vlychou.

4 recordsLinked to original sources

PubMed2006

Osteoid osteoma.

Osteoid osteoma is a relatively frequent benign bone tumour, consisting of osteoid and woven bone, and surrounded by a halo of reactive sclerotic bone, with an average size of the nidus less than 1.5 cm. It is a condition of late childhood, adolescence and young adult age. It usually occurs in the appendicular skeleton and the spine, and is generally localised in or near the cortex. The lesion causes pain, especially at night, but can cause joint pain with synovitis and joint effusion if located in the vicinity of chondral structures, or painful scoliosis if located in the spine. Osteoid osteoma may have an unpredictable course, and may require treatment or resolve spontaneously. In some cases, the diagnostic approach is challenging; there are different treatment methods, some of which have been recently introduced, with promising results. We review the literature about the natural history, clinical presentation, diagnostic approach and classical or modern treatment modalities of osteoid osteoma.

Adolescent↗

PubMed2006

Echo-Doppler measurements of portal vein and hepatic artery in asymptomatic patients with hepatitis B virus and healthy adults.

BACKGROUND AND AIM: The aim of this prospective study was to determine the range of various hemodynamic parameters of portal vein and hepatic artery with echo-Doppler imaging in asymptomatic carriers of hepatitis B virus (HBV) and healthy adults. METHODS: One hundred and twenty two healthy adults and fifty-three asymptomatic patients with chronic HBV formed two groups. All participants underwent color Doppler imaging of the portal vein and hepatic artery. A single operator performed all echo-Doppler measurements. The examination protocol included measurements of portal vein and hepatic artery diameter (d), blood flow (BF), time averaged velocity (TAV) and calculation of Doppler Perfusion Index (DPI) of liver. RESULTS: Asymptomatic HBV carriers showed a statistically significant decrease in portal vein TAV (12.8 ± 6.1 vs 17.5 ± 8.8), an increase in portal vein BF (411.38 ± 211.31 vs 327.55 ± 188.77) and decrease in DPI (0.18 ± 0.14 vs 0.28 ± 0.15). CONCLUSIONS: Echo-Doppler measurements of portal vein and hepatic artery can detect significant hemodynamic changes in asymptomatic HBV carriers.

Adult↗

PubMed2003

Angiographic findings and clinical implications of persistent primitive hypoglossal artery.

BACKGROUND: The primitive hypoglossal artery (PHA) is a rare vascular anomaly, which belongs to the group of carotid-basilar anastomosis that may occur in adults. CASE PRESENTATION: Herein is presented a case of a patient with a PHA, who had undergone a cerebral angiography due to investigation of subarachnoid hemorrhage. Additionally, the diagnostic alternatives for detection and assessment of PHA and the spectrum of diseases related to its presence are discussed. CONCLUSIONS: The presence of a persistent PHA can be recognized as an incidental finding in a cerebral angiography without any other clinical implication or may be associated with certain clinical entities such as aneurysm formation and atherosclerotic disease.

Journal Article↗

PubMedDate not supplied

Primary lymphomas of bone.

Primary lymphomas of bone are uncommon malignancies. The vast majority of them are non-Hodgkin lymphoma (NHL), whereas primary Hodgkin lymphoma (HL) of bone is extremely rare. Patients with primary NHL of bone commonly present with local bone pain, soft tissue swelling, and a mass or a pathological fracture. There is a slight male preponderance, and most patients are over 45-50 years of age. Primary NHL of bone can arise in any part of the skeleton, but long bones (femurs, tibia) are the most common sites of presentation. Comprehensive immunohistochemical studies are required to establish an accurate histological diagnosis of primary NHL of bone. Most cases of primary NHL of bone are classified as diffuse large B-cell lymphomas (DLBCL) in the World Health Organisation (WHO) classification of hematological malignancies. On full staging evaluation, most patients have disease of stage IE or IIE according to the Ann Arbor system. Several studies indicate that patients with primary NHL of bone have a favorable outcome, especially when treated by combined modality therapy. A number of studies reported that clinical stage is the most important prognostic variable in predicting overall survival. Interestingly, the rare occurrence of primary lymphoma of bone is in contrast with the frequency of plasma cell tumors in bone. This could be due to the fact that, during normal B-cell differentiation, the bone marrow is the normal site of homing of plasma cells which are terminally-differentiated, immunoglobulin-secreting post-germinal center B-cells. In this respect, there is circumstancial evidence that primary NHL of bone may represent tumors of post-germinal center B-cells. The present review summarizes data on the histogenesis of primary NHL of bone in view of the recent histogenetic classification of DLBCL on the basis of the B-cell differentiation gene expression profiles (germinal center vs. post-germinal center B-cell differentiation).

Bone Neoplasms↗