Biomedical subjects

Marie Andersen

Publications and source records attributed to Marie Andersen.

2 recordsLinked to original sources

PubMed2006

Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines.

Although clinical trials with GLP-2 receptor agonists are currently ongoing, the mechanisms behind GLP-2-induced intestinal epithelial growth remain to be understood. To approach the GLP-2 mechanism of action this study aimed to identify intestinal cell lines endogenously expressing the GLP-2 receptor. Here we report the first identification of a cell line endogenously expressing functional GLP-2 receptors. The human intestinal epithelial cell line, FHC, expressed GLP-2 receptor encoding mRNA (RT-PCR) and GLP-2 receptor protein (Western blot). In cultured FHC cells, GLP-2 induced concentration dependent cAMP accumulation (pEC(50)=9.7+/-0.04 (mean+/-S.E.M., n=4)). In addition, a naturally occurring human intestinal fibroblast cell line, 18Co, endogenously expressing GLP-2 receptor encoding mRNA (RT-PCR) and protein (Western blot) was identified. No receptor functionality (binding or G-protein signalling) could be demonstrated in 18Co cells. The identified gut-relevant cell lines provide tools for future clarification of the mechanisms underlying GLP-2-induced epithelial growth.

Animals↗

PubMed2003

Facial image identification using Photomodeler.

We present the results of a preliminary study on the use of 3-D software (Photomodeler) for identification purposes. Perpetrators may be photographed or filmed by surveillance systems. The police may wish to have these images compared to photographs of suspects. The surveillance imagery will often consist of many images of the same person taken from different angles. We wanted to see if it was possible to combine such a suite of images in useful 3-D renderings of facial proportions.Fifteen male adults were photographed from four different angles. Based on these photographs, a 3-D wireframe model was produced by Photomodeler. The wireframe models were then rotated to full lateral and frontal views, and compared to like sets of photographs of the subjects. In blind trials, 9/15 of the wireframe models were assigned to the correct sets of photographs. In five/15 cases, the wireframe models were assigned to several sets, including the correct set. Only in one case was a wireframe model not assigned to a correct set of photographs at all.

Face↗