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Mario Rüdiger

Publications and source records attributed to Mario Rüdiger.

21 records · Page 2Linked to original sources

[Integrating problem-based learning into traditional medical courses: the PBL approach to Pediatrics in Berlin].

Integrating a problem-based learning (PBL) approach into the classical curriculum for medical students is often considered difficult because of fundamental differences in the two teaching methods. At the Charité, the medical school of Berlin's Humboldt University, students with a regular medical curriculum are offered to choose between a regular and a PBL class for their course in Paediatrics. During the three-week course in PBL Paediatrics medical students spend the morning in different clinics of the "Otto Heubner Centre for Paediatrics". They are strongly involved in the medical care of 3-4 patients with typical paediatric diseases. Each afternoon, one of the students presents a patient. Patient problems are discussed according to the seven steps of PBL. Subsequently, students use different tools and sources through self-studies to obtain information on the specific disease. By integrating the principles of "Evidence-based medicine" students are trained to critically appraise the medical literature. At the end of the course students are asked to evaluate the quality of the medical teacher, thus allowing for continuous improvement of the teaching methods. We conclude that the principles of PBL can be integrated into a conventional curriculum in medical school.

Berlin↗

Effect of cholesterol and surfactant protein B on the viscosity of phospholipid mixtures.

Low viscosity of the surface of alveolar fluid is mandatory for undisturbed surfactant function. Based on the known reduction of the viscosity of surfactant-like phospholipid (PL-) mixtures by plasmalogens, the effect of cholesterol and surfactant protein (SP-) B on surface viscosity of these lipid mixtures has been studied. Surface viscosity at the corresponding surface tension was measured with the oscillating drop surfactometer. We found that the viscosity was lowest in cholesterol-, followed by plasmalogen- and SP-B containing samples. Addition of SP-B to a plasmalogen-containing PL-mixture caused a further decrease in viscosity. However, in cholesterol containing mixtures, addition of SP-B led to a significant increase in viscosity, and the effect was reversed by further addition of plasmalogens. We conclude that SP-B, plasmalogens and cholesterol all affect the surface viscosity, thus synergistically regulate monolayer stability. This suggests that they are all needed in vivo for fine tuning of surface properties of pulmonary surfactant.

Animals↗

Cerebral oxygenation is affected by filling mode and perfluorochemical volume in partial liquid ventilation of healthy piglets.

Intrapulmonary administration of perfluorochemicals (PFC) has been suggested for reasons other than respiratory insufficiency. PFC application has been described to affect cerebral Hb concentration, however, data for healthy lungs are missing. Newborn piglets were randomized into 3 groups (30-ml slow-filling, 10-ml slow-filling and 30-ml rapid-filling), orally intubated and mechanically ventilated. Partial liquid ventilation (PLV) was initiated by filling the lung with PF5080 (10 or 30 ml/kg) at a rate of 1.5 ml/min (slow filling) or within 45 s (rapid filling). Vital signs, blood gases, tidal volume (VT) and changes in the cerebral concentration of oxygenated hemoglobin (HbO(2)) and total Hb were determined for up to 20 min. Rapid administration of PFC caused an immediate drop in HbO(2), PaO(2) and VT. The concentration of oxygenated and total Hb increased thereafter and remained high. We found a slow increase in PaCO(2), HbO(2) and total Hb in the 30-ml slow-filling group, but almost no changes in the 10-ml slow filling group (except for a decrease in PaO(2)). According to our data, PLV with 10 ml/kg should be preferred since cerebral alterations are minimal. If complete filling of the lung is needed PFC should be administered slowly to minimize side effects.

Animals↗