Calcium and stunning: when, from where, and what next?
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Actin Cytoskeleton↗
Biomedical subjects
Mark E Anderson
Publications and source records attributed to Mark E Anderson.
Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management.
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Action Potentials↗
Cardiac ion channels.
The normal electrophysiologic behavior of the heart is determined by ordered propagation of excitatory stimuli that result in rapid depolarization and slow repolarization, thereby generating action potentials in individual myocytes. Abnormalities of impulse generation, propagation, or the duration and configuration of individual cardiac action potentials form the basis of disorders of cardiac rhythm, a continuing major public health problem for which available drugs are incompletetly effective and often dangerous. The integrated activity of specific ionic currents generates action potentials, and the genes whose expression results in the molecular components underlying individual ion currents in heart have been cloned. This review discusses these new tools and how their application to the problem of arrhythmias is generating new mechanistic insights to identify patients at risk for this condition and developing improved antiarrhythmic therapies.
Animals↗
High-grade uveal B-cell lymphoma as the initial feature in Richter syndrome.
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Aged↗
Impoverished children with asthma: a pilot study of urban healthcare access.
ISSUES AND PURPOSE: Using Andersen's Behavioral Model of Health Care Use, this pilot study was conducted to better understand the experiences of children with asthma as they access an urban healthcare system. DESIGN AND METHODS: This descriptive study used a convenience sample of 34 families of pediatric asthma patients who participated in semistructured interviews and closed medical record review. RESULTS: Only one patient reported having a written exacerbation management plan. Beliefs regarding medication addiction and side effects were frequently reported as barriers to medication adherence, and children seeking asthma care in primary care settings saw many care providers. PRACTICE IMPLICATIONS: Exploring how expanded nursing roles can help address both family and system factors serving as barriers to health care ought to be a key priority for nursing.
Adolescent↗