Biomedical subjects

Mark W Powell

Publications and source records attributed to Mark W Powell.

4 recordsLinked to original sources

PubMed2005

Reversal of diabetic peripheral neuropathy with phototherapy (MIRE) decreases falls and the fear of falling and improves activities of daily living in seniors.

OBJECTIVE: to determine whether restoration of sensation, impaired due to diabetic peripheral neuropathy (DPN), would reduce the number of falls and the fear of falling and improve activities of daily living (ADL) in a Medicare-aged population. DESIGN: retrospective cohort study of patients with documented, monochromatic near-infrared phototherapy (MIRE)-mediated, symptomatic reversal of DPN. SETTING: responses to a health status questionnaire following symptomatic reversal of DPN. PATIENTS: 252 patients (mean age 76 years) provided health information following symptomatic reversal of diabetic neuropathy (mean duration 8.6 months). MAIN RESULTS: incidence of falls and fear of falling decreased within 1 month after reversal of peripheral neuropathy and remained low after 1 year. Likewise, improved ADL were evident soon after reversal of peripheral neuropathy and showed further improvement after 1 year. Overall, reversal of peripheral neuropathy in a clinician's office and subsequent use of MIRE at home was associated with a 78% reduction in falls, a 79% decrease in balance-related fear of falling and a 72% increase in ADL (P < 0.0002 for all results). CONCLUSIONS: reversal of peripheral neuropathy is associated with an immediate reduction in the absolute number of falls, a reduced fear of falling and improved ADL. These results suggest that symptomatic reversal of diabetic neuropathy will have a substantial favourable, long-term socioeconomic impact on patients with DPN and the Medicare system, and improve the quality of life for elderly patients with diabetes and peripheral neuropathy.

Accidental Falls↗

PubMed2004

A methodology for extracting objective color from images.

We present a methodology for correcting color images taken in practical indoor environments, such as laboratories, factories, and studios, that explicitly models illuminant location, surface reflectance and geometry, and camera responsivity. We explicitly model surfaces by taking our color images with corresponding registered three-dimensional (3-D) range images, which provide surface orientation and location information for every point in the scene. We automatically detect regions where color correction should not be applied, such as specularities, coarse texture regions, and jump edges. This correction results in objective color measures of the imaged surfaces. This kind of integrated, comprehensive system of color correction has not existed until now. i.e., it is the first of its kind in computer vision. We demonstrate results of applying this methodology to real images for applications in photorealistic rerendering, skin lesion detection, burn scar color measurement, and general color image enhancement. We also have tested the method under different lighting configurations and with three different range scanners.

Algorithms↗

PubMed2002

Simultaneous determination of ibuprofen and hydroxypropylmethylcellulose (HPMC) using HPLC and evaporative light scattering detection.

Ibuprofen may be crystallised in the presence of hydroxypropylmethylcellulose (HPMC) to improve its physical properties. This, however, creates problems with the simultaneous analysis of each ingredient. The analytical method developed utilised high performance liquid chromatography (HPLC) with a stationary phase designed for carbohydrate separation (GylcoSep N) and a mobile phase comprising methanol and water. Evaporative light scattering detection (ELSD) proved a suitable method for the analysis of both HPMC and ibuprofen. Data showed that HPMC and ibuprofen could be quantified in each other's presence. Validation studies indicated that the method was adequately accurate and precise. Baseline resolution was achieved between the two components. HPMC (1.1% w/w) was retained in ibuprofen crystals obtained from alcoholic HPMC suspensions.

Chromatography, High Pressure Liquid↗

PubMedDate not supplied

Reversal of diabetic peripheral neuropathy and new wound incidence: the role of MIRE.

OBJECTIVE: To determine if improved foot sensitivity to the Semmes-Weinstein 10-g (5.07) monofilament, originally impaired because of diabetic peripheral neuropathy, might be associated with a reduced incidence of new diabetic foot wounds. DESIGN: Retrospective cohort study using a health status questionnaire. SUBJECTS: Sixty-eight individuals over age 64 with diabetes, diabetic peripheral neuropathy, and loss of protective sensation who had clinically demonstrable increases in foot sensation to the Semmes-Weinstein monofilament after treatment with monochromatic near infrared photo energy. MAIN RESULTS: After reversal of diabetic peripheral neuropathy following treatment with monochromatic near infrared photo energy, only 1 of 68 patients developed a new diabetic foot wound, for an incidence of 1.5%. Comparatively, the incidence previously reported in the Medicare-aged population with diabetes was 7.3%. CONCLUSIONS: Improved foot sensitivity to the Semmes-Weinstein monofilament in patients previously suffering from loss of protective sensation due to diabetic neuropathy appears to be associated with a lower incidence of new diabetic foot ulcers when compared with the expected incidence in the Medicare-aged population with diabetes. CLINICAL RELEVANCE: Therapeutic interventions that effectively improve foot sensitivity that has been previously diminished due to diabetic peripheral neuropathy may substantially reduce the incidence of new foot wounds in the Medicare-aged population with diabetes.

Aged↗