Biomedical subjects

Markus Zahn

Publications and source records attributed to Markus Zahn.

3 recordsLinked to original sources

PubMed2006

Magnetoviscosity in suspensions of grains with finite magnetic anisotropy.

Coupling between magnetic and mechanical rotational degrees of freedom of fine ferromagnetic grains is provided by the energy of their magnetic anisotropy. In the limiting case of strong anisotropy, an applied stationary magnetic field induces the greatest obstacles to the "rigid dipole" spin in a vortex ferrofluid flow, while in the opposite ideal case, the "soft dipoles" twist freely with the liquid. As a result, the field-dependent part of the ferrofluids viscosity depends not only on the external magnetic field strength but also on the particle magnetic anisotropy. An explicit expression coming from simple physical arguments and describing both these dependencies of magnetoviscosity is derived and discussed.

Journal Article↗

PubMed2006

Transcranial magnetic stimulation and stroke: a computer-based human model study.

This paper explores how transcranial magnetic stimulation (TMS) induced currents in the brain are perturbed by electrical and anatomical changes following a stroke in its chronic stage. Multiple MRI derived finite element head models were constructed and evaluated to address the effects that strokes can have on the induced stimulating TMS currents by comparing stroke models of various sizes and geometries to a healthy head model under a number of stimulation conditions. The TMS induced currents were significantly altered for stimulation proximal to the lesion site in all of the models analyzed. The current density distributions were modified in magnitude, location, and orientation such that the population of neural elements that are stimulated will be correspondingly altered. The current perturbations were minimized for conditions tested where the coil was far removed from the lesion site, including models of stimulation contralateral to the lesioned hemisphere. The present limitations of TMS to the peri-lesional cortex are explored, ultimately concluding that conventional clinical standards for stimulation are unreliable and potentially dangerous predictors of the site and degree of stimulation when TMS is applied proximal to infarction site.

Computer Simulation↗

PubMed2004

Three-dimensional head model simulation of transcranial magnetic stimulation.

This paper presents a finite element method used to evaluate the induced current density in a realistic model of the human head exposed to a time varying magnetic field. The tissue electric properties were varied to ascertain their influence on the induced currents. Current density magnitude and vector plots were generated throughout the tissue layers to determine the effects of tissue boundaries on the field. The current density magnitude correlated to the conductivity of the tissue in all the cases tested except where the tissue permittivity was raised to a level to allow for displacement currents. In this case, the permittivity of the tissue was the dominant factor. Current density components normal to the tissue interface were shown to exist in all solutions within the cortex contrary to the predictions of present models that rely on symmetrical geometries. Additionally, modifications in the cortical geometry were shown to perturb the field so that the site of activation could be altered in diseased patient populations. Finally, by varying the tissue permittivity values and the source frequency, we tested the effects of alpha dispersion theories on transcranial magnetic stimulation.

Adult↗