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Biomedical subjects

Martha Merrow

Publications and source records attributed to Martha Merrow.

5 recordsLinked to original sources
PubMed2002

Light reception and circadian behavior in 'blind' and 'clock-less' mutants of Neurospora crassa.

The filamentous fungus Neurospora crassa is a model organism for the genetic dissection of blue light photoreception and circadian rhythms. WHITE COLLAR-1 (WC-1) and WC-2 are considered necessary for all light responses, while FREQUENCY (FRQ) is required for light-regulated asexual development (conidia formation); without any of the three, self-sustained (circadian) rhythmicity in constant conditions fails. Here we show that light-regulated and self-sustained development occur in the individual or mutant white collar strains. These strains resemble wild type in their organization of the daily bout of light-regulated conidiation. Molecular profiles of light- induced genes indicate that the individual white collar-1 and white collar-2 mutants utilize distinct pathways, despite their similar appearance in all aspects. Titration of fluence rate also demonstrates different light sensitivities between the two strains. The data require the existence of an as-yet-unidentified photoreceptor. Furthermore, the extant circadian clock machinery in these mutant strains supports the notion that the circadian system in Neurospora involves components outside the WC-FRQ loop.

Base Sequence↗
PubMed2002

"What watch?...such much!" Complexity and evolution of circadian clocks.

This review uses three examples to summarise our knowledge about the complexity and the evolution of circadian systems. The first example describes the ecology of unicellular algae, which use their circadian system to optimise the daily exploitation of resources that are spatially separated. The second example looks at the role of clocks in tissues and cells within a complex organism, and the third speculates on how the circadian system may have evolved.

Animals↗
PubMed2002

Light reception: discovering the clock-eye in mammals.

Light is the most reliable environmental signal for adjusting biological clocks to the 24-hour day. Mammals receive this signal exclusively through the eyes, but not just via rods and cones. New evidence has been uncovered for a novel photoreceptor that may be responsible for more than just adjusting the clock.

Animals↗
PubMed2002

Life before the clock: modeling circadian evolution.

A feedback loop that functions via transcription and translation is thought to be the mechanistic core of circadian rhythmicity. Numerous modeling efforts incorporate the identified components and their modifications to recreate the circadian clock in computer simulations. Several issues remain problematic, including the lack of precise quantitative kinetics and the likely existence of additional, as-yet-undiscovered components. Even without these complications, models and flow charts of the circadian system have reached high complexity. They attempt to reconcile all observations without violating current views and concepts. In this article, the authors consider the mechanisms that may have preceded the circadian system in evolution. Given that cellular metabolism and biochemistry were presumably already interconnected in cascading feedback reactions prior to the appendage of the transcription/translation feedback loop, a coordinated response to exogenous changes would be advantageous over unsystematic responses. The authors hypothesize that those mechanisms that allowed synchronization in spite of metabolic complexity form the basis for the evolution of circadian properties and are as fundamental to the circadian system as the transcriptional/translational feedback loop.

Animals↗