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Martin Desrosiers

Publications and source records attributed to Martin Desrosiers.

4 recordsLinked to original sources
PubMed2003

Evidence-based endoscopic sinus surgery.

Evidence-based medicine principles applied to otolaryngology and endoscopic sinus surgery provide the surgeon, patient, and third-party payer with all of the necessary requirements to evaluate the effectiveness of the surgery. Above all, they ensure long-term improvement in quality of life and patients' satisfaction. A specific study on the outcomes of endoscopic sinus surgery is presented. A longitudinal observational study of 51 patients undergoing endoscopic sinus surgery for recurrent acute rhinosinusitis, chronic rhinosinusitis, and nasal polyposis was done in two hospitals. Patients were evaluated preoperatively and 3 months postoperatively with a disease-specific health status questionnaire (Quebec French-Rhinosinusitis Outcome Measure) and a general health status questionnaire (the Medical Outcome Study 36-Item Short-Form Health Survey). The results show statistically significant improvement in quality of life after endoscopic sinus surgery in both the disease-specific and the disease-generic health status questionnaires. The broader subject of objective and subjective outcomes assessment, along with evidence-based evaluation, is discussed.

Adult↗
PubMed2002

Cytokine profile of chronic sinusitis in patients with cystic fibrosis.

BACKGROUND: The inflammatory-cell and cytokine profiles of chronic sinusitis (CS) are well documented in the literature. In contrast, little is known about the pathogenesis of this condition in patients with cystic fibrosis (CF). OBJECTIVE: To determine whether patients with CF have inflammatory-cell and cytokine profiles that differ from other patients with CS. METHODS: Patients with CF (n = 7) and adults with CS (n = 7) undergoing functional endoscopic sinus surgery were recruited for the study. Patients with no allergies or sinus disease (n = 6) were used as controls. Using immunohistochemical analysis, we assessed sinus mucosal specimens for the presence of T lymphocytes, eosinophils, macrophages, and neutrophils. Using in situ hybridization, we assessed the expression of interleukin (IL) 4, IL-5, IL-8, IL-10, and interferon gamma. RESULTS: There was a higher number of neutrophils, macrophages, and cells expressing messenger RNA for interferon gamma and IL-8 in patients with CF than in patients with CS or in controls (P<.01). The number of eosinophils and cells expressing messenger RNA for IL-4, IL-5, and IL-10 was higher in patients with CS than in those with CF and controls (P<.01). CONCLUSIONS: Sinus disease in patients with CF presents different inflammatory-cell and cytokine profiles than that seen in other patients with CS. These results may explain the difference in response to treatment in the CF group.

Adult↗
PubMed2002

Acute bacterial sinusitis in adults: management in the primary care setting.

Sinus disease is inherently associated with viral upper respiratory tract infections and occurs in 90% of individuals with the common cold. Acute bacterial sinusitis occurs in 0.5 to 2% of these individuals. Although the diagnosis of acute bacterial sinusitis is usually based on physical findings, no one sign or symptom is either sensitive or specific for sinusitis. The predictive power can be significantly improved when all signs and symptoms are combined into a clinical impression. Imaging studies have not been shown to be cost effective in the initial assessment and treatment of patients in the primary care setting. Simple plain films may be indicated to resolve the diagnosis in patients with an equivocal history or to follow patients admitted to hospital with severe sinus disease. The initial management of acute sinusitis should be directed toward the relief of symptoms with a 7-day course of decongestants and mucoevacuents. For patients who fail to improve with symptomatic treatment, a 10-day course of amoxicillin is recommended. Second line antibiotics should be initiated if improvement is not seen within 72 to 96 hours.

Adult↗