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Biomedical subjects

Martin Holt

Publications and source records attributed to Martin Holt.

8 recordsLinked to original sources
PubMed2006

Living with HIV and negotiating psychological discourse.

Since the introduction of antiretroviral drug treatments, there has been increased interest in the psychological aspects of living with HIV and a growth of related research and therapeutic literature. While there has been concern about the 'remedicalization' of HIV, there is apparently less concern about its 'psychologization'. This article considers how the expansion of psychological discourse about HIV impacts on the lives of HIV-positive people in the era of contemporary treatments. Through analysis of group discussions with HIV-positive gay men, we examine how psychological strategies and terminology are adopted or reworked to cope with the uncertainties of living with HIV. We consider both the enabling and constraining effects of psychological modes of regulation, as they are taken up and reworked by HIV-positive people. Our analysis suggests a need for greater scrutiny of the ways in which psychological techniques are employed as solutions to the ambiguities of living with HIV.

Adaptation, Psychological↗
PubMed2005

A rule-based screening environmental risk assessment tool derived from EUSES.

Within the context and scope of the forthcoming European Union chemical regulations (REACH), there is a need to be able to prioritise the chemicals for evaluation. Therefore, a simple, pragmatic and adequately conservative approach for the identification of substances of very low or no immediate concern at an early stage is presented. The fundamental principles and basic concepts are derived from the EU Technical Guidance Document and EUSES, and are translated into an easy-to-use rule-based system. For this development, the effect on risk characterisation ratios (RCRs) of the key environmental parameters in EUSES was quantified (taking into account several standardised chemical release scenarios). Using statistical analysis, ranges were identified for each key parameter, within which the end result of the assessment was not significantly affected. This information was then translated into a lookup table from which environmental risk characterisation ratios can be directly read as a function of a few parameters.

Environmental Monitoring↗
PubMed2005

Students versus locals: young adults' constructions of the working-class other.

Following a review of the main approaches to the study of class in the social sciences, a critical/discursive approach is adopted to show how analysing an aspect of everyday life such as leisure and 'going out' can reveal the reproduction of dominant discourses about class. Forty-two middle-class young adults were taken on 'nights out' to bars and pubs and then interviewed later to generate group accounts of the people and places they encountered. An analysis of participants' talk about going out to bars and pubs is used to illustrate the ways in which class was constituted in their dialogue. Focusing on the distinction respondents made between students and locals we consider how working-class people are simultaneously rejected and desired and how a discourse of territoriality defines and reproduces class relations in commercial leisure spaces. We argue that social psychology has much to offer contemporary understandings of the ways in which social class is constituted and mobilized in everyday accounts of leisure and consumption, and discuss our analysis in the context of existing research. We end by considering the potential value of our distinctive method for the study of class relations in social psychology research.

Adult↗
PubMed2005

Mode of action and aquatic exposure thresholds of no concern.

Threshold concepts of toxicological concern are based on the possibility of establishing an exposure threshold value for chemicals below which no significant risk is to be expected. The objective of the present study is to address environmental thresholds of no toxicological concern for freshwater systems (ETNCaq) for organic chemicals. We analyzed environmental toxicological databases (acute and chronic endpoints) and substance hazard assessments. Lowest numbers and 95th-percentile values were derived using data stratification based on mode of action (MOA; 1 = inert chemicals; 2 = less inert chemicals; 3 = reactive chemicals; 4 = specifically acting chemicals). The ETNCaq values were derived by multiplying the lowest 95th percentile values with appropriate application factors; ETNCaq,MOA1-3 is approximately 0.1 microg/L. A preliminary analysis with complete MOA stratification of the databases shows that in the case of MOA1 or MOA2, the ETNCaq value could be even higher than 0.1 microg/L. A significantly lower ETNCaq,MOA4 value was observed based on the long-term toxicity information in the European Centre for the Ecotoxicology and Toxicology of Chemicals database. Application of the ETNCaq value in a tiered risk-assessment scheme may help chemical producers to set data-generation priorities and to refine or reduce animal use. It also may help to inform downstream users concerning the relative risk associated with their specific uses and be of value in putting environmental monitoring data into a risk-assessment perspective.

Animals↗
PubMed2004

A pilot randomized trial assessing the effects of autogenic training in early stage cancer patients in relation to psychological status and immune system responses.

Autogenic training (AT) is a type of meditation usually used for reducing stress. This pilot study describes how AT was used on a group of early stage cancer patients and the observed effect on stress-related behaviours and immune system responses. This was a randomized trial with 31 early stage breast cancer women, having received a lumpectomy and adjuvant radiotherapy. The women were randomized into two groups. Group 1 received a home visit only. Group 2 received a home visit and 2 months' weekly Autogenic training. At the beginning and end of the 2 monthly periods, the Hospital Anxiety and Depression Scale (HADS) and T and B cell markers were measured to give an indication of changes in immune system responses and measurement of anxiety and depression. At the end of the study, HADS scores and T and B cell markers remained similar in the women who did not receive AT. The women receiving AT showed a strong statistical difference for an improvement in their HADS scores and those women observed in a meditative state as opposed to a relaxed state were found to have an increase in their immune responses. This study suggests AT as a powerful self-help therapy.

Adaptation, Psychological↗
PubMed2003

Age and sex of drivers associated with child pedestrian injuries.

In 2002 there were 237 road traffic collisions (RTCs) involving a child pedestrian in Derbyshire. Complete details were available for 200 RTCs. There was a significantly lower proportion of female drivers (34.5%) than expected according to the number of female drivers registered nationally (43%). Similarly, there was a greater proportion of drivers under the age of 40 years involved in RTCs with children as pedestrians (58.5%) than anticipated (42.1%). Drivers between the ages of 17-20 and 31-40 years were significantly more likely to be involved in an RTC with a child as a pedestrian. Male drivers and drivers under the age of 40 years are more likely to be involved in RTCs with children as pedestrians. Educational publicity campaigns to reduce driver speeds in urban areas need to be targeted at those drivers most likely to be involved in an RTC with a child.

Accidents, Traffic↗
PubMed2002

Freshwater to saltwater toxicity extrapolation using species sensitivity distributions.

There is generally a lack of saltwater ecotoxicity data for risk assessment purposes, leaving an unknown margin of uncertainty in saltwater assessments that utilize surrogate freshwater data. Consequently, a need for sound scientific advice on the suitability of using freshwater data to extrapolate to saltwater effects exists. Here we use species sensitivity distributions to determine if freshwater datasets are adequately protective of saltwater species assemblages for 21 chemical substances. For ammonia and the metal compounds among these data, freshwater data were generally protective because freshwater organisms tended to be more sensitive. In contrast, for pesticide and narcotic compounds, saltwater species tended to be more sensitive and a suitable uncertainty factor would need to be applied to surrogate freshwater data. Biological and physicochemical factors contribute to such differences in freshwater and saltwater species sensitivities, but the species compositions of datasets used are also important.

Animals↗