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Mary K Colvin

Publications and source records attributed to Mary K Colvin.

4 recordsLinked to original sources
PubMed2005

Numerical processing in the two hemispheres: studies of a split-brain patient.

Neuroimaging and lesion studies have provided insights into the neural mechanisms underlying numerical processing, yet the roles of the right and left hemispheres have not been systematically investigated within a single study. To address this issue, we investigated subitizing and magnitude comparison abilities in a split-brain patient. The first experiment examined the two hemispheres' abilities to enumerate briefly presented sets of one to four stimuli. Both hemispheres were equally able to perform this task. The second and third experiments examined the hemispheres' abilities to make magnitude judgments about two simultaneously presented stimuli that were either identically coded (i.e., two Arabic numerals, two number words, or two arrays of dots) or differently coded (e.g., an Arabic numeral and a number word). Although the left hemisphere was more accurate than the right when the task involved number words, both hemispheres were able to make comparisons between numerical representations regardless of stimuli coding. In addition, both hemispheres exhibited a distance effect. The results are discussed in the context of Dehaene's triple-code model.

Adult↗
PubMed2005

Functional connectivity: integrating behavioral, diffusion tensor imaging, and functional magnetic resonance imaging data sets.

In the present study, we combined 2 types of magnetic resonance technology to explore individual differences on a task that required the recognition of objects presented from unusual viewpoints. This task was chosen based on previous work that has established the necessity of information transfer from the right parietal cortex to the left inferior cortex for its successful completion. We used reaction times (RTs) to localize regions of cortical activity in the superior parietal and inferior frontal regions (blood oxygen level-dependent [BOLD] response) that were more active with longer response times. These regions were then sampled, and their signal change used to predict individual differences in structural integrity of white matter in the corpus callosum (using diffusion tensor imaging). Results show that shorter RTs (and associated increases in BOLD response) are associated with increased organization in the splenium of the corpus callosum, whereas longer RTs are associated with increased organization in the genu.

Adult↗
PubMed2003

Phineas gauged: decision-making and the human prefrontal cortex.

Poor social judgment and decision-making abilities have often been attributed to people who have suffered injury to the ventromedial prefrontal cortex (VMPFC). However, few laboratory tests of decision-making have been conducted on these patients. The exception to this is the Iowa Gambling Task which has often, but not always, demonstrated differential performance between patients and controls. Results from patients with prefrontal cortex lesions on a novel test of decision-making are presented. Participants explored and chose from pairs of gambles that differed in their underlying distributions, primarily in the variance of their respective outcomes. In accordance with many findings from the behavioral decision-making literature, both young normal participants and older patient controls demonstrated a marked avoidance of risk and selected largely from secure, low variance gambles. In contrast, patients with ventromedial lesions were divided into two clear sub-groups. One group behaved similarly to normals, showing a risk-averse strategy. The other group displayed a distinctive risk-seeking behavior pattern, choosing predominantly from the high-variance, high-risk decks. This research demonstrates some of the advantages of using methods and theories from traditional decision-making research to study the behavior of patients, as well as the benefits of examining individual participants, and provides new insights into the nature of the decision-making deficit in patients with ventromedial prefrontal cortex lesions.

Adult↗