Masaki Nagase | PubMed Health

PubMed2006

[Equipment for electro-convulsive therapy].

ECT (electro-convulsive therapy) has been used for the treatment of depressive patients. First it was applied in patients only with sedatives without muscle relaxants, but now we employ muscle relaxants to avoid convulsion and its complications. It is called modified ECT (mECT). General anesthesia using muscle relaxant for ECT is now increasingly employed in Japan. Furthermore, there are some reports that ECT is effective not only in depressive patients but in chronic pain patients. This is why anesthesiologists are especially interested in ECT. In this chapter, clinical application, equipment and complications of ECT are discussed.

Chronic Disease↗

PubMed2003

[Patient safety management in surgery].

This article deals with practical guidelines for informed consent to surgery and strategies to avoid adverse events during the operative and postoperative periods. It also describes what to do in the event of accidents and what should or should not be done to avoid medical litigation.

Informed Consent↗

PubMed2002

Suppressive effect of spinal dorsal-horn neuronal activity by local spinal-cord cooling is reversed by naloxone in cats.

PURPOSE: The purpose of this study was to assess the effect of local spinal cord cooling on spinal dorsal-horn neuronal activity, with special emphasis on the role of endogenous opioid. METHODS: Decerebrate, spinal-cord-transected cats ( n= 30) were subjected to local spinal-cord irrigation, using 0.9 N saline solution (15 degrees C; n= 15, and 35 degrees C; n= 15) for 90 min. The extracellular, single-cell activity of spinal dorsal-horn neurons responding to noxious stimulation was recorded. Sixty-one minutes after induction of local spinal-cord irrigation, naloxone (0.1 mg.kg(-1)) was administered intravenously. Local spinal-cord blood flow was measured using the hydrogen clearance technique. RESULTS: Local spinal cord cooling produced significant suppression of both spontaneous and evoked activity (33.1 +/- 7.7% and 31.4 +/- 5.5%, respectively; mean +/- SE). Naloxone reversed this suppression immediately. Local spinal-cord blood flow was significantly reduced during spinal-cord cooling, but naloxone did not change local spinal-cord blood flow. CONCLUSION: The results demonstrate that endogenous opioids may play an important role in dorsal-horn neuronal suppression induced by local spinal-cord cooling.

Journal Article↗