Biomedical subjects

Masataka Deie

Publications and source records attributed to Masataka Deie.

23 records · Page 2Linked to original sources

PubMed2004

Effects of transforming growth factor-beta 1 on the early stages of healing of the Achilles tendon in a rat model.

We studied the effects of transforming growth factor-beta 1 (TGF-beta 1) on the genetic expression of procollagen type I and III and its effects on structural properties in the early stages of healing in rat Achilles tendon. The Achilles tendons in 90 rats were transsected and repaired immediately. TGF-beta 1 dissolved in phosphate-buffered saline was injected locally at the repair site using two different doses, and outcomes in both groups were compared to that in the control group given phosphate-buffered saline only. Five animals in each group were killed at one, two, and four weeks postoperatively, and the healing tendon was evaluated. A dose-dependent increase in the expression of procollagen type I and III mRNA was found one week postoperatively. The failure load and stiffness of the healing tendon were increased by TGF-beta 1 at two and four weeks.

Achilles Tendon↗

PubMed2003

Temporal changes in posterior laxity after isolated posterior cruciate ligament injury: 35 patients examined by stress radiography and MRI.

We examined the temporal changes in posterior laxity and MRI findings in acute isolated posterior cruciate ligament (PCL)-injured knees. 35 patients with acute isolated PCL injuries who attended our clinic within 10 weeks of an injury underwent nonoperative treatment, and were chronologically evaluated for posterior laxity and MRI. We divided them in 3 groups, as regards the evolution of laxity and MRI findings. In 20 patients, the degree of posterior laxity was slight throughout the observation periods. In 9 patients, who had severe posterior laxity on their initial visit, the laxity had improved markedly 6 months after injury and did not deteriorate. In 6 patients the severe posterior laxity did not improve during the study. 4 patients whose PCL on MRI was seen as a continuous swollen band having high signal intensity and showed consistently good stability or even an improvement. We conclude that acute isolated PCL injuries with a continuous swollen band on MRI should be treated conservatively for at least 6 months after injury, even if the posterior laxity is severe initially.

Adolescent↗

PubMed2002

Anterior knee laxity in young women varies with their menstrual cycle.

We studied 16 women 21-23 years old with regular menstrual cycles (28+/-4 days) and no history of knee injury. From their basal body temperatures and the serum concentrations of estradiol and progesterone, the follicular, ovulatory, and luteal phases were delineated. Using a KT-2000 arthrometer, anterior displacement at 89 N and 134 N and anterior terminal stiffness (N/mm) at 134 N were measured two or three times every week over a 4-week period. Eight men 21-23 years old were also measured. In women the anterior displacement at 89 N varied between the follicular and the ovulatory phase and between the follicular and the luteal phase ( P<0.05) and at 134 N between the follicular and the luteal phase ( P<0.05). There were no statistical differences in the anterior displacement with time in men, nor in anterior terminal stiffness in either sex. We conclude that anterior cruciate ligament laxity in women might be dependent on the concentrations of hormones.

Adult↗

PubMedDate not supplied

Relationship between osteochondritis dissecans of the lateral femoral condyle and lateral menisci types.

The purpose of this study was to examine the relationship between osteochondritis dissecans (OCD) of the lateral femoral condyle and lateral menisci. From 1993 to 2002, 38 knees (28 patients) were diagnosed with OCD of the lateral femoral condyle. OCD locations were graded by the Cahill and Berg classification. The types of lateral menisci were classified by Watanabe's classification. The relationship between OCD of the lateral femoral condyle and lateral menisci was examined. On the anterior-posterior view, 25 OCDs were located in zone 4 and 13 in zone 5. The types of lateral menisci were complete discoid in 19 knees, incomplete discoid in 15, and normal in 4. Ten of the 19 complete discoid menisci were damaged. Complete discoid menisci without tears were found in OCDs located in zone 4; incomplete discoid menisci were found in OCDs located in zone 5. The authors found a relationship between the type of OCD and the state of the lateral meniscus.

Adolescent↗

PubMedDate not supplied

Three-dimensional computed tomography imaging evidence of regeneration of the semitendinosus tendon harvested for anterior cruciate ligament reconstruction: a comparison with hamstring muscle strength.

OBJECTIVE: The purpose of this study was to evaluate the regeneration of semitendinosus tendons harvested for anterior cruciate ligament (ACL) reconstruction using 3-dimensional (3D) computed tomography (CT) imaging and to compare the degree of regeneration with hamstring strength. METHODS: Twenty-nine patients who underwent ACL reconstruction using ipsilateral autogenous semitendinosus tendons were examined before surgery and 6 and 12 months after surgery by 3D CT imaging. The types of regenerated tendons and the proximal shift of the muscle-tendon junction were evaluated. RESULTS: The types of regenerated semitendinosus tendons varied from case to case. There was a positive correlation between the peak torque ratio of the hamstring muscle strength and the proximal shift of the muscle-tendon junction 6 months after surgery. The proximal shift did not affect the peak torque ratio 12 months after surgery, however. CONCLUSIONS: A proximal shift of the muscle-tendon junction may help to explain the individual differences in early postoperative hamstring muscle strength recovery.

Adolescent↗